4.6 Review

Mini Review Therapeutic Strategies Targeting for Biofilm and Bone Infections

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Review Biochemistry & Molecular Biology

Small Drugs, Huge Impact: The Extraordinary Impact of Antisense Oligonucleotides in Research and Drug Development

Anais M. Quemener et al.

Summary: Antisense oligonucleotides (ASOs) are a versatile class of drugs that can precisely target RNA and alter nucleic acid function. In the context of the COVID-19 pandemic, ASOs may serve as a powerful tool to target the virus RNA and provide therapeutic strategies. However, no ASO has gained FDA approval yet.

MOLECULES (2022)

Review Pharmacology & Pharmacy

Bioactive coatings with anti-osteoclast therapeutic agents for bone implants: Enhanced compliance and prolonged implant life

Dragana Bjelic et al.

Summary: The use of therapeutic agents that inhibit bone resorption is important for the longevity of implants, revision surgeries, and the healthcare system. This review focuses on incorporating osteoclast inhibitors into bioactive coatings for bone implants and discusses the challenges of systemic treatment. It also explores the suitable concentrations, release times, and effects of the antiresorptive agents on nearby cells or bone tissue. However, further research is needed to optimize implant design and personalize the coating material and antiresorptive agent selection.

PHARMACOLOGICAL RESEARCH (2022)

Article Surgery

Bioinformatic Analysis Reveals Hub Immune-Related Genes of Diabetic Foot Ulcers

Yanchao Rong et al.

Summary: Diabetic foot ulcer (DFU) is a complex and devastating complication of diabetes mellitus. Compared to oral wound healing, DFU shows enrichment in cellular metabolism-related pathways but lacks activation of inflammatory and immune-related pathways. The study identifies potential immune-related biomarkers and provides new insights into the molecular basis of this debilitating disease.

FRONTIERS IN SURGERY (2022)

Review Infectious Diseases

Diagnosis of vertebral osteomyelitis

Julian Maamari et al.

Summary: Native vertebral osteomyelitis is a potentially fatal infection with an increasing incidence. Prompt diagnosis and appropriate treatment are important to prevent complications. Various laboratory and imaging tools can be used to establish an accurate diagnosis.

JOURNAL OF BONE AND JOINT INFECTION (2022)

Review Pharmacology & Pharmacy

Bisphosphonates for delivering drugs to bone

Shuting Sun et al.

Summary: Advancements in designing bone-selective drugs have opened up new possibilities for treating various bone-related diseases. These drugs show promising potential in improving efficacy and safety, especially in addressing bone-related cancers, infections, and osteomyelitis.

BRITISH JOURNAL OF PHARMACOLOGY (2021)

Article Environmental Sciences

Quantitative acetylome analysis reveals involvement of glucosyltransferase acetylation in Streptococcus mutans biofilm formation

Lei Lei et al.

Summary: The study identified the acetylome of S. mutans and compared the quantitative acetylome analysis between bacterial biofilm growth and planktonic growth. The dynamic changes of protein acetylation were quantified using TMT labeling and Kac affinity enrichment. The results showed that the acetylation of lysine in proteins varies during biofilm development, revealing a potential regulatory mechanism for glucosyltransferases function.

ENVIRONMENTAL MICROBIOLOGY REPORTS (2021)

Review Orthopedics

Bacteriophage therapy for bone and joint infections AN INSTRUCTIONAL REVIEW

B. P. Gibb et al.

Summary: Antibiotic resistance poses a serious threat to human health, while phage therapy may provide an effective solution to antibiotic-resistant infections. Research in this area is beginning to show successful results, primarily in non-orthopaedic fields.

BONE & JOINT JOURNAL (2021)

Review Microbiology

Bacteria and Host Interplay in Staphylococcus aureus Septic Arthritis and Sepsis

Tao Jin et al.

Summary: Staphylococcus aureus infections pose a significant healthcare challenge, necessitating the development of new treatment options. Understanding the interaction between bacterial virulence factors and host immune response is crucial for determining disease outcomes. The timing and approach of treatment play a critical role in the effectiveness of therapies.

