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In Vivo Bone Tissue Engineering Strategies: Advances and Prospects

POLYMERS (2022)

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Article Chemistry, Applied

Osteogenic differentiation of human mesenchymal stem cells on substituted calcium phosphate/chitosan composite scaffold

Antonia Ressler et al.

Summary: Ionic substitutions in composite materials have shown promising potential in enhancing the biological performance for bone tissue engineering applications. This study focused on multi-substituted organic/inorganic scaffolds and demonstrated that these scaffolds have high stability and can promote osteogenic potential of human mesenchymal stem cells. Results highlighted the beneficial effect of ionic substitutions on cells and tissues.

CARBOHYDRATE POLYMERS (2022)

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Review Biochemistry & Molecular Biology

Bioengineered Living Bone Grafts-A Concise Review on Bioreactors and Production Techniques In Vitro

Paulina Kazimierczak et al.

Summary: Bone fractures carry significant risks, and proper bone healing methods are crucial for successful recovery. Bone tissue engineering (BTE) offers promising approaches to restore bone defects by combining bone scaffolds with cells and healing promotive factors. This review highlights the latest findings in biomaterials, cells, and techniques used for producing living bone grafts in vitro, with particular attention to bioreactor systems such as perfusion, rotating, and spinner flask bioreactors. Despite limitations, bioreactor systems prove to be excellent platforms for bioengineering living bone grafts for bone fracture regeneration.

INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES (2022)

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Article Chemistry, Physical

Mineralization in a Critical Size Bone-Gap in Sheep Tibia Improved by a Chitosan-Calcium Phosphate-Based Composite as Compared to Predicate Device

Gissur Orlygsson et al.

Summary: This study compared the efficacy of an injectable product containing a 50% deacetylated chitin derivative with an existing product for tissue engineering purposes. Results showed that the injectable product had higher new bone formation and less fibrous tissue compared to the existing product. The study demonstrated the potential of deacetylated chitin derivatives in stimulating bone formation.

MATERIALS (2022)

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Review Biotechnology & Applied Microbiology

Scaffold-Based Tissue Engineering Strategies for Osteochondral Repair

Jiang-Nan Fu et al.

Summary: This article reviews the advances in osteochondral tissue engineering and discusses various strategies including scaffold design, material types, fabrication techniques, and functional properties. Although there are still challenges and difficulties, research in this field is of great importance for repairing OC defects.

FRONTIERS IN BIOENGINEERING AND BIOTECHNOLOGY (2022)

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Review Biotechnology & Applied Microbiology

Rare earth smart nanomaterials for bone tissue engineering and implantology: Advances, challenges, and prospects

Duraipandy Natarajan et al.

Summary: The challenges in bone graft and prosthetic implant designing for clinical application are being addressed with the revolutionary advances of nanotechnology, particularly in the use of rare earth (RE) materials with unique properties for tissue engineering. Researchers have developed smart nano-biomaterials using RE materials for bone tissue engineering and implantology applications, exploring their molecular mechanisms and potential for novel strategies. The biomedical applications of micro or nano-scale RE materials have shown promise in providing cost-effective solutions in bone tissue engineering.

BIOENGINEERING & TRANSLATIONAL MEDICINE (2022)

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Article Dentistry, Oral Surgery & Medicine

Periosteal Flaps Enhance Prefabricated Engineered Bone Reparative Potential

A. G. Abu-Shahba et al.

Summary: The clinical translation of bone tissue engineering for reconstructing large bone defects faces challenges, but the use of in vivo bioreactors (IVB) shows promise in prefabricating new prevascularized tissues. This study on sheep demonstrated that periosteal flaps enhance the reconstructive potential of prefabricated tissue-engineered bone (TEB) flaps, showcasing the regenerative potential of periosteum in mechanically stimulated bony defect microenvironment.

JOURNAL OF DENTAL RESEARCH (2022)

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Article Polymer Science

Biopolymer Material from Human Spongiosa for Regenerative Medicine Application

Ilya L. Tsiklin et al.

Summary: This study investigates the biocompatibility and microstructural properties of demineralized human spongiosa Lyoplast(R) and demonstrates its potential as a bioactive scaffold for articular hyaline cartilage tissue engineering.

POLYMERS (2022)

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Article Medicine, General & Internal

Postoperative Complications and Swallowing Function after Jejunal and Skin Flap Reconstruction for Hypopharyngeal Carcinoma-A Multicenter Retrospective Study

Kunihiko Tokashiki et al.

Summary: This study compared the incidence of perioperative complications and swallowing function between free jejunal flap reconstruction and cutaneous free tissue flap construction. The results showed that cutaneous free tissue flaps had better dietary intake and lower donor site complications.

JOURNAL OF CLINICAL MEDICINE (2022)

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Article Engineering, Biomedical

Nanofibrous scaffolds of ε-polycaprolactone containing Sr/Se-hydroxyapatite/graphene oxide for tissue engineering applications

M. K. Ahmed et al.

Summary: Introducing graphene oxide (GO) into ε-polycaprolactone (PCL) nanofibrous scaffolds can enhance the mechanical properties and promote cell growth. Increasing the concentration of GO in the scaffold can improve toughness and maximum strain, leading to increased cell proliferation and spreading on the scaffold surface.

BIOMEDICAL MATERIALS (2021)

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Article Chemistry, Multidisciplinary

Additive Manufacturing of Material Scaffolds for Bone Regeneration: Toward Application in the Clinics

Charlotte Garot et al.

Summary: This paper reviews the state-of-the-art materials and AM techniques used in the fabrication of 3D-printed bone scaffolds in bone tissue engineering. The advantages and drawbacks of these materials and techniques are highlighted, with specific criteria for material selection identified. Different combinations of materials and AM techniques are found to be most relevant for specific clinical applications.

ADVANCED FUNCTIONAL MATERIALS (2021)

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Article Dentistry, Oral Surgery & Medicine

PLGA plus HA/βTCP Scaffold Incorporating Simvastatin: A Promising Biomaterial for Bone Tissue Engineering

Mariane Beatriz Sordi et al.

Summary: The study aimed to synthesize, characterize, and evaluate the biocompatibility of PLGA+HA/β-TCP scaffolds incorporating simvastatin for bone tissue engineering. The inclusion of simvastatin improved scaffold hydrophilicity and showed adequate structural, chemical, thermal, and biological properties for bone tissue engineering.

JOURNAL OF ORAL IMPLANTOLOGY (2021)

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Article Dentistry, Oral Surgery & Medicine

Retrospective analysis of complications in 190 mandibular resections and simultaneous reconstructions with free fibula flap, iliac crest flap or reconstruction plate: a comparative single centre study

Lucas M. Ritschl et al.

Summary: This study aimed to evaluate the incidence of complications following mandibular reconstruction and analyze contributing factors. Skin perforation was most often detected in the reconstruction plate subgroup, with low BMI and total radiation dosage being the most relevant risk factors. Microvascular bone flaps were found to have fewer skin perforations overall, and BMI and expected radiation dosage should be considered when choosing a reconstructive technique.

CLINICAL ORAL INVESTIGATIONS (2021)

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Article Engineering, Biomedical

Polycaprolactone fibrous electrospun scaffolds reinforced with copper doped wollastonite for bone tissue engineering applications

Mohamed Abudhahir et al.

Summary: The biocomposite scaffold synthesized in this study by combining PCL, Ws, and Cu exhibited micro-fibrous surface morphology and showed potential for promoting bone formation.

JOURNAL OF BIOMEDICAL MATERIALS RESEARCH PART B-APPLIED BIOMATERIALS (2021)

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Review Biochemistry & Molecular Biology

Advances in Growth Factor Delivery for Bone Tissue Engineering

Erica Resende Oliveira et al.

