期刊
PLOS BIOLOGY
卷 20, 期 6, 页码 -出版社
PUBLIC LIBRARY SCIENCE
DOI: 10.1371/journal.pbio.3001715
关键词
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资金
- European Research Council (FP7/2013-2019 ERC) [615220]
- French Government's Investissement d'Avenir program, Laboratoire d'Excellence Integrative Biology of Emerging Infectious Diseases [ANR-10-LABX-62-IBEID]
- European Research Council (ERC) [615220] Funding Source: European Research Council (ERC)
The origin of RNA interference (RNAi) is usually explained as a defense mechanism, but we propose a neutral evolutionary hypothesis suggesting that RNAi is formed through constructive neutral evolution (CNE) from a prokaryotic antisense RNA gene regulation mechanism. We argue that RNAi was already present in the ancestor of LECA and had a significant impact on eukaryotic genomic architecture and stability.
The origin of RNA interference (RNAi) is usually explained by a defense-based hypothesis, in which RNAi evolved as a defense against transposable elements (TEs) and RNA viruses and was already present in the last eukaryotic common ancestor (LECA). However, since RNA antisense regulation and double-stranded RNAs (dsRNAs) are ancient and widespread phenomena, the origin of defensive RNAi should have occurred in parallel with its regulative functions to avoid imbalances in gene regulation. Thus, we propose a neutral evolutionary hypothesis for the origin of RNAi in which qualitative system drift from a prokaryotic antisense RNA gene regulation mechanism leads to the formation of RNAi through constructive neutral evolution (CNE). We argue that RNAi was already present in the ancestor of LECA before the need for a new defense system arose and that its presence helped to shape eukaryotic genomic architecture and stability.
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