☆ 4.7 Article

Design and Immunoinformatic Assessment of Candidate Multivariant mRNA Vaccine Construct against Immune Escape Variants of SARS-CoV-2

POLYMERS (2022)

相关参考文献

注意：仅列出部分参考文献，下载原文获取全部文献信息。

Article Biology

Structure-guided design of multi-epitopes vaccine against variants of concern (VOCs) of SARS-CoV-2 and validation through In silico cloning and immune simulations

Fahad Humayun et al.

Summary: SARS-CoV-2 is the cause of the current pandemic, with symptoms including fever, runny nose, cough, and dyspnea in COVID-19 patients. Various vaccines are available, but certain variants like B.1.351 show resistance to existing vaccines, leading to research efforts focusing on designing new vaccines.

COMPUTERS IN BIOLOGY AND MEDICINE (2022)

添加到收藏夹

Letter Medicine, General & Internal

Antibody Response and Variant Cross-Neutralization After SARS-CoV-2 Breakthrough Infection

Timothy A. Bates et al.

JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION (2022)

添加到收藏夹

Letter Medicine, General & Internal

Reduced neutralisation of SARS-CoV-2 omicron B.1.1.529 variant by post-immunisation serum

Wanwisa Dejnirattisai et al.

LANCET (2022)

添加到收藏夹

Article Cell Biology

The SARS-CoV-2 Lambda variant exhibits enhanced infectivity and immune resistance

Izumi Kimura et al.

Summary: This study reveals the increased infectivity and antibody evasion mechanism of the SARS-CoV-2 Lambda variant using pseudoviruses. The spike protein of the Lambda variant is more infectious than other variants due to specific mutations, and the RSYLTPGD246-253N mutation is responsible for antibody evasion and enhanced infection.

CELL REPORTS (2022)

添加到收藏夹

Article Immunology

Omicron: A Heavily Mutated SARS-CoV-2 Variant Exhibits Stronger Binding to ACE2 and Potently Escapes Approved COVID-19 Therapeutic Antibodies

Masaud Shah et al.

Summary: The new SARS-CoV-2 variant Omicron has enhanced transmissibility and multiple mutations that may weaken the effectiveness of therapeutic antibodies. Computational studies have shown that Omicron binds to ACE2 with a higher strength and specific mutations contribute significantly to the binding energies. These mutations also result in a drop in the electrostatic potential between RBDOmic and monoclonal antibodies, particularly etesevimab, bamlanivimab, and CT-p59. Sotrovimab, which targets a conserved epitope on the Spike protein, could be used as a cocktail therapy for Omicron-driven COVID-19.

FRONTIERS IN IMMUNOLOGY (2022)

添加到收藏夹

Article Biochemistry & Molecular Biology

Circular RNA vaccines against SARS-CoV-2 and emerging variants

Liang Qu et al.

Summary: This study reports a circular RNA vaccine that provides potent protection against SARS-CoV-2 by eliciting neutralizing antibodies and T cell responses. The circRNA vaccine exhibits higher and more durable antigen production compared to mRNA vaccines and shows efficacy against the current variants of concern.

CELL (2022)

添加到收藏夹

Article Immunology

Mechanisms of innate and adaptive immunity to the Pfizer-BioNTech BNT162b2 vaccine

Chunfeng Li et al.

Summary: The BNT162b2 mRNA vaccine stimulates potent antibody and antigen-specific T cell responses, as well as enhanced innate responses after secondary immunization. Circulating IFN-gamma is mainly produced by natural killer cells and CD8(+) T cells in the draining lymph nodes. The CD8(+) T cell response is dependent on type I interferon-dependent MDA5 signaling.

NATURE IMMUNOLOGY (2022)

添加到收藏夹

Letter Immunology

Significantly reduced abilities to cross-neutralize SARS-CoV-2 variants by sera from convalescent COVID-19 patients infected by Delta or early strains

Ting Pan et al.