Summary: Tissue engineering and regenerative medicine have addressed some shortcomings in the treatment of bone diseases, particularly in simulating the extracellular matrix and guiding bone repair. Combining scaffolding and growth factors shows great potential in promoting the effectiveness of bone regeneration methods.

INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES (2021)

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Article Materials Science, Biomaterials

3D printing of silk microparticle reinforced polycaprolactone scaffolds for tissue engineering applications

Cian Vyas et al.

Summary: Polycaprolactone (PCL) scaffolds have been enhanced by incorporating Bombyx mori silk microparticles (SMP) as a reinforcing agent, showing improved mechanical properties and interconnectivity. The addition of SMP increased shear thinning and storage modulus, while enhancing cell behaviors such as proliferation and migration. The study demonstrates the potential suitability of SMP-reinforced PCL scaffolds for bone tissue engineering applications.

MATERIALS SCIENCE & ENGINEERING C-MATERIALS FOR BIOLOGICAL APPLICATIONS (2021)

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Article Engineering, Biomedical

Metformin-loaded β-TCP/CTS/SBA-15 composite scaffolds promote alveolar bone regeneration in a rat model of periodontitis

Wanghan Xu et al.

Summary: In this study, a new MET composite scaffold was developed to repair alveolar bone defects in periodontitis. Results showed that the scaffold promoted alveolar bone regeneration in a rat model of periodontitis, indicating a promising strategy for repairing alveolar bone defects in this condition.

JOURNAL OF MATERIALS SCIENCE-MATERIALS IN MEDICINE (2021)

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Review Biotechnology & Applied Microbiology

A review of biomimetic scaffolds for bone regeneration: Toward a cell-free strategy

Sijing Jiang et al.

Summary: In bone grafting, various types of bone grafts and materials are used, with many associated limitations. An ideal scaffold for bone tissue engineering should provide mechanical support while promoting osteogenesis and osteoconduction. Current research focuses on modifying natural or synthetic materials to facilitate bone tissue repair.

BIOENGINEERING & TRANSLATIONAL MEDICINE (2021)

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Review Chemistry, Medicinal

Silica-Based Bioactive Glasses and Their Applications in Hard Tissue Regeneration: A Review

Nuha Al-Harbi et al.

Summary: Regenerative medicine aims to improve tissue repair and restoration processes using bioactive materials like bioactive glass, which is mainly used for bone tissue regeneration. The bioactivity of bioactive glass depends on compositional ratio, and manipulating the content ratio can develop other types of bioactive glasses with controllable chemical durability and affinity with bone.

PHARMACEUTICALS (2021)

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Article Oncology

In Vitro Investigation of Jellyfish Collagen as a Tool in Cell Culture and (Bone) Tissue Engineering

Said Alkildani et al.

Summary: Jellyfish collagen can serve as a competitive alternative to mammalian collagen, providing biocompatibility and adhesive properties for applications in cell culture and tissue engineering.

ANTICANCER RESEARCH (2021)

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Article Chemistry, Physical

Influence of Degradation Product Thickness on the Elastic Stiffness of Porous Absorbable Scaffolds Made from an Bioabsorbable Zn-Mg Alloy

Jannik Buehring et al.

Summary: AM porous scaffolds made of absorbable metals like magnesium, zinc, or iron, designed for orthopaedic applications, show decreasing Young's modulus over time due to product dissolution in a physiological environment. The initial increase in smeared Young's modulus for magnesium-based scaffolds is attributed to a forming substrate layer of degradation products. Even low thicknesses and Young's moduli of the substrate layer significantly increase the smeared Young's modulus under axial compression, as validated by compression tests on Zn1Mg AM scaffolds.

MATERIALS (2021)

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Review Engineering, Biomedical

Applications of marine collagens in bone tissue engineering

Zhidong Lin et al.

Summary: Marine collagen has shown great promise as a biomaterial in bone tissue engineering, displaying excellent biological effects such as promoting osteogenesis, inhibiting inflammation, inducing cartilage differentiation, and improving bone mineral density. Its biocompatibility, biodegradability, ease of extractability, safety, low immunogenicity, and low production costs have made it a popular choice for researchers.

BIOMEDICAL MATERIALS (2021)

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Review Cell Biology

The Potential of FGF-2 in Craniofacial Bone Tissue Engineering: A Review

Anita Novais et al.

Summary: Bone is a hard tissue that constantly renews itself to adapt to the body's demands. The craniofacial area is prone to trauma and pathologies, often leading to large bone damage. Autologous bone grafting is the gold standard for treating these defects, but has drawbacks such as the need for a second surgical site and limitations in bone quantity.

CELLS (2021)

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Review Engineering, Biomedical

Artificial tissue creation under microgravity conditions: Considerations and future applications

Vishal Swaminathan et al.

Summary: Tissue engineering methods under microgravity conditions can promote cell proliferation, differentiation, and changes in cell organization, potentially encouraging the formation of more biosimilar artificial tissues with transplantation potential. However, these benefits are not consistent across all cell types, and the long-term impact of microgravity on tissue development and stability remains an unanswered question. With further research, microgravity tissue engineering may have productive clinical applications for medical and pharmaceutical purposes.

ARTIFICIAL ORGANS (2021)

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Review Biochemistry & Molecular Biology

Pulsed Electromagnetic Fields in Bone Healing: Molecular Pathways and Clinical Applications

Laura Caliogna et al.

Summary: This article reviews the signaling pathways modulated by PEMFs and their clinical applications, based on studies from PubMed and Embase. While identifying cell membrane receptors and pathways involved in bone healing, further research and clinical trials are needed to understand the dose-response relationship and practical applications of PEMFs.

INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES (2021)

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Article Pharmacology & Pharmacy

Supercritical CO2 technology for one-pot foaming and sterilization of polymeric scaffolds for bone regeneration

Victor Santos-Rosales et al.

Summary: A supercritical CO2 sterilization protocol was successfully implemented to prepare and sterilize polymeric scaffolds for regenerative medicine. The sterilization conditions were established after screening against various bacteria and spores, and a transition to compressed foaming was achieved through controlled depressurization. Using this technology, sterile scaffolds with well-controlled pore architecture were obtained, surpassing standard gamma radiation sterilization methods.

INTERNATIONAL JOURNAL OF PHARMACEUTICS (2021)

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Article Biophysics

Flow inside a bone scaffold: Visualization using 3D phase contrast MRI and comparison with numerical simulations

Suyue Han et al.

Summary: This study developed a flow visualization method using Phase-Contrast Magnetic Resonance Imaging (PC-MRI) to measure flow velocities within a 3D-printed microCT-based rendering of a bone scaffold. The experimental results showed quantitative agreement between numerically and experimentally observed flow velocities at different slices of the scaffold, demonstrating the validity of this experimental approach for validating numerical studies and gaining insight into flow behavior inside tissue-engineered scaffolds.

JOURNAL OF BIOMECHANICS (2021)

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Review Cell & Tissue Engineering

Vascularization strategies in tissue engineering approaches for soft tissue repair

Daniela Santos Masson-Meyers et al.

Summary: Insufficient vascularization during tissue repair is a major obstacle in achieving successful clinical outcomes, leading to graft failure and compromised cell viability. Strategies and methods focusing on vascularization, especially cell-based prevascularization, can improve the survival rate and success of tissue-engineered soft tissue constructs.

JOURNAL OF TISSUE ENGINEERING AND REGENERATIVE MEDICINE (2021)

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Article Cell & Tissue Engineering

Tissue-Engineered Hydroxyapatite Bone Scaffold Impregnated with Osteoprogenitor Cells Promotes Bone Regeneration in Sheep Model

Mohd Yazid Bajuri et al.

