期刊
JOURNAL OF ENDOCRINOLOGY
卷 229, 期 3, 页码 R99-R115出版社
BIOSCIENTIFICA LTD
DOI: 10.1530/JOE-16-0021
关键词
PGC-1 alpha; type 2 diabetes mellitus; glucose metabolism; polymorphism
资金
- National Natural Science Foundation of China [81270804, 81370825, 81470966]
- Hebei Science and Technology Department Program [12966118D]
- Medical Research Program of the Hebei Provincial Health and Family Planning Commission [ZL20140063]
Type 2 diabetes mellitus (T2DM) is a chronic disease characterized by glucose metabolic disturbance. A number of transcription factors and coactivators are involved in this process. Peroxisome proliferator-activated receptor gamma coactivator 1 alpha (PGC-1 alpha) is an important transcription coactivator regulating cellular energy metabolism. Accumulating evidence has indicated that PGC-1 alpha is involved in the regulation of T2DM. Therefore, a better understanding of the roles of PGC-1 alpha may shed light on more efficient therapeutic strategies. Here, we review the most recent progress on PGC-1 alpha and discuss its regulatory network in major glucose metabolic tissues such as the liver, skeletal muscle, pancreas and kidney. The significant associations between PGC-1 alpha polymorphisms and T2DM are also discussed in this review.
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