CELLULAR & MOLECULAR IMMUNOLOGY (2021)

添加到收藏夹

Article Medicine, General & Internal

Safety and efficacy of the ChAdOx1 nCoV-19 vaccine (AZD1222) against SARS-CoV-2: an interim analysis of four randomised controlled trials in Brazil, South Africa, and the UK

Merryn Voysey et al.

Summary: The ChAdOx1 nCoV-19 vaccine has been shown to have an acceptable safety profile and effectiveness against symptomatic COVID-19, with higher efficacy observed in the group that received a low dose followed by a standard dose.

LANCET (2021)

添加到收藏夹

Article Biochemistry & Molecular Biology

RCSB Protein Data Bank: powerful new tools for exploring 3D structures of biological macromolecules for basic and applied research and education in fundamental biology, biomedicine, biotechnology, bioengineering and energy sciences

Stephen K. Burley et al.

Summary: RCSB PDB, as the US data center for the global PDB archive, provides free access to 3D macromolecular structure data for millions of users worldwide, including educators, students, and the general public, integrating over 40 external biodata resources. The redesigned website now features improved search functionality and easier access to PDB data, showcasing new structures relevant to the understanding and addressing of the COVID-19 pandemic.

NUCLEIC ACIDS RESEARCH (2021)

添加到收藏夹

Article Biochemistry & Molecular Biology

Multiple SARS-CoV-2 variants escape neutralization by vaccine-induced humoral immunity

Wilfredo F. Garcia-Beltran et al.

Summary: New variants of SARS-CoV-2 show high resistance to vaccine neutralization, with some able to escape vaccine responses with just a few mutations, highlighting the importance of developing broadly protective measures against variants.

CELL (2021)

添加到收藏夹

Article Biochemistry & Molecular Biology

Evidence of escape of SARS-CoV-2 variant B.1.351 from natural and vaccine-induced sera

Daming Zhou et al.

Summary: The race to develop vaccines against SARS-CoV-2 variants, such as B.1.1.7, B.1.351, and P.1, is ongoing as these variants have mutations in the spike protein, potentially leading to immune escape. A structure-function analysis of B.1.351 revealed tighter ACE2 binding and widespread evasion from monoclonal antibody neutralization, particularly driven by the E484K mutation.

CELL (2021)

添加到收藏夹

Article Medicine, General & Internal

Safety and efficacy of an rAd26 and rAd5 vector-based heterologous prime-boost COVID-19 vaccine: an interim analysis of a randomised controlled phase 3 trial in Russia

Denis Y. Logunov et al.

Summary: The Gam-COVID-Vac vaccine showed 91.6% efficacy against COVID-19 in the phase 3 trial, with good safety and tolerability in a large cohort of participants.

LANCET (2021)

添加到收藏夹

Article Multidisciplinary Sciences

Sensitivity of SARS-CoV-2 B.1.1.7 to mRNA vaccine-elicited antibodies

Dami A. Collier et al.

Summary: The B.1.1.7 variant of SARS-CoV-2 exhibited reduced neutralization by vaccines and antibodies from recovered COVID-19 patients, with a more substantial loss seen when introducing the E484K mutation. This mutation poses a threat to the efficacy of the BNT162b2 vaccine.

NATURE (2021)

添加到收藏夹

Article Multidisciplinary Sciences

Antibody resistance of SARS-CoV-2 variants B.1.351 and B.1.1.7

Pengfei Wang et al.

Summary: The COVID-19 pandemic has had global repercussions, with promising vaccines and monoclonal antibody therapies. However, newly detected variants of SARS-CoV-2 present challenges to these treatment options.

NATURE (2021)

添加到收藏夹

Article Biochemistry & Molecular Biology

Resistance of SARS-CoV-2 variants to neutralization by monoclonal and serum-derived polyclonal antibodies

Rita E. Chen et al.