Summary: The study showed that TEHB scaffold impregnated with osteoprogenitor cells has the potential to promote bone regeneration, with no significant differences compared to autologous bone graft in terms of function and structure, suggesting it can be developed as a bone substitute.

TISSUE ENGINEERING AND REGENERATIVE MEDICINE (2021)

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Article Chemistry, Physical

Modeling of the Human Bone Environment: Mechanical Stimuli Guide Mesenchymal Stem Cell-Extracellular Matrix Interactions

Ana Rita Pereira et al.

Summary: In bone tissue engineering, a bioreactor system was used to mimic the chemical composition, architectural structure, and mechanical environment of native tissue. Dynamic culture conditions improved cell repopulation and ECM production, while mechanical stimuli led to changes in cell shape and stronger adhesion to the matrix in hMSCs.

MATERIALS (2021)

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Review Polymer Science

A Review on Hydrogels with Photothermal Effect in Wound Healing and Bone Tissue Engineering

Xu Zhang et al.

Summary: Photothermal hydrogels show potential in antibacterial action, angiogenesis, and osteogenesis, and could be promising in wound healing and bone regeneration applications.

POLYMERS (2021)

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Review Cell Biology

Vascularization Strategies in Bone Tissue Engineering

Filip Simunovic et al.

Summary: Bone is a highly vascularized tissue, and the development, maturation, remodeling, and regeneration of bone depend on tight regulation of blood vessel supply. In bone tissue engineering, various vascularization strategies are being utilized, such as angiogenic growth factors, co-implantation of blood vessel forming cells, ex vivo microfabrication of blood vessels through bioprinting, and surgical methods for creating composite tissues that can be surgically transferred.

CELLS (2021)

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Review Engineering, Biomedical

Sterilization and disinfection methods for decellularized matrix materials: Review, consideration and proposal

Meihan Tao et al.

Summary: This review discusses the definitions of sterilization and disinfection, the effects on dECM, and various methods for sterilization and disinfection. It also proposes recommendations for selecting appropriate sterilization or disinfection methods and validating them.

BIOACTIVE MATERIALS (2021)

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Review Pharmacology & Pharmacy

Application of 3D Printing Technology in Bone Tissue Engineering: A Review

Yashan Feng et al.

Summary: The treatment of bone defects presents a significant challenge, requiring more effective biomaterials. 3D printing technology has emerged as a promising solution, allowing for the creation of complex bone scaffolds that closely mimic human bone structure. The combination of active substances with 3D printed scaffolds has shown great potential for personalized bone defect treatment and has led to the development of an emerging industry with excellent market prospects.

CURRENT DRUG DELIVERY (2021)

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Article Surgery

Partial Ear Reconstruction with a Prelaminated Induced Expanded Radial Artery Flap

Federico Flaherty et al.

Summary: A 76-year-old man underwent a novel partial ear reconstruction involving combined suprafascial tissue expansion, an alloplastic framework fabricated with porous polyethylene, and a radial artery free flap. The patient was satisfied with the outcome at 1-year follow-up.

PLASTIC AND RECONSTRUCTIVE SURGERY-GLOBAL OPEN (2021)

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Article Biochemistry & Molecular Biology

Osteogenic and antibacterial dual functions of a novel levofloxacin loaded mesoporous silica microspheres/nano-hydroxyapatite/polyurethane composite scaffold

Zhiping Kuang et al.

Summary: Lev/MSNs/n-HA/PU composite scaffold has been proven to possess dual functions of anti-infection and enhanced osteogenesis in vitro. The material promotes osteogenic differentiation of MSCs, proliferation and differentiation of MC3T3-E1 cells, as well as inhibits apoptosis. Additionally, Lev/MSNs/n-HA/PU exhibits clear in vitro antibacterial effects.

GENES & DISEASES (2021)

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Article Cell & Tissue Engineering

Pro-angiogenic and osteogenic composite scaffolds of fibrin, alginate and calcium phosphate for bone tissue engineering

Nupur Kohli et al.

Summary: This study aimed to develop new composite biomaterials with pro-angiogenic and osteogenic properties for bone tissue engineering applications. The materials were characterized as porous with evenly distributed deposits of CaP precursor phases, which facilitated cell adhesion, proliferation, migration, and differentiation down the osteogenic pathway. In addition, results from the CAM assay showed that the scaffolds were pro-angiogenic and biocompatible, highlighting their potential for further pre-clinical research prior to clinical translation.

JOURNAL OF TISSUE ENGINEERING (2021)

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Review Cell & Tissue Engineering

Bone defect reconstruction via endochondral ossification: A developmental engineering strategy

Rao Fu et al.

Summary: Traditional bone tissue engineering strategies face limitations in vascularization and bone regeneration, while engineering cartilaginous constructs mimicking embryonic processes offer a unique ability to promote bone regeneration. These developmentally engineered constructs can serve as transient biomimetic templates for facilitating bone regeneration in critical-sized defects.

JOURNAL OF TISSUE ENGINEERING (2021)

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Article Nanoscience & Nanotechnology

Three-Dimensional Melt-Electrowritten Polycaprolactone/Chitosan Scaffolds Enhance Mesenchymal Stem Cell Behavior

Minami Yoshida et al.

Summary: Melt electrowriting (MEW) is a promising technique for fabricating microfibrous scaffolds ideal for tissue engineering; the addition of chitosan to polycaprolactone (PCL) can enhance the bioactivity of the scaffold; experiments showed that chitosan-containing scaffolds significantly increase stem cell proliferation.

ACS APPLIED BIO MATERIALS (2021)

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Review Engineering, Biomedical

Contribution of Physical Methods in Decellularization of Animal Tissues

Mohsen Rabbani et al.

Summary: This review introduces and compares new physical methods for decellularization in tissue engineering, highlighting the potential benefits of applying physical methods over current chemical methods. Physical methods offer advantages in preserving ECM structure and essential substances, as well as providing easier optimization and control in decellularization protocols.

JOURNAL OF MEDICAL SIGNALS & SENSORS (2021)

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Article Dentistry, Oral Surgery & Medicine

Reconstruction of mandible using a computer-designed 3D-printed patient-specific titanium implant: a case report

Khaldoun Darwich et al.

Summary: The use of customized biomaterials in reconstructive surgery, such as 3D-printed titanium implants, has revolutionized the field and provided excellent postoperative aesthetic and functional results in mandibular reconstruction.

ORAL AND MAXILLOFACIAL SURGERY-HEIDELBERG (2021)

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Article Dentistry, Oral Surgery & Medicine

Do osteoconductive bone substitutes result in similar bone regeneration for maxillary sinus augmentation when compared to osteogenic and osteoinductive bone grafts? A systematic review and frequentist network meta-analysis

E. A. Al-Moraissi et al.

INTERNATIONAL JOURNAL OF ORAL AND MAXILLOFACIAL SURGERY (2020)

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Article Dentistry, Oral Surgery & Medicine

Fracture of Standard Titanium Mandibular Reconstruction Plates and Preliminary Study of Three-Dimensional Printed Reconstruction Plates

Akram Abdo Almansoori et al.

JOURNAL OF ORAL AND MAXILLOFACIAL SURGERY (2020)

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Review Medical Laboratory Technology

Key components of engineering vascularized 3-dimensional bioprinted bone constructs

Fahimeh Shahabipour et al.

TRANSLATIONAL RESEARCH (2020)

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Article Instruments & Instrumentation

A collagen-based hydrogel containing tacrolimus for bone tissue engineering

Mir Hamed Nabavi et al.

DRUG DELIVERY AND TRANSLATIONAL RESEARCH (2020)

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The application of hyaluronic acid in bone regeneration

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Ishita Matai et al.

