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Liraglutide, a once-daily human GLP-1 analogue, added to a sulphonylurea over 26 weeks produces greater improvements in glycaemic and weight control compared with adding rosiglitazone or placebo in subjects with Type 2 diabetes (LEAD-1 SU)
M. Marre et al.
DIABETIC MEDICINE (2009)
Nutrient-dependent secretion of glucose-dependent insulinotropic polypeptide from primary murine K cells
H. E. Parker et al.
DIABETOLOGIA (2009)
Liraglutide vs insulin glargine and placebo in combination with metformin and sulfonylurea therapy in type 2 diabetes mellitus (LEAD-5 met+SU): a randomised controlled trial
D. Russell-Jones et al.
DIABETOLOGIA (2009)
Evidence for beneficial effects of compromised gastric inhibitory polypeptide action in obesity-related diabetes and possible therapeutic implications
N. Irwin et al.
DIABETOLOGIA (2009)
Surgical treatment of obesity
Marc Ward et al.
GASTROINTESTINAL ENDOSCOPY (2009)
Liraglutide versus glimepiride monotherapy for type 2 diabetes (LEAD-3 Mono): a randomised, 52-week, phase III, double-blind, parallel-treatment trial
Alan Garber et al.
LANCET (2009)
Liraglutide once a day versus exenatide twice a day for type 2 diabetes: a 26-week randomised, parallel-group, multinational, open-label trial (LEAD-6)
John B. Buse et al.
LANCET (2009)
A new glucagon and GLP-1 co-agonist eliminates obesity in rodents
Jonathan W. Day et al.
NATURE CHEMICAL BIOLOGY (2009)
Enhanced Weight Loss With Pramlintide/Metreleptin: An Integrated Neurohormonal Approach to Obesity Pharmacotherapy
Eric Ravussin et al.
OBESITY (2009)
Laparoscopic Sleeve Gastrectomy with Duodenojejunal Bypass: Technique and Preliminary Results
Kazunori Kasama et al.
OBESITY SURGERY (2009)
Human gut microbiota in obesity and after gastric bypass
Husen Zhang et al.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2009)
Bile-acid-activated receptors: targeting TGR5 and farnesoid-X-receptor in lipid and glucose disorders
Stefano Fiorucci et al.
TRENDS IN PHARMACOLOGICAL SCIENCES (2009)
Stimulation of both type I and type II corticosteroid receptors blunts counterregulatory responses to subsequent hypoglycemia in healthy man
Stephanie M. Gustavson et al.
AMERICAN JOURNAL OF PHYSIOLOGY-ENDOCRINOLOGY AND METABOLISM (2008)
Circulating peptide YY, weight loss, and glucose homeostasis after gastric bypass surgery in morbidly obese subjects
Rosa Morinigo et al.
ANNALS OF SURGERY (2008)
Ileal transposition controls diabetes as well as modified duodenal jejunal bypass with better lipid lowering in a nonobese rat model of type II diabetes by increasing GLP-1
Tian Tian Wang et al.
ANNALS OF SURGERY (2008)
Glucose Sensing in L Cells: A Primary Cell Study
Frank Reimann et al.
CELL METABOLISM (2008)
Gpr40 is expressed in enteroendocrine cells and mediates free fatty acid stimulation of incretin secretion
Sara Edfalk et al.
DIABETES (2008)
Exenatide once weekly versus twice daily for the treatment of type 2 diabetes: a randomised, open-label, non-inferiority study
Daniel J. Drucker et al.
LANCET (2008)
Upper intestinal lipids trigger a gut-brain-liver axis to regulate glucose production
Penny Y. T. Wang et al.
NATURE (2008)
Targeting bile-acid signalling for metabolic diseases
Charles Thomas et al.
NATURE REVIEWS DRUG DISCOVERY (2008)
Effects of gastric bypass and gastric banding on glucose kinetics and gut hormone release
Frederique Rodieux et al.
OBESITY (2008)
Gut hormones as mediators of appetite and weight loss after Roux-en-Y gastric bypass
Carel W. le Roux et al.
ANNALS OF SURGERY (2007)
Glucagon-like peptide-1 (GLP-1) receptors expressed on nerve terminals in the portal vein mediate the effects of endogenous GLP-1 on glucose tolerance in rats
Torsten P. Vahl et al.
ENDOCRINOLOGY (2007)
Gut-expressed gustducin and taste receptors regulate secretion of glucagon-like peptide-1
Hyeung-Jin Jang et al.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2007)
Ten-year trends in health-related quality of life after surgical and conventional treatment for severe obesity:: the SOS intervention study
J. Karlsson et al.
INTERNATIONAL JOURNAL OF OBESITY (2007)
Protein kinase Cζ is required for oleic acid-induced secretion of glucagon-like peptide-1 by intestinal endocrine L cells
Roman Iakoubov et al.
ENDOCRINOLOGY (2007)
Design of a long acting peptide functioning as both a glucagon-like peptide-1 receptor agonist and a glucagon receptor antagonist
CQ Pan et al.