Summary: The study analyzed antibody neutralization activity against a panel of authentic isolates and chimeric SARS-CoV-2 variants, showing significantly reduced neutralizing activity against the B.1.351 variant first identified in South Africa. Antibodies targeting the receptor-binding domain and N-terminal domain, monoclonal antibodies, convalescent sera, and mRNA vaccine-induced immune sera exhibited decreased inhibitory activity against viruses with an E484K spike mutation, suggesting a need for updated monoclonal antibodies or vaccine adjustments to prevent loss of protection against emerging variants.

NATURE MEDICINE (2021)

添加到收藏夹

Article Biochemistry & Molecular Biology

SARS-CoV-2 501Y.V2 escapes neutralization by South African COVID-19 donor plasma

Constantinos Kurt Wibmer et al.

Summary: The SARS-CoV-2 virus in the B.1.351 variant discovered in South Africa can evade neutralization by most antibodies when expressed, but does not affect binding by convalescent plasma. This suggests the potential for reinfection with antigenically distinct variants and predicts reduced efficacy of spike-based vaccines.

NATURE MEDICINE (2021)

添加到收藏夹

Article Multidisciplinary Sciences

Molecular basis of immune evasion by the Delta and Kappa SARS-CoV-2 variants

Matthew McCallum et al.

Summary: The transmission of SARS-CoV-2 leads to the emergence of variants, such as the B.1.617.2 (Delta) variant, which dampens the in vitro potency of vaccine-elicited serum neutralizing antibodies. Mutations in the B.1.617.1 (Kappa) and Delta spike glycoproteins alter key antigenic sites, affecting the recognition by monoclonal antibodies. The angiotensin-converting enzyme 2 binding affinities of Kappa and Delta are comparable to the Wuhan-Hu-1 isolate, while Delta+ exhibits significantly reduced affinity.

SCIENCE (2021)

添加到收藏夹

Article Multidisciplinary Sciences

Recurrent deletions in the SARS-CoV-2 spike glycoprotein drive antibody escape

Kevin R. McCarthy et al.

Summary: The translation above discusses zoonotic pandemics caused by animal viruses spilling over into highly susceptible human populations, specifically focusing on the evolution of coronaviruses in human hosts and the impact of recurrent deletions in the spike glycoprotein on antibody epitopes. These studies help understand the antigenic evolution and adaptive evolution of SARS-CoV-2.

SCIENCE (2021)

添加到收藏夹

Article Multidisciplinary Sciences

A single-dose mRNA vaccine provides a long-term protection for hACE2 transgenic mice from SARS-CoV-2

Qingrui Huang et al.

Summary: A nucleoside-modified mRNA vaccine encoding SARS-CoV-2 RBD, termed mRNA-RBD, provides long-term protection with a single immunization, inducing robust immune responses. Animal studies demonstrate that neutralizing antibodies induced by mRNA vaccine can be maintained for at least 6.5 months, providing protection in transfer studies.

NATURE COMMUNICATIONS (2021)

添加到收藏夹

Article Microbiology

Reduced neutralisation of the Delta (B.1.617.2) SARS-CoV-2 variant of concern following vaccination

Chris Davis et al.

Summary: Vaccines have proven to be effective in controlling hospitalisation and deaths associated with SARS-CoV-2 infection, but the emergence of viral variants with novel antigenic profiles raises concerns. Serum from vaccine recipients showed reduced neutralisation against SARS-CoV-2 variants like B.1.617.1, B.1.617.2, and B.1.351. The BNT162b2 vaccine induced higher neutralising antibody titres compared to the ChAdOx1 vaccine, but both vaccines showed decreased efficacy against certain variants.

PLOS PATHOGENS (2021)

添加到收藏夹

Article Biochemistry & Molecular Biology

N-terminal domain antigenic mapping reveals a site of vulnerability for SARS-CoV-2

Matthew McCallum et al.

