期刊
BIOMED RESEARCH INTERNATIONAL
卷 2022, 期 -, 页码 -出版社
HINDAWI LTD
DOI: 10.1155/2022/4271358
关键词
-
资金
- Royal Physiographic Society of Lund [40616/2019/09/25]
- Anara AB, Trelleborg, Sweden
The article describes a study on the effects of α-amylase on human neuroblastoma cells. The research shows that α-amylase can inhibit cell proliferation and directly impact glucose uptake, suggesting its potential as an anticancer agent for neuroblastoma treatment.
The present article describes a study of the effects of alpha-amylase (alpha-amylase) on the human neuroblastoma (NB) cell lines SH-SY5Y, IMR-32, and LA-N-1. NB is the most common malignancy diagnosed in infants younger than 12 months. Some clinical observations revealed an inverse association between the risk of NB development and breastfeeding. alpha-Amylase which is present in breast milk was shown to have anticancer properties already in the beginning of the 20th century. Data presented here show that pancreatic alpha-amylase inhibits cell proliferation and has a direct impact on glucose uptake in the human NB cell lines. Our results point out the importance of further research which could elucidate the alpha-amylase mode of action and justify the presence of this enzyme in breast milk as a possible inhibitor of NB development. alpha-Amylase can be thus recognized as a potential safe and natural mild/host anticancer agent minimizing chemotherapy-related toxicity in the treatment of NB.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据