BIOMATERIALS (2020)

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Article Materials Science, Biomaterials

Nanofibrous poly(vinyl alcohol)/chitosan contained carbonated hydroxyapatite nanoparticles scaffold for bone tissue engineering

I. Komang Januariyasa et al.

MATERIALS SCIENCE AND ENGINEERING C-MATERIALS FOR BIOLOGICAL APPLICATIONS (2020)

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Effect of the nano/microscale structure of biomaterial scaffolds on bone regeneration

Lisha Zhu et al.

INTERNATIONAL JOURNAL OF ORAL SCIENCE (2020)

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Reconstruction of Large Skeletal Defects: Current Clinical Therapeutic Strategies and Future Directions Using 3D Printing

Luciano Vidal et al.

FRONTIERS IN BIOENGINEERING AND BIOTECHNOLOGY (2020)

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Article Biotechnology & Applied Microbiology

Convergence of Scaffold-Guided Bone Reconstruction and Surgical Vascularization Strategies-A Quest for Regenerative Matching Axial Vascularization

David S. Sparks et al.

FRONTIERS IN BIOENGINEERING AND BIOTECHNOLOGY (2020)

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Article Cell Biology

An engineered cell-laden adhesive hydrogel promotes craniofacial bone tissue regeneration in rats

Mohammad Mahdi Hasani-Sadrabadi et al.

SCIENCE TRANSLATIONAL MEDICINE (2020)

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Article Engineering, Biomedical

Mechanical properties of diamond lattice Ti-6Al-4V structures produced by laser powder bed fusion: On the effect of the load direction

Antonio Cutolo et al.

JOURNAL OF THE MECHANICAL BEHAVIOR OF BIOMEDICAL MATERIALS (2020)

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Porous zinc scaffolds for bone tissue engineering applications: A novel additive manufacturing and casting approach

Irsalan Cockerill et al.

MATERIALS SCIENCE & ENGINEERING C-MATERIALS FOR BIOLOGICAL APPLICATIONS (2020)

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Review Materials Science, Biomaterials

Recent trends in the application of widely used natural and synthetic polymer nanocomposites in bone tissue regeneration

Angshuman Bharadwaz et al.

MATERIALS SCIENCE AND ENGINEERING C-MATERIALS FOR BIOLOGICAL APPLICATIONS (2020)

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Recent Advances in Mechanically Loaded Human Mesenchymal Stem Cells for Bone Tissue Engineering

Kar Wey Yong et al.

INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES (2020)

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Challenges on optimization of 3D-printed bone scaffolds

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BIOMEDICAL ENGINEERING ONLINE (2020)

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An Ovine Model ofIn VivoBioreactor-Based Bone Generation

Emma Watson et al.

TISSUE ENGINEERING PART C-METHODS (2020)

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Article Multidisciplinary Sciences

In situ bone regeneration of large cranial defects using synthetic ceramic implants with a tailored composition and design

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PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2020)

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Comprehensive Survey on Nanobiomaterials for Bone Tissue Engineering Applications

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Article Biochemistry & Molecular Biology

Scalable Microgravity Simulator Used for Long-Term Musculoskeletal Cells and Tissue Engineering

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Role of Hydrogels in Bone Tissue Engineering: How Properties Shape Regeneration

Yanting Wu et al.

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Sustained Calcium(II)-Release to Impart Bioactivity in Hybrid Glass Scaffolds for Bone Tissue Engineering

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Synthesis and characterization of PLGA/HAP scaffolds with DNA-functionalised calcium phosphate nanoparticles for bone tissue engineering

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Bifocal Compression-Distraction for Combined Bone and Soft-Tissue Defects in Post-traumatic Tibial Nonunion

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Mineralization in micropores of calcium phosphate scaffolds

Laurence E. Rustom et al.

ACTA BIOMATERIALIA (2019)

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Editorial Material Cardiac & Cardiovascular Systems

One-Step Laryngotracheal Reconstruction With Prefabricated Corticoperiosteal Flap

Jacek Banaszewski et al.

ANNALS OF THORACIC SURGERY (2019)

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Article Nanoscience & Nanotechnology

Enhanced bone regeneration of the silk fibroin electrospun scaffolds through the modification of the graphene oxide functionalized by BMP-2 peptide

Jiannan Wu et al.

INTERNATIONAL JOURNAL OF NANOMEDICINE (2019)

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Article Orthopedics

Cellular biology of fracture healing

Chelsea S. Bahney et al.

JOURNAL OF ORTHOPAEDIC RESEARCH (2019)

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Review Endocrinology & Metabolism

Pulsed electromagnetic fields: promising treatment for osteoporosis

T. Wang et al.

OSTEOPOROSIS INTERNATIONAL (2019)

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Review Engineering, Biomedical

Upgrading prevascularization in tissue engineering: A review of strategies for promoting highly organized microvascular network formation

Dhavan Sharma et al.

ACTA BIOMATERIALIA (2019)

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Article Dentistry, Oral Surgery & Medicine

A small number of residual teeth after the mandibular resection of oral cancer is associated with titanium reconstruction plate exposure

Hiromi Hirohata et al.

CLINICAL AND EXPERIMENTAL DENTAL RESEARCH (2019)

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Review Engineering, Biomedical

Additive manufacturing of bone scaffolds

Youwen Yang et al.

INTERNATIONAL JOURNAL OF BIOPRINTING (2019)

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Review Pharmacology & Pharmacy

Platelet-Rich Plasma and Platelet-Rich Fibrin in Periodontal Regeneration: A Review

Sunil Paramel Mohan et al.

JOURNAL OF PHARMACY AND BIOALLIED SCIENCES (2019)

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Article Materials Science, Biomaterials

Bone remodeling effect of a chitosan and calcium phosphate-based composite

Lilja Kjalarsdottir et al.

REGENERATIVE BIOMATERIALS (2019)

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Article Cell & Tissue Engineering

BIOFABRICATION OF MULTISCALE BONE EXTRACELLULAR MATRIX SCAFFOLDS FOR BONE TISSUE ENGINEERING

F. E. Freeman et al.

EUROPEAN CELLS & MATERIALS (2019)

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Article Surgery

A Novel Method of Neo-osseous Flap Prefabrication: Induction of Free Calvarial Periosteum with Bioactive Glass

Ali Aliyev et al.

JOURNAL OF RECONSTRUCTIVE MICROSURGERY (2018)

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Article Biotechnology & Applied Microbiology

Graphene based scaffolds on bone tissue engineering

Nasrin Shadjou et al.

BIOENGINEERED (2018)

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Article Cell & Tissue Engineering

Vascularization of Natural and Synthetic Bone Scaffolds

Xi Liu et al.

CELL TRANSPLANTATION (2018)

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Review Biochemistry & Molecular Biology

Natural and synthetic polymersibioceramicsibioactive compounds-mediated cell signalling in bone tissue engineering

S. Harsha Rao et al.

INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES (2018)

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Review Cell Biology

Bone tissue engineering: Adult stem cells in combination with electrospun nanofibrous scaffolds

Sadegh L. Moradi et al.

JOURNAL OF CELLULAR PHYSIOLOGY (2018)

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Review Dentistry, Oral Surgery & Medicine

Vascularization in Craniofacial Bone Tissue Engineering

T. Tian et al.

JOURNAL OF DENTAL RESEARCH (2018)

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Review Cell & Tissue Engineering

Large Animal Models of an In Vivo Bioreactor for Engineering Vascularized Bone

Banu Akar et al.

TISSUE ENGINEERING PART B-REVIEWS (2018)

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Review Engineering, Biomedical

Current state of fabrication technologies and materials for bone tissue engineering

Abiy Wubneh et al.

ACTA BIOMATERIALIA (2018)

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Article Surgery

Chitosan as a Bone Scaffold Biomaterial

Steven D. Kozusko et al.

