期刊
POLYMERS
卷 14, 期 12, 页码 -出版社
MDPI
DOI: 10.3390/polym14122510
关键词
polymers; critical micelle concentration; micelles; drug delivery; imaging
资金
- Ministry of Trade, Industry Energy, Korea [20017903]
- National Research Foundation of Korea (NRF) - Ministry of Science and ICT [2022R1A5A7000765]
- Korea Evaluation Institute of Industrial Technology (KEIT) [20017903] Funding Source: Korea Institute of Science & Technology Information (KISTI), National Science & Technology Information Service (NTIS)
- National Research Foundation of Korea [2022R1A5A7000765] Funding Source: Korea Institute of Science & Technology Information (KISTI), National Science & Technology Information Service (NTIS)
This review discusses the self-assembly of amphiphilic polymers into micelles (polymeric nanoparticles) and their importance in bio-applications. Micelles, with their unique properties, size, shape, and biocompatibility, enhance drug loading and target release, making them a research focus in the field of biomedicine.
Self-assembly of amphiphilic polymers with hydrophilic and hydrophobic units results in micelles (polymeric nanoparticles), where polymer concentrations are above critical micelle concentrations (CMCs). Recently, micelles with metal nanoparticles (MNPs) have been utilized in many bio-applications because of their excellent biocompatibility, pharmacokinetics, adhesion to biosurfaces, targetability, and longevity. The size of the micelles is in the range of 10 to 100 nm, and different shapes of micelles have been developed for applications. Micelles have been focused recently on bio-applications because of their unique properties, size, shape, and biocompatibility, which enhance drug loading and target release in a controlled manner. This review focused on how CMC has been calculated using various techniques. Further, micelle importance is explained briefly, different types and shapes of micelles are discussed, and further extensions for the application of micelles are addressed. In the summary and outlook, points that need focus in future research on micelles are discussed. This will help researchers in the development of micelles for different applications.
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