期刊
PLOS PATHOGENS
卷 18, 期 8, 页码 -出版社
PUBLIC LIBRARY SCIENCE
DOI: 10.1371/journal.ppat.1010670
关键词
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资金
- CNRS
- INSERM
- DZNE
- Association pour la recherche sur la SLA
- Association Francaise contre les Myopathies (AFM), MyoNeurAlp Alliance
Neurodegenerative diseases are fatal neurological diseases that may be associated with viral infections, which can lead to neuroinflammation and disruption of neuronal protein quality control, affecting the formation and spread of diseases.
Neurodegenerative diseases (NDs) such as Alzheimer's and Parkinson's disease are fatal neurological diseases that can be of idiopathic, genetic, or even infectious origin, as in the case of transmissible spongiform encephalopathies. The etiological factors that lead to neurodegeneration remain unknown but likely involve a combination of aging, genetic risk factors, and environmental stressors. Accumulating evidence hints at an association of viruses with neurodegenerative disorders and suggests that virus-induced neuroinflammation and perturbation of neuronal protein quality control can be involved in the early steps of disease development. In this review, we focus on emerging evidence for a correlation between NDs and viral infection and discuss how viral manipulations of cellular processes can affect the formation and dissemination of disease-associated protein aggregates.
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