JOURNAL OF CRANIOFACIAL SURGERY (2018)

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Article Surgery

Custom CAD/CAM implants for complex craniofacial reconstruction in children: Our experience based on 136 cases

Phuong D. Nguyen et al.

JOURNAL OF PLASTIC RECONSTRUCTIVE AND AESTHETIC SURGERY (2018)

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Review Materials Science, Biomaterials

Recent Progress of Fabrication of Cell Scaffold by Electrospinning Technique for Articular Cartilage Tissue Engineering

Yingge Zhou et al.

INTERNATIONAL JOURNAL OF BIOMATERIALS (2018)

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Review Biology

The regenerative effects of electromagnetic field on spinal cord injury

Christina L. Ross et al.

ELECTROMAGNETIC BIOLOGY AND MEDICINE (2017)

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Review Dentistry, Oral Surgery & Medicine

Guided bone regeneration: materials and biological mechanisms revisited

Ibrahim Elgali et al.

EUROPEAN JOURNAL OF ORAL SCIENCES (2017)

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Review Nanoscience & Nanotechnology

A review of fibrin and fibrin composites for bone tissue engineering

Alireza Noori et al.

INTERNATIONAL JOURNAL OF NANOMEDICINE (2017)

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Article Orthopedics

Critical-Sized Bone Defects: Sequence and Planning

Paul Toogood et al.

JOURNAL OF ORTHOPAEDIC TRAUMA (2017)

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Article Surgery

Prefabrication of Vascularized Allogenic Bone Graft in a Rat by Implanting a Flow-Through Vascular Pedicle and Basic Fibroblast Growth Factor Containing Hydroxyapatite/Collagen Composite

Konosuke Yamaguchi et al.

JOURNAL OF RECONSTRUCTIVE MICROSURGERY (2017)

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Review Materials Science, Biomaterials

Scaffolds for Bone Tissue Engineering: State of the art and new perspectives

Livia Roseti et al.

MATERIALS SCIENCE AND ENGINEERING C-MATERIALS FOR BIOLOGICAL APPLICATIONS (2017)

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Article Multidisciplinary Sciences

Prefabrication of a functional bone graft with a pedicled periosteal flap as an in vivo bioreactor

Ru-Lin Huang et al.

SCIENTIFIC REPORTS (2017)

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Article Engineering, Biomedical

Biomimetic Materials and Fabrication Approaches for Bone Tissue Engineering

Hwan D. Kim et al.

ADVANCED HEALTHCARE MATERIALS (2017)

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Article Engineering, Biomedical

Calcium Phosphate-Collagen Scaffold with Aligned Pore Channels for Enhanced Osteochondral Regeneration

Yun-Jeong Seong et al.

ADVANCED HEALTHCARE MATERIALS (2017)

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Article Medicine, Research & Experimental

Biologic Scaffolds

Alessandra Costa et al.

COLD SPRING HARBOR PERSPECTIVES IN MEDICINE (2017)

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Article Dentistry, Oral Surgery & Medicine

Free flap reconstruction for patients aged 85 years and over with head and neck cancer: clinical considerations for comprehensive care

X. F. Chen et al.

BRITISH JOURNAL OF ORAL & MAXILLOFACIAL SURGERY (2017)

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Review Engineering, Biomedical

Silk scaffolds in bone tissue engineering: An overview

Promita Bhattacharjee et al.

ACTA BIOMATERIALIA (2017)

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Review Peripheral Vascular Disease

The role of vasculature in bone development, regeneration and proper systemic functioning

Joanna Filipowska et al.

ANGIOGENESIS (2017)

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Article Cell & Tissue Engineering

RECENT ADVANCES IN HYDROGELS FOR CARTILAGE TISSUE ENGINEERING

S. L. Vega et al.

EUROPEAN CELLS & MATERIALS (2017)

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Review Biotechnology & Applied Microbiology

Platelet-rich plasma for bone healing and regeneration

Ahmad Oryan et al.

EXPERT OPINION ON BIOLOGICAL THERAPY (2016)

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Article Engineering, Biomedical

Hybrid use of combined and sequential delivery of growth factors and ultrasound stimulation in porous multilayer composite scaffolds to promote both vascularization and bone formation in bone tissue engineering

Haoran Yan et al.

JOURNAL OF BIOMEDICAL MATERIALS RESEARCH PART A (2016)

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Article Engineering, Biomedical

Reconstruction of large mandibular defects using autologous tissues generated from in vivo bioreactors

Alexander M. Tatara et al.

ACTA BIOMATERIALIA (2016)

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Review Engineering, Biomedical

Biofabrication of bone tissue: approaches, challenges and translation for bone regeneration

Daniel Tang et al.

BIOMATERIALS (2016)

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Article Engineering, Biomedical

Direct 3D bioprinting of perfusable vascular constructs using a blend bioink

Weitao Jia et al.

BIOMATERIALS (2016)

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Article Engineering, Biomedical

Tissue engineered pre-vascularized buccal mucosa equivalents utilizing a primary triculture of epithelial cells, endothelial cells and fibroblasts

M. Heller et al.

BIOMATERIALS (2016)

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Review Engineering, Biomedical

3D-printing techniques in a medical setting: a systematic literature review

Philip Tack et al.

BIOMEDICAL ENGINEERING ONLINE (2016)

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Review Biotechnology & Applied Microbiology

Prevascularization in tissue engineering: Current concepts and future directions

Matthias W. Laschke et al.

BIOTECHNOLOGY ADVANCES (2016)

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Review Biochemistry & Molecular Biology

Biomimetic composite scaffolds containing bioceramics and collagen/gelatin for bone tissue engineering - A mini review

Shruthy Kuttappan et al.

INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES (2016)

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Article Dentistry, Oral Surgery & Medicine

Facial bone reconstruction with prefabricated vascularized calvarium flaps in children and young adults: Advantages and long-term results

Eva Meia Ruegg et al.

JOURNAL OF CRANIO-MAXILLOFACIAL SURGERY (2016)

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Article Cell Biology

Cytokine, chemokine, and growth factor profile of platelet-rich plasma

F. Mussano et al.

PLATELETS (2016)

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Review Cell & Tissue Engineering

Stem Cells in Bone Regeneration

Graham G. Walmsley et al.

STEM CELL REVIEWS AND REPORTS (2016)

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Article Cell & Tissue Engineering

Prefabrication of axially vascularized bone by combining β-tricalciumphosphate, arteriovenous loop, and cell sheet technique

Dongyang Ma et al.

TISSUE ENGINEERING AND REGENERATIVE MEDICINE (2016)

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Article Cell & Tissue Engineering

Treatment of Large Bone Defects with a Vascularized Periosteal Flap in Combination with Biodegradable Scaffold Seeded with Bone Marrow-Derived Mononuclear Cells: An Experimental Study in Rats

Christoph Nau et al.

TISSUE ENGINEERING PART A (2016)

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Review Cell & Tissue Engineering

A Review of the Clinical Side Effects of Bone Morphogenetic Protein-2

Aaron W. James et al.

TISSUE ENGINEERING PART B-REVIEWS (2016)

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Article Cell & Tissue Engineering

Man as a Living Bioreactor: Prefabrication of a Custom Vascularized Bone Graft in the Gastrocolic Omentum

Joerg Wiltfang et al.

TISSUE ENGINEERING PART C-METHODS (2016)

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Review Cell & Tissue Engineering

Stem Cells in Bone Regeneration

Graham G. Walmsley et al.

STEM CELL REVIEWS AND REPORTS (2016)

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Article Cell & Tissue Engineering

Prefabrication of axially vascularized bone by combining β-tricalciumphosphate, arteriovenous loop, and cell sheet technique

Dongyang Ma et al.

