期刊
PLOS PATHOGENS
卷 18, 期 7, 页码 -出版社
PUBLIC LIBRARY SCIENCE
DOI: 10.1371/journal.ppat.1010608
关键词
-
资金
- Wellcome Trust Sir Henry Dale Fellowship [218550/Z/19/Z]
- University of Exeter [MR/N006364/2]
- Medical Research Council Centre for Medical Mycology
- Wellcome Trust [218550/Z/19/Z] Funding Source: Wellcome Trust
This article discusses the crucial role of macrophages and dendritic cells in the development of fungal allergic diseases, as well as their role in mediating allergic inflammation within the lung environment.
Fungi are abundant in the environment, causing our lungs to be constantly exposed to a diverse range of species. While the majority of these are cleared effectively in healthy individuals, constant exposure to spores (especially Aspergillus spp.) can lead to the development of allergic inflammation that underpins and worsen diseases such as asthma. Despite this, the precise mechanisms that underpin the development of fungal allergic disease are poorly understood. Innate immune cells, such as macrophages (M phi s) and dendritic cells (DCs), have been shown to be critical for mediating allergic inflammation to a range of different allergens. This review will focus on the crucial role of M phi and DCs in mediating antifungal immunity, evaluating how these immune cells mediate allergic inflammation within the context of the lung environment. Ultimately, we aim to highlight important future research questions that will lead to novel therapeutic strategies for fungal allergic diseases.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据