☆ 4.4 Review

Infections and Changes in Commensal Bacteria and the Pathogenesis of Parkinson's Disease

JOURNAL OF PARKINSONS DISEASE (2022)

相关参考文献

注意：仅列出部分参考文献，下载原文获取全部文献信息。

Review Neurosciences

The Role of Pathogens and Anti-Infective Agents in Parkinson's Disease, from Etiology to Therapeutic Implications

Si Shen et al.

Summary: Parkinson's disease, a debilitating neurodegenerative disorder, may have infection as a key factor in its etiology, with pathogens such as hepatitis C virus, influenza virus, and Helicobacter pylori playing common triggering roles. Anti-infective agents show surprising neuroprotective effects through various mechanisms, making them promising candidates for Parkinson's disease treatment. However, the long-term effects of these drugs, including potential gut dysbiosis, require further consideration and exploration.

JOURNAL OF PARKINSONS DISEASE (2022)

添加到收藏夹

Article Neurosciences

Oral Dysbiosis and Inflammation in Parkinson's Disease

Vanessa Fleury et al.

Summary: The study found changes in the oral microbiome in early and mid-stage PD patients, with good dental and periodontal status in patients, but local inflammation was present in the oral cavity. Further studies are needed to investigate the relationship between oral dysbiosis, inflammation, and the pathogenesis of PD.

JOURNAL OF PARKINSONS DISEASE (2021)

添加到收藏夹

Article Neurosciences

Meta-analysis of the Parkinson's disease gut microbiome suggests alterations linked to intestinal inflammation

Stefano Romano et al.

Summary: Recent studies have shown significant alterations in the gut microbiome of Parkinson's disease patients compared to healthy individuals, which may result in a pro-inflammatory status and impact the symptoms and pathophysiology of the disease.

NPJ PARKINSONS DISEASE (2021)

添加到收藏夹

Article Clinical Neurology

Long-term Risk of Parkinson Disease Following Influenza and Other Infections

Noelle M. Cocoros et al.

Summary: This study found that influenza was associated with Parkinson disease diagnoses more than 10 years after infection, while other infections had weaker associations with Parkinson disease more than 10 years after infection. These results suggest a link between influenza and Parkinson disease, but do not prove causality. The shorter-term associations of other infections with Parkinson disease may not be causal.

JAMA NEUROLOGY (2021)

添加到收藏夹

Article Microbiology

Fecal microbiota transplantation protects rotenone-induced Parkinson's disease mice via suppressing inflammation mediated by the lipopolysaccharide-TLR4 signaling pathway through the microbiota-gut-brain axis

Zhe Zhao et al.

Summary: This study demonstrates that FMT treatment can correct gut microbiota dysbiosis and ameliorate the rotenone-induced PD mouse model, possibly playing a significant role in suppressing inflammation via the LPS-TLR4 signaling pathway in both the gut and the brain. Furthermore, the study proves the involvement of rotenone-induced microbiota dysbiosis in the genesis of PD through the microbiota-gut-brain axis.

MICROBIOME (2021)

添加到收藏夹

Article Clinical Neurology

SARS-CoV-2-related encephalitis with prominent parkinsonism: clinical and FDG-PET correlates in two patients

Mauro Morassi et al.

Summary: This study presents the clinical and neuroimaging findings of two patients with COVID-19-related encephalopathy and prominent parkinsonism, suggesting a possible immune-mediated etiology in one case. Despite the lack of response to immunotherapy, FDG-PET/CT results displayed distinctive brain metabolic changes reminiscent of post-encephalitic parkinsonism, highlighting the neurological complications possibly triggered by SARS-CoV-2 infection.

JOURNAL OF NEUROLOGY (2021)

添加到收藏夹

Article Neurosciences

Deep nasal sinus cavity microbiota dysbiosis in Parkinson's disease

Gian Pal et al.

Summary: This study demonstrates that the olfactory microbial communities of PD individuals are more similar to those of their spousal controls than to non-household controls. Significantly different abundant taxa were identified in comparisons between PD and spousal controls, as well as between PD and non-spousal controls. Additionally, potential pathobionts such as Moraxella catarrhalis were detected in PD subjects and were correlated with more severe motor scores.

NPJ PARKINSONS DISEASE (2021)

添加到收藏夹

Review Neurosciences

Microglial Implications in SARS-CoV-2 Infection and COVID-19: Lessons From Viral RNA Neurotropism and Possible Relevance to Parkinson's Disease

Ifeoluwa O. Awogbindin et al.

Summary: Since December 2019, humanity has been facing the devastating SARS-CoV-2 outbreak, resulting in over 3.1 million deaths globally. SARS-CoV-2 infection may lead to neurological symptoms and potentially cause chronic or permanent changes to neural tissues.