TISSUE ENGINEERING AND REGENERATIVE MEDICINE (2016)

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Article Multidisciplinary Sciences

The Arteriovenous (AV) Loop in a Small Animal Model to Study Angiogenesis and Vascularized Tissue Engineering

Annika Weigand et al.

JOVE-JOURNAL OF VISUALIZED EXPERIMENTS (2016)

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Review Medicine, General & Internal

Bone Graft Prefabrication Following the In Vivo Bioreactor Principle

Ru-Lin Huang et al.

EBIOMEDICINE (2016)

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Review Cell & Tissue Engineering

Sterilization techniques for biodegradable scaffolds in tissue engineering applications

Zheng Dai et al.

JOURNAL OF TISSUE ENGINEERING (2016)

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Review Materials Science, Biomaterials

Recent advances of biomaterials in biotherapy

Ling Li et al.

REGENERATIVE BIOMATERIALS (2016)

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Article Peripheral Vascular Disease

Large-scale time series microscopy of neovessel growth during angiogenesis

Urs Utzinger et al.

ANGIOGENESIS (2015)

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Article Cell & Tissue Engineering

The Dose-Effect Relationship Between the Seeding Quantity of Human Marrow Mesenchymal Stem Cells and In Vivo Tissue-Engineered Bone Yield

Huanhuan Wu et al.

CELL TRANSPLANTATION (2015)

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Article Dentistry, Oral Surgery & Medicine

Heterotopic bone formation in the musculus latissimus dorsi of sheep using β-tricalcium phosphate scaffolds: evaluation of an extended prefabrication time on bone formation and matrix degeneration

S. Spalthoff et al.

INTERNATIONAL JOURNAL OF ORAL AND MAXILLOFACIAL SURGERY (2015)

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Review Nanoscience & Nanotechnology

Metallic Nanomaterials for Bone Tissue Engineering

S. Dhivya et al.

JOURNAL OF BIOMEDICAL NANOTECHNOLOGY (2015)

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Article Surgery

Complications in 54 Frontofacial Distraction Procedures in Patients With Syndromic Craniosynostosis

Jesse A. Goldstein et al.

JOURNAL OF CRANIOFACIAL SURGERY (2015)

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Article Surgery

Comparison of Bone Prefabrication with Vascularized Periosteal Flaps, Hydroxyapatite, and Bioactive Glass in Rats

Burak Ersoy et al.

JOURNAL OF RECONSTRUCTIVE MICROSURGERY (2015)

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Article Surgery

Repair of a Critical Porcine Tibial Defect by Means of Allograft Revitalization

Christopher M. Runyan et al.

PLASTIC AND RECONSTRUCTIVE SURGERY (2015)

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Article Multidisciplinary Sciences

The Value of SPECT/CT in Monitoring Prefabricated Tissue-Engineered Bone and Orthotopic rhBMP-2 Implants for Mandibular Reconstruction

Miao Zhou et al.

PLOS ONE (2015)

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Article Cell & Tissue Engineering

Combination of BMP2 and MSCs Significantly Increases Bone Formation in the Rat Arterio-Venous Loop Model

Gregor Buehrer et al.

TISSUE ENGINEERING PART A (2015)

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Article Biotechnology & Applied Microbiology

Collagen/Beta-Tricalcium Phosphate Based Synthetic Bone Grafts via Dehydrothermal Processing

Burcu Sarikaya et al.

BIOMED RESEARCH INTERNATIONAL (2015)

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Review Biotechnology & Applied Microbiology

Chitosan and Its Potential Use as a Scaffold for Tissue Engineering in Regenerative Medicine

Martin Rodriguez-Vazquez et al.

BIOMED RESEARCH INTERNATIONAL (2015)

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Article Dentistry, Oral Surgery & Medicine

Enhanced bone healing by improved fibrin-clot formation via fibrinogen adsorption on biphasic calcium phosphate granules

Beom-Su Kim et al.

CLINICAL ORAL IMPLANTS RESEARCH (2015)

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Review Cell & Tissue Engineering

Advances in tissue engineering through stem cell-based co-culture

Nikolaos K. Paschos et al.

JOURNAL OF TISSUE ENGINEERING AND REGENERATIVE MEDICINE (2015)

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Article Multidisciplinary Sciences

Osteogenic Differentiation of Human Mesenchymal Stem Cells in 3-D Zr-Si Organic-Inorganic Scaffolds Produced by Two-Photon Polymerization Technique

Anastasia Koroleva et al.

PLOS ONE (2015)

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Article Surgery

Prelamination of the Anterolateral Thigh Flap With a Fibula Graft to Successfully Reconstruct a Mandibular Defect

Parviz Lionel Sadigh et al.

PLASTIC AND RECONSTRUCTIVE SURGERY-GLOBAL OPEN (2015)

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Article Critical Care Medicine

Neutralization of osteopontin attenuates neutrophil migration in sepsis-induced acute lung injury

Yohei Hirano et al.

CRITICAL CARE (2015)

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Article Engineering, Biomedical

Rabbit Tibial Periosteum and Saphenous Arteriovenous Vascular Bundle as an In Vivo Bioreactor to Construct Vascularized Tissue- Engineered Bone: A Feasibility Study

Dong Han et al.

ARTIFICIAL ORGANS (2014)

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Article Engineering, Biomedical

Efficacy of prevascularization for segmental bone defect repair using β-tricalcium phosphate scaffold in rhesus monkey

Hongbin Fan et al.

BIOMATERIALS (2014)

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Article Cell Biology

Wrapped omentum with periosteum concurrent with adipose derived adult stem cells for bone tissue engineering in dog model

Amin Bigham Sadegh et al.

CELL AND TISSUE BANKING (2014)

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Article Dentistry, Oral Surgery & Medicine

Enhancing mandibular bone regeneration and perfusion via axial vascularization of scaffolds

Ahmad Mahmoud Eweida et al.

CLINICAL ORAL INVESTIGATIONS (2014)

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Article Cell Biology

Successful human long-term application of in situ bone tissue engineering

Raymund E. Horch et al.

JOURNAL OF CELLULAR AND MOLECULAR MEDICINE (2014)

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Review Surgery

Prefabrication and Prelamination Strategies for the Reconstruction of Complex Defects of Trachea and Larynx

J. J. Vranckx et al.

JOURNAL OF RECONSTRUCTIVE MICROSURGERY (2014)

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Article Surgery

FREE TISSUE TRANSFERS IN HEAD AND NECK RECONSTRUCTION: COMPLICATIONS, OUTCOMES AND STRATEGIES FOR MANAGEMENT OF FLAP FAILURE: ANALYSIS OF 2019 FLAPS IN SINGLE INSTITUTE

Cheng-Chun Wu et al.

MICROSURGERY (2014)

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Review Cell & Tissue Engineering

Hope versus hype: what can additive manufacturing realistically offer trauma and orthopedic surgery?

David M. R. Gibbs et al.

REGENERATIVE MEDICINE (2014)

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Review Clinical Neurology

Complications with the use of bone morphogenetic protein 2 (BMP-2) in spine surgery

Chadi A. Tannoury et al.

SPINE JOURNAL (2014)

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Article Cell & Tissue Engineering

Tissue Engineering of a Vascularized Bone Graft of Critical Size with an Osteogenic and Angiogenic Factor-Based In Vivo Bioreactor

Yanming Liu et al.

TISSUE ENGINEERING PART A (2014)

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Review Biochemistry & Molecular Biology

Bone Morphogenetic Protein (BMP) signaling in development and human diseases

Richard N. Wang et al.

GENES & DISEASES (2014)

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Review Biochemical Research Methods

Bioreactors in tissue engineering - principles, applications and commercial constraints

Jan Hansmann et al.

BIOTECHNOLOGY JOURNAL (2013)

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Article Orthopedics

Development of a new pre-vascularized tissue-engineered construct using pre-differentiated rADSCs, arteriovenous vascular bundle and porous nano-hydroxyapatide-polyamide 66 scaffold

Pei Yang et al.

