Alphaherpesvirus glycoprotein E: A review of its interactions with other proteins of the virus and its application in vaccinology

The viral envelope glycoprotein E (gE) is required for cell-to-cell transmission, anterograde and retrograde neurotransmission, and immune evasion of alphaherpesviruses. gE can also interact with other proteins of the virus and perform various functions in the virus life cycle. In addition, the gE gene is often the target gene for the construction of gene-deleted attenuated marker vaccines. In recent years, new progress has been made in the research and vaccine application of gE with other proteins of the virus. This article reviews the structure of gE, the relationship between gE and other proteins of the virus, and the application of gE in vaccinology, which provides useful information for further research on gE.

Automated summary

The viral envelope glycoprotein E (gE) plays crucial roles in the cell-to-cell transmission, neurotransmission, and immune evasion of alphaherpesviruses. It interacts with other viral proteins and performs various functions in the virus life cycle. Moreover, the gE gene is commonly used as a target for constructing gene-deleted attenuated marker vaccines. Recent advancements have been made in the research and application of gE in conjunction with other viral proteins, which provide valuable insights for further studies on gE.