Summary: The study identifies 41 human monoclonal antibodies that recognize the N-terminal domain of the SARS-CoV-2 spike protein and exhibit strong neutralizing activity. These antibodies inhibit cell-to-cell fusion, activate effector functions, and protect animals from virus challenge, highlighting the importance of NTD-specific neutralizing antibodies for protective immunity and vaccine development. Several SARS-CoV-2 variants with mutations in the NTD supersite suggest ongoing selective pressure on the virus.

CELL (2021)

添加到收藏夹

Article Biochemistry & Molecular Biology

Emergence and rapid transmission of SARS-CoV-2 B.1.1.7 in the United States

Nicole L. Washington et al.

Summary: The highly transmissible B.1.1.7 variant of SARS-CoV-2, first identified in the United Kingdom, has been spreading in the United States with multiple introductions as early as late November 2020. The variant shows a logistic growth rate with roughly weekly doubling and increased transmission, requiring immediate action to minimize COVID-19 morbidity and mortality.

CELL (2021)

添加到收藏夹

Article Biochemistry & Molecular Biology

Transmission, infectivity, and neutralization of a spike L452R SARS-CoV-2 variant

Xianding Deng et al.

Summary: A new SARS-CoV-2 variant named B.1.427/B.1.429 was identified in California, with increased transmissibility and carrying three mutations in spike protein, including L452R substitution. The variant emerged in May 2020 and became predominant in sequenced cases from September 2020 to January 2021. In vivo viral shedding was increased and antibody neutralization decreased, calling for further investigation.

CELL (2021)

添加到收藏夹

Review Pharmacology & Pharmacy

mRNA-lipid nanoparticle COVID-19 vaccines: Structure and stability

Linde Schoenmaker et al.

Summary: The current mRNA-lipid nanoparticle COVID-19 vaccines require storage at low temperatures due to instability. Improving mRNA nucleotide composition, understanding the impact of mRNA environment within LNPs, and exploring drying techniques can enhance vaccine stability.

INTERNATIONAL JOURNAL OF PHARMACEUTICS (2021)

添加到收藏夹

Review Biochemistry & Molecular Biology

COVID-19 mRNA vaccines

Qinrui Huang et al.

Summary: The ongoing COVID-19 pandemic has accelerated the development of mRNA vaccines, with positive results reported and future challenges ahead.

JOURNAL OF GENETICS AND GENOMICS (2021)

添加到收藏夹

Editorial Material Virology

Bioinformatics and immunoinformatics to support COVID-19 vaccine development

Stephanie Ishack et al.

Summary: The rapid spread of SARS-CoV-2 has resulted in a high number of infections and deaths, highlighting the urgent need for more rapid and precise vaccine design using computational methods.

JOURNAL OF MEDICAL VIROLOGY (2021)

添加到收藏夹

Article Infectious Diseases

Genomic characteristics and clinical effect of the emergent SARS-CoV-2 B.1.1.7 lineage in London, UK: a whole-genome sequencing and hospital-based cohort study

Dan Frampton et al.

Summary: This study describes the emergence of the B.1.1.7 variant of concern, its virological characteristics, and clinical severity in patients. Increased viral load was found in B.1.1.7 infection, but no association with severe disease was identified in the hospitalized cohort.

LANCET INFECTIOUS DISEASES (2021)

添加到收藏夹

Review Biochemistry & Molecular Biology

mRNA therapeutics in cancer immunotherapy

Jan D. Beck et al.

Summary: Synthetic mRNA serves as a versatile template for protein synthesis and has a wide range of pharmaceutical applications, including cancer immunotherapy. Strategies such as stimulating pattern recognition receptors and nucleoside modification enhance the effectiveness and safety of mRNA vaccines.

MOLECULAR CANCER (2021)

添加到收藏夹

Article Multidisciplinary Sciences

Neutralizing antibody vaccine for pandemic and pre-emergent coronaviruses

Kevin O. Saunders et al.

