4.6 Article

Mathematical modeling of the microtubule detyrosination/tyrosination cycle for cell-based drug screening design

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Summary: The study reveals that the stability of microtubules is influenced by the selective recruitment effect of modified microtubule subpopulations. It was found that tyrosination quantitatively tunes CLIP-170 density at the growing plus end, indicating a synergistic upregulation of dynamicity of tyrosinated microtubules by CLIP170 and EB1.

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