4.6 Article

2-deoxyglucose transiently inhibits yeast AMPK signaling and triggers glucose transporter endocytosis, potentiating the drug toxicity

相关参考文献

注意:仅列出部分参考文献,下载原文获取全部文献信息。
Review Cell Biology

The α-arrestin family of ubiquitin ligase adaptors links metabolism with selective endocytosis

Jennifer Kahlhofer et al.

Summary: Regulating the endocytosis of nutrient transporters is crucial for maintaining homoeostasis and cell growth, with α-arrestin proteins mediating this process in yeast. While the function and regulation of yeast ARTs are well-studied, the role of human alpha-arrestins remains under-characterized.

BIOLOGY OF THE CELL (2021)

Review Cell Biology

Membrane Protein Quality Control Mechanisms in the Endo-Lysosome System

Richa Sardana et al.

Summary: Protein quality control machineries are essential for identifying and removing mistargeted, misfolded, and aberrant proteins, but the complexity of the proteome makes this task challenging. Genetic and proteomic approaches are beginning to reveal how these machineries recognize targets and regulate their activity. This review provides an overview of E3 ubiquitin ligases and associated machinery involved in protein quality control, aiming to guide future research in this area.

TRENDS IN CELL BIOLOGY (2021)

Article Biochemistry & Molecular Biology

The Bul1/2 Alpha-Arrestins Promote Ubiquitylation and Endocytosis of the Can1 Permease upon Cycloheximide-Induced TORC1-Hyperactivation

Amalia H. Megarioti et al.

Summary: This study investigates the molecular mechanisms underlying the endocytosis of Can1, the arginine permease, in response to Cycloheximide-induced TORC1 hyperactivation. It reveals that Cycloheximide promotes Rsp5-dependent Can1 ubiquitylation and endocytosis through the Bul1/2 alpha-arrestins, with a short acidic patch sequence at the N-terminus of Can1 playing a crucial role. The results also suggest that Cycloheximide inhibits transporter recycling, contributing to efficient Can1 downregulation, and that Bul1/2-mediated Can1 ubiquitylation occurs independently of the transporter conformation.

INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES (2021)

Article Genetics & Heredity

Drug resistance in diploid yeast is acquired through dominant alleles, haploinsufficiency, gene duplication and aneuploidy

Jordan B. Barney et al.

Summary: This study reveals that diploid yeast cells acquire resistance to the glucose analog, 2-deoxyglucose, through dominant alleles, haploinsufficiency, gene duplication, and aneuploidy, while haploid cells primarily use recessive alleles. The methods of resistance include missense alleles in AMP-activated protein kinase subunits, nonsense alleles in the REG1 gene, and increased expression of hexose transporters. Aneuploidy, although imposing a fitness cost, offers potential reversibility of drug resistance.

PLOS GENETICS (2021)

Review Genetics & Heredity

'Sugarcoating' 2-deoxyglucose: mechanisms that suppress its toxic effects

Martin C. Schmidt et al.

Summary: Yeast and cancer cells rely on glucose fermentation for energy generation, making them sensitive to the toxic glucose analog, 2-deoxyglucose. Understanding the pathways involved in 2-deoxyglucose sensitivity and resistance in these cells can provide insights for designing combinatorial therapies for cancer treatment. Genetic and proteomic studies in yeast have offered new ideas for developing effective treatment strategies.

CURRENT GENETICS (2021)

Article Biochemistry & Molecular Biology

A Cycle of Ubiquitination Regulates Adaptor Function of the Nedd4-Family Ubiquitin Ligase Rsp5

Chris MacDonald et al.

CURRENT BIOLOGY (2020)

Review Biochemistry & Molecular Biology

2-Deoxy-d-Glucose and Its Analogs: From Diagnostic to Therapeutic Agents

B. Pajak et al.

INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES (2020)

Article Chemistry, Multidisciplinary

An Improved ATP FRET Sensor For Yeast Shows Heterogeneity During Nutrient Transitions

Dennis Botman et al.

ACS SENSORS (2020)

Review Cell Biology

Regulation of nutrient transporters by metabolic and environmental stresses

Markus Babst

CURRENT OPINION IN CELL BIOLOGY (2020)

Article Pharmacology & Pharmacy

Cellular toxicity of the metabolic inhibitor 2-deoxyglucose and associated resistance mechanisms

Clotilde Laussel et al.

BIOCHEMICAL PHARMACOLOGY (2020)

Review Biochemistry & Molecular Biology

AMPK-Mediated Regulation of Alpha-Arrestins and Protein Trafficking

Allyson F. O'Donnell et al.

INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES (2019)

Article Biotechnology & Applied Microbiology

Efficient, D-glucose insensitive, growth on D-xylose by an evolutionary engineered Saccharomyces cerevisiae strain

Jeroen G. Nijland et al.

FEMS YEAST RESEARCH (2019)

Review Biochemistry & Molecular Biology

Targeting Metabolism for Cancer Therapy

Alba Luengo et al.

CELL CHEMICAL BIOLOGY (2017)

Article Biochemistry & Molecular Biology

Regulation of the Yeast Hxt6 Hexose Transporter by the Rod1 α-Arrestin, the Snf1 Protein Kinase, and the Bmh2 14-3-3 Protein

Vicent Llopis-Torregrosa et al.

JOURNAL OF BIOLOGICAL CHEMISTRY (2016)

Review Pharmacology & Pharmacy

Regulation of AMP-activated protein kinase by natural and synthetic activators

David Grahame Hardie

ACTA PHARMACEUTICA SINICA B (2016)

Article Biotechnology & Applied Microbiology

An engineered cryptic Hxt11 sugar transporter facilitates glucose-xylose co-consumption in Saccharomyces cerevisiae

Hyun Yong Shin et al.