Summary: This study demonstrates that immunizing macaques with nanoparticles conjugated with the receptor-binding domain of SARS-CoV-2, adjuvanted with 3M-052 and alum, can elicit cross-neutralizing antibody responses against various coronaviruses and provide protection against SARS-CoV-2. Nucleoside-modified mRNAs encoding stabilized spike proteins also induce antibody responses against different coronaviruses, suggesting potential for developing vaccines against multiple betacoronaviruses in the future.

NATURE (2021)

添加到收藏夹

Article Biochemistry & Molecular Biology

Sensitivity of infectious SARS-CoV-2 B.1.1.7 and B.1.351 variants to neutralizing antibodies

Delphine Planas et al.

Summary: The ability of convalescent sera from individuals with coronavirus disease 2019 and those vaccinated with BNT162b2 to neutralize SARS-CoV-2 variants B1.1.7 and B.1.351 decreases, but increases after two vaccine doses. The study found that the B.1.1.7 and B.1.351 variants may have acquired partial resistance to neutralizing antibodies generated by natural infection or vaccination, particularly in individuals with low antibody levels. This suggests that the B.1.351 variant may pose a greater risk of infection in immunized individuals.

NATURE MEDICINE (2021)

添加到收藏夹

Editorial Material Multidisciplinary Sciences

THE DREAM VACCINE

Jon Cohen

Summary: Researchers are working on developing vaccines that can protect against multiple coronaviruses at once, aiming to enhance immunity against future coronavirus infectious diseases.

SCIENCE (2021)

添加到收藏夹

Article Multidisciplinary Sciences

Reduced sensitivity of SARS-CoV-2 variant Delta to antibody neutralization

Delphine Planas et al.

Summary: The SARS-CoV-2 B.1.617 Delta variant, first identified in India in 2020, has become dominant in some regions and is spreading to many countries. This variant shows resistance to certain monoclonal antibodies and antibodies in convalescent sera, as well as reduced neutralization by some COVID-19 vaccines. Administration of two doses of the vaccine is needed for a neutralizing response against the Delta variant.

NATURE (2021)

添加到收藏夹

Review Microbiology

SARS-CoV-2 variants, spike mutations and immune escape

William T. Harvey et al.

Summary: The evolution of SARS-CoV-2 has been characterized by the emergence of mutations and variants that impact virus characteristics. Manufacturers are preparing for possible updates to vaccines in response to changes in the virus population, and it is crucial to monitor genetic and antigenic changes alongside experiments to understand the impacts of mutations.

NATURE REVIEWS MICROBIOLOGY (2021)

添加到收藏夹

Article Immunology

SARS-CoV-2 Proteome Harbors Peptides Which Are Able to Trigger Autoimmunity Responses: Implications for Infection, Vaccination, and Population Coverage

Mohsen Karami Fath et al.

Summary: The study found that SARS-CoV-2 shares 23 peptides with the human proteome, with 21 having experimentally confirmed T-cell and B-cell epitopes. Among them, four peptides were identified as the most harmful, potentially increasing the incidence of autoimmune diseases in populations with specific HLA types.

FRONTIERS IN IMMUNOLOGY (2021)

添加到收藏夹

Article Microbiology

SARS-CoV-2 Spike Mutations, L452R, T478K, E484Q and P681R, in the Second Wave of COVID-19 in Maharashtra, India

Sarah Cherian et al.

Summary: Genomic epidemiology and whole genome sequencing were used to investigate the transmission and evolution of the SARS-CoV-2 virus during the global pandemic. The study identified new variants B.1.617.1 and B.1.617.2 in India, responsible for the second wave of COVID-19 in Maharashtra, with B.1.617.2 designated as a VOC delta and B.1.617.1 as a variant of interest kappa. Monitoring of these and emerging variants in India is crucial for public health.

MICROORGANISMS (2021)

添加到收藏夹

Letter Biochemistry & Molecular Biology

SARS-CoV-2 Omicron strain exhibits potent capabilities for immune evasion and viral entrance

Xiantao Zhang et al.

