期刊
FRONTIERS IN CELLULAR AND INFECTION MICROBIOLOGY
卷 12, 期 -, 页码 -出版社
FRONTIERS MEDIA SA
DOI: 10.3389/fcimb.2022.759306
关键词
fecal microbiota transplantation; non-alcoholic fatty liver disease; gut microbiota; lean NAFLD; obese NAFLD
资金
- Deans Fund of the Seventh Affiliated Hospital of Southern Medical University [2021YZJJ005]
- Medical scientific research project of Foshan Health Bureau [20220809A010452]
Fecal microbiota transplantation (FMT) can attenuate fat accumulation in patients with non-alcoholic fatty liver disease (NAFLD) by improving gut microbiota dysbiosis. Significant differences in clinical features and gut microbiota were observed between lean and obese NAFLD patients, with FMT showing better effects in lean NAFLD patients.
Background and AimsThe clinical efficacy of fecal microbiota transplantation (FMT) in patients with non-alcoholic fatty liver disease (NAFLD) and the variant effects of FMT on lean and obese NAFLD patients remain elusive. Our study aimed to determine the clinical efficacy and safety of FMT for patients with NAFLD, elucidating its different influences on lean and obese patients with NAFLD. MethodsWe performed a randomized and controlled clinical trial. Patients in the non-FMT group were administered oral probiotics. In the FMT group, patients were randomized to receive FMT with donor stool (heterologous) via colonoscopy, followed by three enemas over 3 days. Both groups were also required to maintain a healthy diet and keep regular exercise for more than 40 min every day. They returned to the hospital for reexamination 1 month after treatment. ResultsFMT can decrease the fat accumulation in the liver by improving the gut microbiota dysbiosis, thus attenuating fatty liver disease. Significant differences in the clinical features and gut microbiota between lean and obese NAFLD patients were unveiled. Moreover, FMT had better effects on gut microbiota reconstruction in lean NAFLD than in obese NAFLD patients. ConclusionsFMT could successfully improve the therapeutic effects on patients with NAFLD, and its clinical efficacy was higher in lean NAFLD than in obese NAFLD patients.
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