BIOTECHNOLOGY FOR BIOFUELS (2015)

Article Biochemistry & Molecular Biology

Differential effects of AMPK agonists on cell growth and metabolism

E. E. Vincent et al.

ONCOGENE (2015)

Article Multidisciplinary Sciences

Assessing Glucose Uptake through the Yeast Hexose Transporter 1 (Hxt1)

Adhiraj Roy et al.

PLOS ONE (2015)

Review Biotechnology & Applied Microbiology

Glucose repression in Saccharomyces cerevisiae

Omur Kayikci et al.

FEMS YEAST RESEARCH (2015)

Review Biochemistry & Molecular Biology

The wonders of 2-deoxy-d-glucose

Haibin Xi et al.

IUBMB LIFE (2014)

Article Biochemistry & Molecular Biology

Glucose Starvation Inhibits Autophagy via Vacuolar Hydrolysis and Induces Plasma Membrane Internalization by Down-regulating Recycling

Michael J. Lang et al.

JOURNAL OF BIOLOGICAL CHEMISTRY (2014)

Article Biochemistry & Molecular Biology

Stress Conditions Promote Yeast Gap1 Permease Ubiquitylation and Down-regulation via the Arrestin-like Bul and Aly Proteins

Myriam Crapeau et al.

JOURNAL OF BIOLOGICAL CHEMISTRY (2014)

Article Cell Biology

TopBP1/Dpb11 binds DNA anaphase bridges to prevent genome instability

Susanne M. Germann et al.

JOURNAL OF CELL BIOLOGY (2014)

Article Biochemistry & Molecular Biology

Specific α-Arrestins Negatively Regulate Saccharomyces cerevisiae Pheromone Response by Down-Modulating the G-Protein-Coupled Receptor Ste2

Christopher G. Alvaro et al.

MOLECULAR AND CELLULAR BIOLOGY (2014)

Article Multidisciplinary Sciences

Crystal structure of the human glucose transporter GLUT1

Dong Deng et al.

NATURE (2014)

Article Multidisciplinary Sciences

Engineering of yeast hexose transporters to transport D-xylose without inhibition by D-glucose

Alexander Farwick et al.

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2014)

Article Cell Biology

Ubiquitin-Dependent Sorting in Endocytosis

Robert C. Piper et al.

COLD SPRING HARBOR PERSPECTIVES IN BIOLOGY (2014)

Review Biochemistry & Molecular Biology

The SLC2 (GLUT) family of membrane transporters

Mike Mueckler et al.

MOLECULAR ASPECTS OF MEDICINE (2013)

Article Biochemistry & Molecular Biology

AMPK-Dependent Degradation of TXNIP upon Energy Stress Leads to Enhanced Glucose Uptake via GLUT1

Ning Wu et al.

MOLECULAR CELL (2013)

Article Multidisciplinary Sciences

Mass spectrometry-based metabolomics of single yeast cells

Alfredo J. Ibanez et al.

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2013)

Review Biochemistry & Molecular Biology

Ubiquitin and Membrane Protein Turnover: From Cradle to Grave

Jason A. MacGurn et al.

ANNUAL REVIEW OF BIOCHEMISTRY, VOL 81 (2012)

Article Biochemical Research Methods

An enzymatic photometric assay for 2-deoxyglucose uptake in insulin-responsive tissues and 3T3-L1 adipocytes

Kumiko Saito et al.

ANALYTICAL BIOCHEMISTRY (2011)

Article Biochemistry & Molecular Biology

TORC1 Regulates Endocytosis via Npr1-Mediated Phosphoinhibition of a Ubiquitin Ligase Adaptor

Jason A. MacGurn et al.

Article Biochemistry & Molecular Biology

Alterations at Dispersed Sites Cause Phosphorylation and Activation of SNF1 Protein Kinase during Growth on High Glucose

Milica Momcilovic et al.

JOURNAL OF BIOLOGICAL CHEMISTRY (2011)

Article Biochemistry & Molecular Biology

Dynamic analysis of cytosolic glucose and ATP levels in yeast using optical sensors

Clara Bermejo et al.

BIOCHEMICAL JOURNAL (2010)

Article Multidisciplinary Sciences

A catabolic block does not sufficiently explain how 2-deoxy-D-glucose inhibits cell growth

Markus Ralser et al.

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2008)

Article Biochemistry & Molecular Biology

Access denied: Snf1 activation loop phosphorylation is controlled by availability of the phosphorylated threonine 210 to the PP1 phosphatase

Eric M. Rubenstein et al.

JOURNAL OF BIOLOGICAL CHEMISTRY (2008)

Article Biochemistry & Molecular Biology

Rod1, an arrestin-related protein, is phosphorylated by Snf1-kinase in Saccharomyces cerevisiae

Junro Shinoda et al.

BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS (2007)

Review Microbiology

Glucose signaling in Saccharomyces cerevisiae

GM Santangelo

MICROBIOLOGY AND MOLECULAR BIOLOGY REVIEWS (2006)

Article Multidisciplinary Sciences

Global analysis of protein localization in budding yeast

WK Huh et al.

NATURE (2003)

Article Biochemistry & Molecular Biology

In vivo imaging of the dynamics of glucose uptake in the cytosol of COS-7 cells by fluorescent nanosensors

M Fehr et al.

JOURNAL OF BIOLOGICAL CHEMISTRY (2003)