SIGNAL TRANSDUCTION AND TARGETED THERAPY (2021)

添加到收藏夹

Review Physiology

DNA Sensing in the Innate Immune Response

Benoit Briard et al.

PHYSIOLOGY (2020)

添加到收藏夹

Article Biochemistry & Molecular Biology

Structure, Function, and Antigenicity of the SARS-CoV-2 Spike Glycoprotein

Alexandra C. Walls et al.

CELL (2020)

添加到收藏夹

Article Multidisciplinary Sciences

Structure of the SARS-CoV-2 spike receptor-binding domain bound to the ACE2 receptor

Jun Lan et al.

NATURE (2020)

添加到收藏夹

Article Biochemistry & Molecular Biology

A Thermostable mRNA Vaccine against COVID-19

Na-Na Zhang et al.

CELL (2020)

添加到收藏夹

Article Chemistry, Multidisciplinary

Leveraging mRNA Sequences and Nanoparticles to Deliver SARS-CoV-2 Antigens In Vivo

Chunxi Zeng et al.

ADVANCED MATERIALS (2020)

添加到收藏夹

Article Multidisciplinary Sciences

A neutralizing human antibody binds to the N-terminal domain of the Spike protein of SARS-CoV-2

Xiangyang Chi et al.

SCIENCE (2020)

添加到收藏夹

Review Biochemistry & Molecular Biology

mRNA Vaccine Era-Mechanisms, Drug Platform and Clinical Prospection

Shuqin Xu et al.

INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES (2020)

添加到收藏夹

Article Multidisciplinary Sciences

SARS-CoV-2 neutralizing antibody structures inform therapeutic strategies

Christopher O. Barnes et al.

NATURE (2020)

添加到收藏夹

Article Biochemistry & Molecular Biology

Designing a novel mRNA vaccine against SARS-CoV-2: An immunoinformatics approach

Ishtiaque Ahammad et al.

INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES (2020)

添加到收藏夹

Review Biochemistry & Molecular Biology

A systematic review of SARS-CoV-2 vaccine candidates

Yetian Dong et al.

SIGNAL TRANSDUCTION AND TARGETED THERAPY (2020)

添加到收藏夹

Article Biology

GC content shapes mRNA storage and decay in human cells

Maite Courel et al.

ELIFE (2019)

添加到收藏夹

Article Immunology

Modified mRNA-Based Vaccines Elicit Robust Immune Responses and Protect Guinea Pigs From Ebola Virus Disease

Michelle Meyer et al.

JOURNAL OF INFECTIOUS DISEASES (2018)

添加到收藏夹

Review Biotechnology & Applied Microbiology

mRNA vaccines - a new era in vaccinology

Norbert Pardi et al.

NATURE REVIEWS DRUG DISCOVERY (2018)

添加到收藏夹

Article Biochemistry & Molecular Biology

SWISS-MODEL: homology modelling of protein structures and complexes

Andrew Waterhouse et al.

NUCLEIC ACIDS RESEARCH (2018)

添加到收藏夹

Review Endocrinology & Metabolism

Overview of MicroRNA Biogenesis, Mechanisms of Actions, and Circulation

Jacob O'Brien et al.

FRONTIERS IN ENDOCRINOLOGY (2018)

添加到收藏夹

Article Medicine, General & Internal

Safety and immunogenicity of a mRNA rabies vaccine in healthy adults: an open-label, non-randomised, prospective, first-in-human phase 1 clinical trial

Martin Alberer et al.

LANCET (2017)

添加到收藏夹

Article Biotechnology & Applied Microbiology

Preclinical and Clinical Demonstration of Immunogenicity by mRNA Vaccines against H10N8 and H7N9 Influenza Viruses

Kapil Bahl et al.

MOLECULAR THERAPY (2017)

添加到收藏夹

Article Biochemistry & Molecular Biology

Modified mRNA Vaccines Protect against Zika Virus Infection

Justin M. Richner et al.