PATHOGENS (2021)

Review Biochemical Research Methods

Unlocking the next generation of phage therapy: the key is in the receptors

Fernando L. Gordillo Altamirano et al.

Summary: Understanding the function and location of phage receptors is crucial for improving and innovating the use of phage therapy. This can lead to the design of intelligent phage cocktails, discovery of new phage-derived antimicrobials, and guiding the evolution of phage resistance towards clinically exploitable phenotypes.

CURRENT OPINION IN BIOTECHNOLOGY (2021)

Review Pharmacology & Pharmacy

Antimicrobial Peptides in the Battle against Orthopedic Implant-Related Infections: A Review

Bruna Costa et al.

Summary: The prevention of orthopedic implant-related infections is a major medical challenge, and antimicrobial peptides (AMPs) are considered promising alternatives to conventional antibiotics due to their broad-spectrum activity and low propensity for resistance. Research strategies involving AMP-releasing and immobilization onto surfaces show potential for preventing infections, with a focus needed on clinical validation and translation efforts.

PHARMACEUTICS (2021)

Review Pharmacology & Pharmacy

The Development of Third-Generation Tetracycline Antibiotics and New Perspectives

Aura Rusu et al.

Summary: The tetracycline antibiotic class has introduced new valuable members such as tigecycline, omadacycline, eravacycline, and sarecycline, which have excellent development potential. These modern tetracyclines have a broad antibacterial spectrum and are effective in treating conditions like acne. The class continues to be of interest to researchers for both antibiotic and other biological effects, with new derivatives being developed.

PHARMACEUTICS (2021)

Article Biotechnology & Applied Microbiology

A Bone-Targeting Enoxacin Delivery System to Eradicate Staphylococcus Aureus-Related Implantation Infections and Bone Loss

Cong Yao et al.

Summary: A novel nanosystem based on enoxacin-loaded mesoporous silica nanoparticles was developed, showing targeted release of enoxacin in infected bone tissue and exhibiting antibacterial and anti-osteoclast properties.

FRONTIERS IN BIOENGINEERING AND BIOTECHNOLOGY (2021)

Article Microbiology

Bacteriophage Therapy for the Prevention and Treatment of Fracture-Related Infection Caused by Staphylococcus aureus: a Preclinical Study

Jolien Onsea et al.

Summary: Although phage therapy has shown promising results in preventing orthopedic device-related infections, its efficacy in treatment remains unclear, with the risk of neutralizing antibodies development. Encapsulation of phages in a hydrogel may reduce the development of neutralizing antibodies, but further research and improvements in application methods are necessary.

MICROBIOLOGY SPECTRUM (2021)

Article Infectious Diseases

The Role of Staphylococcus aureus YycFG in Gene Regulation, Biofilm Organization and Drug Resistance

Shizhou Wu et al.

Summary: Antibiotic resistance, particularly in MRSA infections, is a serious global health concern with significant social and financial consequences. The YycFG two-component signal transduction system in Staphylococcus aureus is crucial for bacterial viability and plays a key role in cell membrane metabolism, cell wall synthesis, and biofilm formation. Inhibition of the YycFG pathway shows promise as a potential target for managing MRSA-induced infections by reducing biofilm formation and bacterial pathogenicity.

ANTIBIOTICS-BASEL (2021)

Review Orthopedics

A systematic review of phage therapy applied to bone and joint infections: an analysis of success rate treatment modalities and safety

Joseph Geneviere et al.

Summary: This systematic review examined the success rate, current treatment modalities, and safety of phage therapy in bone and joint infections. The results showed potential benefits of phage therapy in treating such infections, but further clinical trials are needed to evaluate its efficacy and determine optimal treatment modalities.

EFORT OPEN REVIEWS (2021)

Review Nanoscience & Nanotechnology

Nanomaterials-Upconverted Hydroxyapatite for Bone Tissue Engineering and a Platform for Drug Delivery

Nur Akma Abdul Halim et al.

