The reservoir of latent HIV

The persistence of latent reservoir of the human immunodeficiency virus (HIV) is currently the major challenge in curing HIV infection. After HIV infects the human body, the latent HIV is unable to be recognized by the body's immune system. Currently, the widely adopted antiretroviral therapy (ART) is also unble to eliminate it, thus hindering the progress of HIV treatment. This review discusses the existence of latent HIV vault for HIV treatment, its formation and factors affecting its formation, cell, and tissue localization, methods for detection and removing latent reservoir, to provide a comprehensive understanding of latent HIV vault, in order to assist in the future research and play a potential role in achieving HIV treatment.

Automated summary

The persistence of latent HIV reservoir is a major challenge in curing HIV infection. Current antiretroviral therapy is unable to eliminate the latent HIV, hindering the progress of HIV treatment. This review aims to provide a comprehensive understanding of the existence, formation, localization, detection, and removal methods of latent HIV reservoir, in order to assist future research and potential role in achieving HIV treatment.