期刊
POLYMERS
卷 14, 期 14, 页码 -出版社
MDPI
DOI: 10.3390/polym14142761
关键词
micropatterned surface; micropattern; cell morphology; spreading area; elongation; breast cancer cells; MDR; chemoresistance; doxorubicin
资金
- JSPS KAKENHI [21H03830, 21H03813]
Cell morphology can influence breast cancer cell resistance to anti-cancer drugs by affecting cytoskeletal organization, DNA synthesis activity, and P-glycoprotein expression. Larger breast cancer cells with better assembled actin filaments and higher DNA synthesis activity showed higher resistance to doxorubicin, suggesting a correlation between cell morphology and drug resistance.
Cell morphology has been widely investigated for its influence on the functions of normal cells. However, the influence of cell morphology on cancer cell resistance to anti-cancer drugs remains unclear. In this study, micropatterned surfaces were prepared and used to control the spreading area and elongation of human breast cancer cell line. The influences of cell adhesion area and elongation on resistance to doxorubicin were investigated. The percentage of apoptotic breast cancer cells decreased with cell spreading area, while did not change with cell elongation. Large breast cancer cells had higher resistance to doxorubicin, better assembled actin filaments, higher DNA synthesis activity and higher expression of P-glycoprotein than small breast cancer cells. The results suggested that the morphology of breast cancer cells could affect their resistance to doxorubicin. The influence was correlated with cytoskeletal organization, DNA synthesis activity and P-glycoprotein expression.
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