Summary: Hydroxyapatite and its nanocomposites have potential applications in bone tissue engineering and drug loading systems, with research focused on enhancing their mechanical properties for broader usage.

INTERNATIONAL JOURNAL OF NANOMEDICINE (2021)

Review Biochemistry & Molecular Biology

Impact of the Host-Microbiome on Osteomyelitis Pathogenesis

Jun Chen et al.

Summary: The microbiome, a collection of microbial genomes in a specific environment, has a significant impact on host bone health. Disruption in the host-microbiome interaction can lead to conditions like osteomyelitis and other bone diseases, indicating the importance of understanding the role of microbiota in bone health.

FRONTIERS IN MOLECULAR BIOSCIENCES (2021)

Article Materials Science, Biomaterials

An injectable and antibacterial calcium phosphate scaffold inhibiting Staphylococcus aureus and supporting stem cells for bone regeneration

Shizhou Wu et al.

Summary: The study developed an antibacterial CPC-chitosan-penicillin-alginate microbead scaffold with strong antibacterial effects on S. aureus. This scaffold demonstrated good biocompatibility, supported stem cell viability, and had injectability and good strength for osteogenesis.

MATERIALS SCIENCE & ENGINEERING C-MATERIALS FOR BIOLOGICAL APPLICATIONS (2021)

Article Engineering, Biomedical

Poly(methyl methacrylate) Bone Cement Composite Can Be Refilled with Antibiotics after Implantation in Femur or Soft Tissue

Erika L. Cyphert et al.

Summary: This study investigates the development of bone and muscle refilling models for antibiotic delivery, demonstrating that incorporating insoluble cyclodextrin microparticles into PMMA can improve antibiotic release and allow for post-implantation drug refilling. The results show sustained and on-demand antimicrobial activity without implant removal, proving the technique to be viable for treating infections with prolonged effects.

JOURNAL OF FUNCTIONAL BIOMATERIALS (2021)

Article Engineering, Biomedical

Bacteriophage delivering hydrogels reduce biofilm formation in vitro and infection in vivo

James A. Wroe et al.

JOURNAL OF BIOMEDICAL MATERIALS RESEARCH PART A (2020)

Review Pharmacology & Pharmacy

Recent advances in bone-targeted therapy

Chen Shi et al.

PHARMACOLOGY & THERAPEUTICS (2020)

Article Microbiology

Safety of bacteriophage therapy in severe Staphylococcus aureus infection

Aleksandra Petrovic Fabijan et al.

NATURE MICROBIOLOGY (2020)

Review Biotechnology & Applied Microbiology

Nanoscale Drug Delivery Systems: From Medicine to Agriculture

Pablo Vega-Vasquez et al.

FRONTIERS IN BIOENGINEERING AND BIOTECHNOLOGY (2020)

Review Biochemistry & Molecular Biology

A New Era of Antibiotics: The Clinical Potential of Antimicrobial Peptides

Katrina Browne et al.

INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES (2020)

Review Infectious Diseases

Acute Hematogenous Osteomyelitis in Children: Clinical Presentation and Management

J. Chase McNeil

INFECTION AND DRUG RESISTANCE (2020)

Review Orthopedics

New perspectives on traumatic bone infections

Ruo-Hui Tang et al.

CHINESE JOURNAL OF TRAUMATOLOGY (2020)

Article Nanoscience & Nanotechnology

Sesamol-Loaded PLGA Nanosuspension for Accelerating Wound Healing in Diabetic Foot Ulcer in Rats

Karthik Gourishetti et al.

INTERNATIONAL JOURNAL OF NANOMEDICINE (2020)

Article Cell & Tissue Engineering

BACTERIOPHAGE THERAPY AS A TREATMENT STRATEGY FOR ORTHOPAEDIC-DEVICE-RELATED INFECTIONS: WHERE DO WE STAND?

J. Onsea et al.

EUROPEAN CELLS & MATERIALS (2020)

Article Biochemistry & Molecular Biology

In vitro evaluation of sustained ciprofloxacin release from κ-carrageenan-crosslinked chitosan/hydroxyapatite hydrogel nanocomposites

Gholam Reza Mandavinia et al.

INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES (2019)

Article Microbiology

Respiration and Small Colony Variants of Staphylococcus aureus

Richard Proctor

MICROBIOLOGY SPECTRUM (2019)

Article Genetics & Heredity

Mechanisms of DNA Uptake by Naturally Competent Bacteria

David Dubnau et al.

Annual Review of Genetics (2019)

Article Dentistry, Oral Surgery & Medicine

Microbiological Aspects of Traumatic Injuries

Ashraf F. Fouad

JOURNAL OF ENDODONTICS (2019)

Review Microbiology

Mechanisms of Action for Antimicrobial Peptides With Antibacterial and Antibiofilm Functions

Nigare Raheem et al.

FRONTIERS IN MICROBIOLOGY (2019)

Review Microbiology

Staphylococcal Osteomyelitis: Disease Progression, Treatment Challenges, and Future Directions

Nicola Kavanagh et al.

CLINICAL MICROBIOLOGY REVIEWS (2018)

Article Dentistry, Oral Surgery & Medicine

Activity of Streptococcus mutans VicR Is Modulated by Antisense RNA

L. Lei et al.

JOURNAL OF DENTAL RESEARCH (2018)

Article Multidisciplinary Sciences

Transformation of amorphous calcium phosphate to bone-like apatite

Antiope Lotsari et al.

NATURE COMMUNICATIONS (2018)

Article Immunology

Osteomyelitis

Steven K. Schmitt

INFECTIOUS DISEASE CLINICS OF NORTH AMERICA (2017)

Review Infectious Diseases

Bone responses in health and infectious diseases: A focus on osteoblasts

Cecile Saint-Pastou Terrier et al.

JOURNAL OF INFECTION (2017)

Article Dentistry, Oral Surgery & Medicine

Doxycycline induces bone repair and changes in Wnt signalling

Katia do Nascimento Gomes et al.

INTERNATIONAL JOURNAL OF ORAL SCIENCE (2017)

Review Immunology

Orthopaedic biofilm infections

Werner Zimmerli et al.

Article Chemistry, Multidisciplinary

Osteoblast-Targeting-Peptide Modified Nanoparticle for siRNA/microRNA Delivery

Yao Sun et al.

ACS NANO (2016)

Editorial Material Biochemistry & Molecular Biology

Antimicrobial peptides

Ling-juan Zhang et al.

CURRENT BIOLOGY (2016)

Article Immunology

Phage therapy of staphylococcal chronic osteomyelitis in experimental animal model

Chandan Kishor et al.

INDIAN JOURNAL OF MEDICAL RESEARCH (2016)

Article Microbiology

Antibiofilm Peptides: Potential as Broad-Spectrum Agents

Daniel Pletzer et al.

JOURNAL OF BACTERIOLOGY (2016)

Review Endocrinology & Metabolism

The Mineral-Collagen Interface in Bone

S. R. Stock

CALCIFIED TISSUE INTERNATIONAL (2015)

Review Pharmacology & Pharmacy

Bisphosphonate-modified biomaterials for drug delivery and bone tissue engineering

Dmitri A. Ossipov

EXPERT OPINION ON DRUG DELIVERY (2015)

Article Endocrinology & Metabolism

Anabolic Bone Formation Via a Site-Specific Bone-Targeting Delivery System by Interfering With Semaphorin 4d Expression

Yufeng Zhang et al.

JOURNAL OF BONE AND MINERAL RESEARCH (2015)

Review Immunology

Staphylococcus aureus vs. Osteoblast: Relationship and Consequences in Osteomyelitis

Jerome Josse et al.

FRONTIERS IN CELLULAR AND INFECTION MICROBIOLOGY (2015)

Article Immunology

Dual Impact of Live Staphylococcus aureus on the Osteoclast Lineage, Leading to Increased Bone Resorption

Sophie Trouillet-Assant et al.

JOURNAL OF INFECTIOUS DISEASES (2015)

Article Rheumatology

Antibiotic-Killed Staphylococcus aureus Induces Destructive Arthritis in Mice

Abukar Ali et al.