CELL (2017)

添加到收藏夹

Article Multidisciplinary Sciences

Data, disease and diplomacy: GISAID's innovative contribution to global health

Stefan Elbe et al.

GLOBAL CHALLENGES (2017)

添加到收藏夹

Article Chemistry, Multidisciplinary

N1-methylpseudouridine-incorporated mRNA outperforms pseudouridine-incorporated mRNA by providing enhanced protein expression and reduced immunogenicity in mammalian cell lines and mice

Oliwia Andries et al.

JOURNAL OF CONTROLLED RELEASE (2015)

添加到收藏夹

Article Biochemistry & Molecular Biology

miRDB: an online resource for microRNA target prediction and functional annotations

Nathan Wong et al.

NUCLEIC ACIDS RESEARCH (2015)

添加到收藏夹

Article Multidisciplinary Sciences

Molecular mechanisms for the regulation of histone mRNA stem-loop-binding protein by phosphorylation

Jun Zhang et al.

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2014)

添加到收藏夹

Article Genetics & Heredity

Modelling the structure of full-length Epstein-Barr virus nuclear antigen 1

Mushtaq Hussain et al.

VIRUS GENES (2014)

添加到收藏夹

Review Biochemistry & Molecular Biology

Linkers in the structural biology of protein-protein interactions

Vishnu Priyanka Reddy Chichili et al.

PROTEIN SCIENCE (2013)

添加到收藏夹

Article Biochemical Research Methods

Reliable B Cell Epitope Predictions: Impacts of Method Development and Improved Benchmarking

Jens Vindahl Kringelum et al.

PLOS COMPUTATIONAL BIOLOGY (2012)

添加到收藏夹

Article Biochemistry & Molecular Biology

Generating the optimal mRNA for therapy: HPLC purification eliminates immune activation and improves translation of nucleoside-modified, protein-encoding mRNA

Katalin Kariko et al.

NUCLEIC ACIDS RESEARCH (2011)

添加到收藏夹

Article Biochemical Research Methods

MolProbity: all-atom structure validation for macromolecular crystallography

Vincent B. Chen et al.

ACTA CRYSTALLOGRAPHICA SECTION D-STRUCTURAL BIOLOGY (2010)

添加到收藏夹

Article Immunology

Immunologic activity and safety of autologous HIV RNA-electroporated dendritic cells in HIV-1 infected patients receiving antiretroviral therapy

Jean-Pierre Routy et al.

CLINICAL IMMUNOLOGY (2010)

添加到收藏夹

Article Multidisciplinary Sciences

Mammalian microRNAs predominantly act to decrease target mRNA levels

Huili Guo et al.

NATURE (2010)

添加到收藏夹

Article Multidisciplinary Sciences

Computational Immunology Meets Bioinformatics: The Use of Prediction Tools for Molecular Binding in the Simulation of the Immune System

Nicolas Rapin et al.

PLOS ONE (2010)

添加到收藏夹

Article Biochemistry & Molecular Biology

The Vienna RNA Websuite

Andreas R. Gruber et al.

NUCLEIC ACIDS RESEARCH (2008)

添加到收藏夹

Article Biochemical Research Methods

Clustal W and clustal X version 2.0

M. A. Larkin et al.

BIOINFORMATICS (2007)

添加到收藏夹

Article Biochemistry & Molecular Biology

ExPASy: the proteomics server for in-depth protein knowledge and analysis

E Gasteiger et al.

NUCLEIC ACIDS RESEARCH (2003)

添加到收藏夹

Article Multidisciplinary Sciences

Inhibition of proteasomal degradation by the Gly-Ala repeat of Epstein-Barr virus is influenced by the length of the repeat and the strength of the degradation signal

NP Dantuma et al.

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2000)

添加到收藏夹

© Peeref 2019-2024. All rights reserved.