BMC MUSCULOSKELETAL DISORDERS (2013)

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Review Immunology

Localized delivery of growth factors for angiogenesis and bone formation in tissue engineering

Yan Bai et al.

INTERNATIONAL IMMUNOPHARMACOLOGY (2013)

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Review Orthopedics

Role of mesenchymal stem cells in bone regeneration and fracture repair: a review

Xin Wang et al.

INTERNATIONAL ORTHOPAEDICS (2013)

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Article Surgery

Prefabrication as a Term in Flap Surgery: Do We Need a Broader Definition?

Xian Wei et al.

JOURNAL OF RECONSTRUCTIVE MICROSURGERY (2013)

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Article Surgery

Prefabrication of Vascularized Bone Allograft in a Recipient Rat Using a Flow-through Vascular Pedicle, Bone Morphogenetic Protein, and Bisphosphonate

Osamu Nakamura et al.

JOURNAL OF RECONSTRUCTIVE MICROSURGERY (2013)

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Article Cell & Tissue Engineering

Engineering axially vascularized bone in the sheep arteriovenous-loop model

Anja M. Boos et al.

JOURNAL OF TISSUE ENGINEERING AND REGENERATIVE MEDICINE (2013)

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Article Cell & Tissue Engineering

Microwave-sintered 3D printed tricalcium phosphate scaffolds for bone tissue engineering

Solaiman Tarafder et al.

JOURNAL OF TISSUE ENGINEERING AND REGENERATIVE MEDICINE (2013)

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Review Engineering, Biomedical

Engineering the Regenerative Microenvironment with Biomaterials

Jeffrey J. Rice et al.

ADVANCED HEALTHCARE MATERIALS (2013)

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Review Engineering, Biomedical

Collagen for bone tissue regeneration

Ana Marina Ferreira et al.

ACTA BIOMATERIALIA (2012)

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Review Pharmacology & Pharmacy

Strategies for controlled delivery of growth factors and cells for bone regeneration

Tiffany N. Vo et al.

ADVANCED DRUG DELIVERY REVIEWS (2012)

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Article Pharmacology & Pharmacy

Scaffold: A Novel Carrier for Cell and Drug Delivery

Tarun Garg et al.

CRITICAL REVIEWS IN THERAPEUTIC DRUG CARRIER SYSTEMS (2012)

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Review Biochemistry & Molecular Biology

Lysine post-translational modifications of collagen

Mitsuo Yamauchi et al.

LYSINE-BASED POST-TRANSLATIONAL MODIFICATION OF PROTEINS (2012)

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Review Cell Biology

Tissue engineering and regenerative medicine -where do we stand?

Raymund E. Horch et al.

JOURNAL OF CELLULAR AND MOLECULAR MEDICINE (2012)

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Article Surgery

What Is the Price to Pay for a Free Fibula Flap? A Systematic Review of Donor-Site Morbidity following Free Fibula Flap Surgery

Xiao Feng Ling et al.

PLASTIC AND RECONSTRUCTIVE SURGERY (2012)

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Article Surgery

Soft-Tissue Reconstruction of Open Fractures of the Lower Limb: Muscle versus Fasciocutaneous Flaps

James K. -K. Chan et al.

PLASTIC AND RECONSTRUCTIVE SURGERY (2012)

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Review Biotechnology & Applied Microbiology

Recent advances in bone tissue engineering scaffolds

Susmita Bose et al.

TRENDS IN BIOTECHNOLOGY (2012)

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Article Oncology

The use of prefabrication technique in microvascular reconstructive surgery

Lukasz Krakowczyk et al.

WSPOLCZESNA ONKOLOGIA-CONTEMPORARY ONCOLOGY (2012)

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Article Dentistry, Oral Surgery & Medicine

Prefabrication of vascularized bone grafts using a combination of bone marrow mesenchymal stem cells and vascular bundles with β-tricalcium phosphate ceramics

Zhiwei Dong et al.

ORAL SURGERY ORAL MEDICINE ORAL PATHOLOGY ORAL RADIOLOGY (2012)

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Review Cell & Tissue Engineering

Concise Review: The Periosteum: Tapping into a Reservoir of Clinically Useful Progenitor Cells

Hana Chang et al.

STEM CELLS TRANSLATIONAL MEDICINE (2012)

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Review Engineering, Biomedical

Bioactive and Biodegradable Nanocomposites and Hybrid Biomaterials for Bone Regeneration

Bedilu A. Allo et al.

JOURNAL OF FUNCTIONAL BIOMATERIALS (2012)

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Article Chemistry, Multidisciplinary

Clay Gels For the Delivery of Regenerative Microenvironments

Jonathan I. Dawson et al.

ADVANCED MATERIALS (2011)

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Review Medicine, General & Internal

Bone regeneration: current concepts and future directions

Rozalia Dimitriou et al.

BMC MEDICINE (2011)

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Article Otorhinolaryngology

The temporoparietal fascia flap: a versatile tool in head and neck reconstruction

Yves Jaquet et al.

CURRENT OPINION IN OTOLARYNGOLOGY & HEAD AND NECK SURGERY (2011)

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Article Dentistry, Oral Surgery & Medicine

Morbidity Associated With Iliac Crest Harvesting in the Treatment of Maxillary and Mandibular Atrophies: A 10-Year Analysis

Antonio Barone et al.

JOURNAL OF ORAL AND MAXILLOFACIAL SURGERY (2011)

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Article Materials Science, Multidisciplinary

Effect of TiO2 morphology on in vitro bioactivity of polycaprolactone/TiO2 nanocomposites

E. Tamjid et al.

MATERIALS LETTERS (2011)

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Article Materials Science, Multidisciplinary

Biomaterials & scaffolds for tissue engineering

Fergal J. O'Brien

MATERIALS TODAY (2011)

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Article Cell & Tissue Engineering

In vitro Biomimetic Construction of Hydroxyapatite-Porcine Acellular Dermal Matrix Composite Scaffold for MC3T3-E1 Preosteoblast Culture

Hongshi Zhao et al.

TISSUE ENGINEERING PART A (2011)

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Article Cell Biology

SDF-1/CXCR4 axis modulates bone marrow mesenchymal stem cell apoptosis, migration and cytokine secretion

Xiaolei Liu et al.

PROTEIN & CELL (2011)

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Article Surgery

Prefabrication of Tissue Engineered Bone Grafts An Experimental Study

Takahisa Okuda et al.

ANNALS OF PLASTIC SURGERY (2010)

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Article Dentistry, Oral Surgery & Medicine

Prefabrication of vascularized bioartificial bone grafts in vivo for segmental mandibular reconstruction: experimental pilot study in sheep and first clinical application

H. Kokemueller et al.

INTERNATIONAL JOURNAL OF ORAL AND MAXILLOFACIAL SURGERY (2010)

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Article Surgery

Angiogenesis and osteogenesis of non-vascularised autogenous bone graft with arterial pedicle implantation

Yao Yao et al.

JOURNAL OF PLASTIC RECONSTRUCTIVE AND AESTHETIC SURGERY (2010)

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Article Cell & Tissue Engineering

Axial vascularization of a large volume calcium phosphate ceramic bone substitute in the sheep AV loop model

Justus P. Beier et al.

JOURNAL OF TISSUE ENGINEERING AND REGENERATIVE MEDICINE (2010)

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Article Multidisciplinary Sciences

Novel synthesis strategies for natural polymer and composite biomaterials as potential scaffolds for tissue engineering

Hsu-Feng Ko et al.

