Mucus and Mucins: The Underappreciated Host Defence System

The mucosal surfaces that form the boundary between the external environment and the underlying tissue are protected by a mucus barrier. Mucin glycoproteins, both secreted and cell surface mucins, are the major components of the barrier. They can exclude pathogens and toxins while hosting the commensal bacteria. In this review, we highlight the dynamic function of the mucins and mucus during infection, how this mucosal barrier is regulated, and how pathogens have evolved mechanisms to evade this defence system.

Automated summary

This article focuses on the dynamic function of mucins and mucus during infection, the regulation of the mucosal barrier, and how pathogens have evolved mechanisms to evade this defense system.