JOURNAL OF BIOLOGICAL CHEMISTRY (2006)
Oligofructose promotes satiety in healthy human: a pilot study
PD Cani et al.
EUROPEAN JOURNAL OF CLINICAL NUTRITION (2006)
Farnesoid X receptor is essential for normal glucose homeostasis
K Ma et al.
JOURNAL OF CLINICAL INVESTIGATION (2006)
Human duodenal enteroendocrine cells: source of both incretin peptides, GLP-1 and GIP
MJ Theodorakis et al.
AMERICAN JOURNAL OF PHYSIOLOGY-ENDOCRINOLOGY AND METABOLISM (2006)
Deorphanization of a G protein-coupled receptor for oleoylethanolamide and its use in the discovery of small-molecule hypophagic agents
HA Overton et al.
CELL METABOLISM (2006)
The release of GLP-1 and ghrelin, but not GIP and CCK, by glucose is dependent upon the length of small intestine exposed
Tanya J. Little et al.
AMERICAN JOURNAL OF PHYSIOLOGY-ENDOCRINOLOGY AND METABOLISM (2006)
Gut hormone profiles following bariatric surgery favor an anorectic state, facilitate weight loss, and improve metabolic parameters
CW le Roux et al.
ANNALS OF SURGERY (2006)
The kinase LKB1 mediates glucose homeostasis in liver and therapeutic effects of metformin
RJ Shaw et al.
SCIENCE (2005)
Brain glucagon-like peptide-1 increases insulin secretion and muscle insulin resistance to favor hepatic glycogen storage
C Knauf et al.
JOURNAL OF CLINICAL INVESTIGATION (2005)
Exenatide versus insulin glargine in patients with suboptimally controlled type 2 diabetes - A randomized trial
RJ Heine et al.
ANNALS OF INTERNAL MEDICINE (2005)
Proglucagon-derived peptides: Mechanisms of action and therapeutic potential
EM Sinclair et al.
PHYSIOLOGY (2005)
Oligofructose promotes satiety in rats fed a high-fat diet: Involvement of glucagon-like peptide-1
PD Cani et al.
OBESITY RESEARCH (2005)
Effects of exenatide (exendin-4) on glycemic control over 30 weeks in patients with type 2 diabetes treated with metformin and a sulfonylurea
DM Kendall et al.
DIABETES CARE (2005)
Effects of exenatide (exendin-4) on glycemic control and weight over 30 weeks in metformin-treated patients with type 2 diabetes
RA DeFronzo et al.
DIABETES CARE (2005)
Bile acids promote glucagon-like peptide-1 secretion through TGR5 in a murine enteroendocrine cell line STC-1
S Katsuma et al.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS (2005)
Free fatty acids regulate gut incretin glucagon-like peptide-1 secretion through GPR120
A Hirasawa et al.
NATURE MEDICINE (2005)
Double incretin receptor knockout (DIRKO) mice reveal an essential role for the enteroinsular axis in transducing the glucoregulatory actions of DPP-IV inhibitors
T Hansotia et al.
DIABETES (2004)
Effect of fat replacement by inulin or lupin-kernel fibre on sausage patty acceptability, post-meal perceptions of satiety and food intake in ment
BJ Archer et al.
BRITISH JOURNAL OF NUTRITION (2004)
Akkermansia muciniphila gen. nov., sp nov., a human intestinal mucin-degrading bacterium
M Derrien et al.
INTERNATIONAL JOURNAL OF SYSTEMATIC AND EVOLUTIONARY MICROBIOLOGY (2004)
Inulin-type fructans modulate gastrointestinal peptides involved in appetite regulation (glucagon-like peptide-1 and ghrelin) in rats
PD Cani et al.
BRITISH JOURNAL OF NUTRITION (2004)
The early effect of the Roux-en-Y gastric bypass on hormones involved in body weight regulation and glucose metabolism
F Rubino et al.
ANNALS OF SURGERY (2004)
Effects of exenatide (exendin-4) on glycemic control over 30 weeks in sulfonylurea-treated patients with type 2 diabetes
JB Buse et al.
DIABETES CARE (2004)
Bariatric surgery: A systematic review and meta-analysis
H Buchwald et al.
JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION (2004)
A novel glucose-sensing mechanism contributing to glucagon-like peptide-1 secretion from the GLUTag cell line
FM Gribble et al.
DIABETES (2003)
The orphan G protein-coupled receptor GPR40 is activated by medium and long chain fatty acids
CP Briscoe et al.
JOURNAL OF BIOLOGICAL CHEMISTRY (2003)
Entry of exendin-4 into brain is rapid but may be limited at high doses
AJ Kastin et al.
INTERNATIONAL JOURNAL OF OBESITY (2003)
Pharmacokinetic-pharmacodynamic analysis of the glucose-lowering effect of metformin in diabetic rats reveals first-pass pharmacodynamic effect
D Stepensky et al.
DRUG METABOLISM AND DISPOSITION (2002)
Glucose competence of the hepatoportal vein sensor requires the presence of an activated glucagon-like peptide-1 receptor
R Burcelin et al.
DIABETES (2001)
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