期刊
ASIAN JOURNAL OF ORGANIC CHEMISTRY
卷 11, 期 10, 页码 -出版社
WILEY-V C H VERLAG GMBH
DOI: 10.1002/ajoc.202200396
关键词
dihydroquinazolinone; heterocycles; indazolone; N-N bond cleavage; ring expansion
资金
- Department of Pharmaceuticals, Ministry of Chemicals and Fertilizers, Govt. of India f
We disclose a practical and efficient strategy to synthesize 2,3-dihydroquinazolin-4-(1H)-one derivatives by inserting one carbon into a cyclic N-N bond. The developed protocol is characterized by its simple operation procedures and the ability to produce pharmaceutically useful compounds. Mechanistic studies demonstrate that the predicted intramolecular rearrangement occurs through consecutive ring-opening and cyclization sequences. Additionally, a gram-scale reaction and synthetic transformation of products to quinazolinone derivatives have been presented.
We disclose a practical and efficient strategy for the expedient synthesis of 2,3-dihydroquinazolin-4-(1H)-one derivatives by one carbon insertion into cyclic N-N bond. Spontaneous manipulations with operationally simple procedures furnishing pharmaceutically useful compounds are key features of the developed protocol. Mechanistic studies reveal that the predicted intramolecular rearrangement occurs via consecutive ring-opening and cyclization sequences. A gram-scale reaction and synthetic transformation of products to quinazolinone derivatives have also been demonstrated during the course of the study.
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