ARTHRITIS & RHEUMATOLOGY (2015)

Article Nanoscience & Nanotechnology

Novel Theranostic DNA Nanoscaffolds for the Simultaneous Detection and Killing of Escherichia coli and Staphylococcus aureus

Magdiel I. Setyawati et al.

ACS APPLIED MATERIALS & INTERFACES (2014)

Article Microbiology

A Broad-Spectrum Antibiofilm Peptide Enhances Antibiotic Action against Bacterial Biofilms

Fany Reffuveille et al.

ANTIMICROBIAL AGENTS AND CHEMOTHERAPY (2014)

Review Infectious Diseases

Oral antibiotic treatment of staphylococcal bone and joint infections in adults

Baek-Nam Kim et al.

JOURNAL OF ANTIMICROBIAL CHEMOTHERAPY (2014)

Article Dentistry, Oral Surgery & Medicine

Bisphosphonate Uptake in Areas of Tooth Extraction or Periapical Disease

Simon Cheong et al.

JOURNAL OF ORAL AND MAXILLOFACIAL SURGERY (2014)

Article Microbiology

Broad-Spectrum Anti-biofilm Peptide That Targets a Cellular Stress Response

Cesar de la Fuente-Nunez et al.

PLOS PATHOGENS (2014)

Review Microbiology

The factors affecting effectiveness of treatment in phages therapy

Mai Huong Ly-Chatain

FRONTIERS IN MICROBIOLOGY (2014)

Article Multidisciplinary Sciences

Synergy as a rationale for phage therapy using phage cocktails

Matthew Schmerer et al.

Review Microbiology

Wall Teichoic Acids of Gram-Positive Bacteria

Stephanie Brown et al.

ANNUAL REVIEW OF MICROBIOLOGY, VOL 67 (2013)

Article Biotechnology & Applied Microbiology

Aggregatibacter actinomycetemcomitans biofilm killing by a targeted ciprofloxacin prodrug

Benjamin D. Reeves et al.

BIOFOULING (2013)

Review Microbiology

Phage cocktails and the future of phage therapy

Benjamin K. Chan et al.

FUTURE MICROBIOLOGY (2013)

Article Medicine, Research & Experimental

Staphylococcus aureus supernatant induces the release of mouse β-defensin-14 from osteoblasts via the p38 MAPK and NF-κB pathways

Chen Zhu et al.

INTERNATIONAL JOURNAL OF MOLECULAR MEDICINE (2013)

Article Orthopedics

Bacteriophage Therapy in Implant-Related Infections An Experimental Study

Cengiz Yilmaz et al.

JOURNAL OF BONE AND JOINT SURGERY-AMERICAN VOLUME (2013)

Review Pharmacology & Pharmacy

The potential role of newer gram-positive antibiotics in the setting of osteomyelitis of adults

Ryan P. Moenster et al.

JOURNAL OF CLINICAL PHARMACY AND THERAPEUTICS (2013)

Article Immunology

Quantitation and Composition of Cutaneous Microbiota in Diabetic and Nondiabetic Men

Henry Redel et al.

JOURNAL OF INFECTIOUS DISEASES (2013)

Article Biochemistry & Molecular Biology

Enoxacin Directly Inhibits Osteoclastogenesis without Inducing Apoptosis

Edgardo J. Toro et al.

JOURNAL OF BIOLOGICAL CHEMISTRY (2012)

Article Engineering, Biomedical

New antibacterial microporous CaP materials loaded with phages for prophylactic treatment in bone surgery

Edwige Meurice et al.

JOURNAL OF MATERIALS SCIENCE-MATERIALS IN MEDICINE (2012)

Article Biochemistry & Molecular Biology

A delivery system targeting bone formation surfaces to facilitate RNAi-based anabolic therapy

Ge Zhang et al.

NATURE MEDICINE (2012)

Article Pharmacology & Pharmacy

Local Antimicrobial Administration for Prophylaxis of Surgical Site Infections

Paul Huiras et al.

