期刊
FRONTIERS IN MICROBIOLOGY
卷 13, 期 -, 页码 -出版社
FRONTIERS MEDIA SA
DOI: 10.3389/fmicb.2022.905380
关键词
preterm; gut; microbiota; NEC; infant
类别
资金
- National Key R&D Program of China [2021YFC2701700]
- National Natural Science Foundation of China [82100590, 81971433, 81971428]
- Science and Technology Bureau of Sichuan Province [2021YJ0017, 2020YFS0041]
This study discusses the impact of the increasing global preterm birth rate on maternal and infant health, with a particular focus on the detrimental effects of disordered gut microbiota on the growth, development, and health of preterm infants. The potential association between clinical phenotypes and gut microbiota is explored, and future research directions are suggested.
Preterm birth remains a major maternal and infant health issue worldwide particularly with an increase in the global preterm birth rate, which requires more interventions to manage the consequences of preterm birth. In addition to traditional complications, recent studies have shown that the succession of gut microbiota of preterm infants is disordered due to the systemic physiological immaturity, which confers negative influences on the growth, development, and health of infants. In the present study, we briefly discussed the prevalence of preterm birth worldwide and then highlighted the signatures of gut microbiota in preterm infants within the first 1000 days of life after the birth categorized into birth, infancy, and childhood. Afterward, we focused on the potential association of clinical phenotypes typically associated with preterm birth (i.e., necrotizing enterocolitis) with gut microbiota, and the potential directions for future studies in this field are finally discussed.
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