PHILOSOPHICAL TRANSACTIONS OF THE ROYAL SOCIETY A-MATHEMATICAL PHYSICAL AND ENGINEERING SCIENCES (2010)

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Article Cell & Tissue Engineering

The Effect of Simulated Microgravity on Human Mesenchymal Stem Cells Cultured in an Osteogenic Differentiation System: A Bioinformatics Study

Dima Sheyn et al.

TISSUE ENGINEERING PART A (2010)

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Article Otorhinolaryngology

PREFABRICATED BONY RADIAL FOREARM FLAP FOR SECONDARY MANDIBLE RECONSTRUCTION AFTER RADIOCHEMOTHERAPY

Henry Leonhardt et al.

HEAD AND NECK-JOURNAL FOR THE SCIENCES AND SPECIALTIES OF THE HEAD AND NECK (2009)

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Article Dentistry, Oral Surgery & Medicine

Novel maxillary reconstruction with ectopic bone formation by GMP adipose stem cells

K. Mesimaki et al.

INTERNATIONAL JOURNAL OF ORAL AND MAXILLOFACIAL SURGERY (2009)

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Article Endocrinology & Metabolism

ECM Compliance Regulates Osteogenesis by Influencing MAPK Signaling Downstream of RhoA and ROCK

Chirag B. Khatiwala et al.

JOURNAL OF BONE AND MINERAL RESEARCH (2009)

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Review Cell Biology

Mesenchymal stem cell-based therapy: a new paradigm in regenerative medicine

Neeraj Kumar Satija et al.

JOURNAL OF CELLULAR AND MOLECULAR MEDICINE (2009)

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Article Orthopedics

Rotating Three-Dimensional Dynamic Culture of Adult Human Bone Marrow-Derived Cells for Tissue Engineering of Hyaline Cartilage

Shinsuke Sakai et al.

JOURNAL OF ORTHOPAEDIC RESEARCH (2009)

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Article Cell & Tissue Engineering

Tissue Formation and Vascularization in Anatomically Shaped Human Joint Condyle Ectopically in Vivo

Chang H. Lee et al.

TISSUE ENGINEERING PART A (2009)

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Article Engineering, Biomedical

The biodegradability of electrospun Dextran/PLGA scaffold in a fibroblast/macrophage co-culture

Hui Pan et al.

BIOMATERIALS (2008)

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Article Biochemistry & Molecular Biology

Collagen scaffolds for tissue engineering

Julie Glowacki et al.

BIOPOLYMERS (2008)

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Article Developmental Biology

Osteogenic properties of human myogenic progenitor cells

Naohiro Hashimoto et al.

MECHANISMS OF DEVELOPMENT (2008)

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Article Cell & Tissue Engineering

Concise review: Adult multipotent stromal cells and cancer: Risk or benefit?

Gwendal Lazennec et al.

STEM CELLS (2008)

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Article Biology

Pulsed electromagnetic fields affect osteoblast proliferation and differentiation in bone tissue engineering

Ming-Tzu Tsai et al.

BIOELECTROMAGNETICS (2007)

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Review Engineering, Biomedical

A tissue engineering approach to bone repair in large animal models and in clinical practice

Ranieri Cancedda et al.

BIOMATERIALS (2007)

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Article Surgery

Intrinsic axial vascularization of an Osteoconductive bone matrix by means of an arteriovenous vascular bundle

Elias Polykandriotis et al.

PLASTIC AND RECONSTRUCTIVE SURGERY (2007)

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Article Cell & Tissue Engineering

Stem cells associated with macroporous bioceramics for long bone repair: 6-to 7-year outcome of a pilot clinical study

Maurilio Marcacci et al.

TISSUE ENGINEERING (2007)

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Article Surgery

Comparison of guided bone formation from periosteum and muscle fascia

Eric M. Brey et al.

PLASTIC AND RECONSTRUCTIVE SURGERY (2007)

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Article Dentistry, Oral Surgery & Medicine

Preparation of prefabricated vascularized bone graft with neoangiogenesis by combination of autologous tissue and biodegradable materials

A. Hokugo et al.

INTERNATIONAL JOURNAL OF ORAL AND MAXILLOFACIAL SURGERY (2006)

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Article Cell & Tissue Engineering

Minimal criteria for defining multipotent mesenchymal stromal cells. The International Society for Cellular Therapy position statement

M. Dominici et al.

CYTOTHERAPY (2006)

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Article Cell & Tissue Engineering

Engineering of vascularized transplantable bone tissues:: Induction of axial vascularization in an osteoconductive matrix using an arteriovenous loop

Ulrich Kneser et al.

TISSUE ENGINEERING (2006)

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Article Surgery

Mandible Augmentation for Osseointegrated Implants Using Tissue Engineering Strategies

Ming-Huei Cheng et al.

PLASTIC AND RECONSTRUCTIVE SURGERY (2006)

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Article Cell & Tissue Engineering

A crosstalk between myeloma cells and marrow stromal cells stimulates production of DKK1 and interleukin-6: A potential role in the development of lytic bone disease and tumor progression in multiple myeloma

William G. Gunn et al.

STEM CELLS (2006)

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Article Dentistry, Oral Surgery & Medicine

Transformation of a prefabricated hydroxyapatite/osteogenic protein-1 implant into a vascularised pedicled bone flap in the human chest

M Heliotis et al.

INTERNATIONAL JOURNAL OF ORAL AND MAXILLOFACIAL SURGERY (2006)

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Article Multidisciplinary Sciences

In vitro generated extracellular matrix and fluid shear stress synergistically enhance 3D osteoblastic differentiation

N Datta et al.

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2006)

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Review Biotechnology & Applied Microbiology

Bioreactors for tissue engineering

Huang-Chi Chen et al.

BIOTECHNOLOGY LETTERS (2006)

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Article Engineering, Biomedical

Hydroxyapatite scaffolds for bone tissue engineering made by 3D printing

B Leukers et al.

JOURNAL OF MATERIALS SCIENCE-MATERIALS IN MEDICINE (2005)

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Article Multidisciplinary Sciences

In vivo engineering of organs:: The bone bioreactor

MM Stevens et al.

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2005)

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Article Orthopedics

Evolution of an in vivo bioreactor

GE Holt et al.

JOURNAL OF ORTHOPAEDIC RESEARCH (2005)

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Article Surgery

Bone flap prefabrication -: An experimental study in rabbits

H Top et al.

ANNALS OF PLASTIC SURGERY (2005)

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Review Engineering, Biomedical

Bone tissue engineering and spinal fusion: the potential of hybrid constructs by combining osteoprogenitor cells and scaffolds

MC Kruyt et al.

BIOMATERIALS (2004)

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Article Medicine, General & Internal

Growth and transplantation of a custom vascularised bone graft in a man

PH Warnke et al.

LANCET (2004)

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Article Cell & Tissue Engineering

Translational research for injectable tissue-engineered bone regeneration using mesenchymal stem cells and platelet-rich plasma: From basic research to clinical case study

Y Yamada et al.

CELL TRANSPLANTATION (2004)

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Review Surgery

Vascularisation of tissue-engineered grafts: the regulation of angiogenesis in reconstructive surgery and in disease states

OCS Cassell et al.

BRITISH JOURNAL OF PLASTIC SURGERY (2002)

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Article Medicine, General & Internal

Replacement of an avulsed phalanx with tissue-engineered bone.

CA Vacanti et al.

NEW ENGLAND JOURNAL OF MEDICINE (2001)

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Article Cell & Tissue Engineering

Formation of new tissue from an arteriovenous loop in the absence of added extracellular matrix

RW Mian et al.

TISSUE ENGINEERING (2000)

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Article Biochemistry & Molecular Biology

The in situ conformation and axial location of the intermolecular cross-linked non-helical telopeptides of type I collagen

JP Orgel et al.

STRUCTURE WITH FOLDING & DESIGN (2000)

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