PHARMACOTHERAPY (2012)

Article Cell Biology

A Tissue Engineering Solution for Segmental Defect Regeneration in Load-Bearing Long Bones

Johannes C. Reichert et al.

SCIENCE TRANSLATIONAL MEDICINE (2012)

Review Engineering, Biomedical

Covalent immobilization of antimicrobial peptides (AMPs) onto biomaterial surfaces

Fabiola Costa et al.

ACTA BIOMATERIALIA (2011)

Review Endocrinology & Metabolism

Denosumab and bisphosphonates: Different mechanisms of action and effects

Roland Baron et al.

Review Endocrinology & Metabolism

Do RANKL inhibitors (denosumab) affect inflammation and immunity?

S. Ferrari-Lacraz et al.

OSTEOPOROSIS INTERNATIONAL (2011)

Article Orthopedics

The effect of Staphylococcus aureus on apoptosis of cultured human osteoblasts

Ren-de Ning et al.

Orthopaedic Surgery (2011)

Review Immunology

Cathelicidin LL-37: A Multitask Antimicrobial Peptide

Robert Bucki et al.

ARCHIVUM IMMUNOLOGIAE ET THERAPIAE EXPERIMENTALIS (2010)

Review Microbiology

Interaction of staphylococci with bone

John A. Wright et al.

INTERNATIONAL JOURNAL OF MEDICAL MICROBIOLOGY (2010)

Article Chemistry, Physical

Studies on the sorption of tetracycline onto clays and marine sediment from seawater

Jiangtao Wang et al.

JOURNAL OF COLLOID AND INTERFACE SCIENCE (2010)

Review Multidisciplinary Sciences

A three-dimensional view of the molecular machinery of RNA interference

Martin Jinek et al.

NATURE (2009)

Article Surgery

Osteomyelitis of the Long Bones

Jason Calhoun et al.

Seminars in Plastic Surgery (2009)

Article Immunology

Human host defense peptide LL-37 prevents bacterial biofilm formation

Joerg Overhage et al.

INFECTION AND IMMUNITY (2008)

Article Biochemical Research Methods

Osteotropic peptide that differentiates functional domains of the skeleton

Dong Wang et al.

BIOCONJUGATE CHEMISTRY (2007)

Article Microbiology

Experimental phage therapy against Staphylococcus aureus in mice

Rosanna Capparelli et al.

ANTIMICROBIAL AGENTS AND CHEMOTHERAPY (2007)

Article Dentistry, Oral Surgery & Medicine

RANKL inhibition through osteoprotegerin blocks bone loss in experimental periodontitis

Qiming Jin et al.

JOURNAL OF PERIODONTOLOGY (2007)

Article Biochemical Research Methods

Preparation of LL-37-grafted titanium surfaces with bactericidal activity

M Gabriel et al.

BIOCONJUGATE CHEMISTRY (2006)

Review Pharmacology & Pharmacy

Bone-targeting macromolecular therapeutics

D Wang et al.

ADVANCED DRUG DELIVERY REVIEWS (2005)

Review Microbiology

Bacterial biofilms: From the natural environment to infectious diseases

L Hall-Stoodley et al.

NATURE REVIEWS MICROBIOLOGY (2004)

Review Medicine, General & Internal

Osteomyelitis

DP Lew et al.

LANCET (2004)

Article Multidisciplinary Sciences

The RNAi revolution

CD Novina et al.

NATURE (2004)

Review Dermatology

Tetracycline and other tetracycline-derivative staining of the teeth and oral cavity

AR Sánchez et al.

INTERNATIONAL JOURNAL OF DERMATOLOGY (2004)

Article Biochemistry & Molecular Biology

Tumor necrosis factor-alpha mediates RANK ligand stimulation of osteoclast differentiation by an autocrine mechanism

W Zou et al.

JOURNAL OF CELLULAR BIOCHEMISTRY (2001)

Article Microbiology

Intracellular Staphylococcus aureus induces apoptosis in mouse osteoblasts

KA Tucker et al.

FEMS MICROBIOLOGY LETTERS (2000)