FRONTIERS IN CELLULAR NEUROSCIENCE (2021)

添加到收藏夹

Article Neurosciences

Vagus Nerve and Stomach Synucleinopathy in Parkinson's Disease, Incidental Lewy Body Disease, and Normal Elderly Subjects: Evidence Against the Body-First Hypothesis

Thomas G. Beach et al.

Summary: The study found that there was no pSyn in the vagus nerve and stomach of subjects without brain pSyn, supporting the hypothesis that pSyn may originate in the brain rather than from an exogenous pathogen passing through the gastric mucosa. Presence of pSyn in the vagus nerve and stomach of a subset of ILBD cases suggests that synucleinopathy within the peripheral nervous system may occur at preclinical stages of Lewy body disease.

JOURNAL OF PARKINSONS DISEASE (2021)

添加到收藏夹

Article Microbiology

Oral Factors That Impact the Oral Microbiota in Parkinson's Disease

Natalia S. Rozas et al.

Summary: This study found significant differences in the oral microbiota of patients with PD compared to healthy controls, possibly due to factors such as dysphagia, drooling, and salivary pH. Understanding the factors influencing their oral microbiota could lead to the development of diagnostic and treatment strategies to improve the quality of life and survival of these patients.

MICROORGANISMS (2021)

添加到收藏夹

Article Microbiology

No Metagenomic Evidence of Causative Viral Pathogens in Postencephalitic Parkinsonism Following Encephalitis Lethargica

Daniel Cadar et al.

Summary: Postencephalitic parkinsonism (PEP) is a disease of unknown etiology following encephalitis lethargica (EL) in the 1920s. It may be caused by an unknown viral pathogen or post-infectious immunopathology. Metagenomic next-generation sequencing has not revealed the presence of a specific viral pathogen in PEP tissue samples, suggesting an immune-mediated etiology.

MICROORGANISMS (2021)

添加到收藏夹

Article Neurosciences

Chronic stress-induced gut dysfunction exacerbates Parkinson's disease phenotype and pathology in a rotenone-induced mouse model of Parkinson's disease

Hemraj B. Dodiya et al.

NEUROBIOLOGY OF DISEASE (2020)

添加到收藏夹

Article Biology

A gut bacterial amyloid promotes α-synuclein aggregation and motor impairment in mice

Timothy R. Sampson et al.

ELIFE (2020)

添加到收藏夹

Article Behavioral Sciences

Bacterial, viral, and fungal infection-related risk of Parkinson's disease: Meta-analysis of cohort and case-control studies

Hui Wang et al.

BRAIN AND BEHAVIOR (2020)

添加到收藏夹

Review Endocrinology & Metabolism

The Role of Short-Chain Fatty Acids From Gut Microbiota in Gut-Brain Communication

Ygor Parladore Silva et al.

FRONTIERS IN ENDOCRINOLOGY (2020)

添加到收藏夹

Review Gastroenterology & Hepatology

Microbiome 101: Studying, Analyzing, and Interpreting Gut Microbiome Data for Clinicians

Celeste Allaband et al.

CLINICAL GASTROENTEROLOGY AND HEPATOLOGY (2019)

添加到收藏夹

Review Biotechnology & Applied Microbiology

The Association between Toxoplasma gondii Infection and Risk of Parkinson's Disease: A Systematic Review and Meta-Analysis

Zonglei Zhou et al.

BIOMED RESEARCH INTERNATIONAL (2019)

添加到收藏夹

Editorial Material Clinical Neurology

Is Interferon Therapy for Hepatitis C Infection a Treatable Risk Factor for Parkinson Disease?

Adolfo Ramirez-Zamora et al.

JAMA NEUROLOGY (2019)

添加到收藏夹

Article Clinical Neurology

Association of Antiviral Therapy With Risk of Parkinson Disease in Patients With Chronic Hepatitis C Virus Infection

Wey-Yil Lin et al.

JAMA NEUROLOGY (2019)

添加到收藏夹

Article Clinical Neurology

Malassezia and Parkinson's Disease

Martin Laurence et al.

FRONTIERS IN NEUROLOGY (2019)

添加到收藏夹

Review Neurosciences

Brain-First versus Gut-First Parkinson's Disease: A Hypothesis

Per Borghammer et al.

JOURNAL OF PARKINSONS DISEASE (2019)

添加到收藏夹

Article Neurosciences

Impact of infection on risk of Parkinson's disease: a quantitative assessment of case-control and cohort studies

Lei Meng et al.

JOURNAL OF NEUROVIROLOGY (2019)

添加到收藏夹

Article Clinical Neurology

The Nasal and Gut Microbiome in Parkinson's Disease and Idiopathic Rapid Eye Movement Sleep Behavior Disorder

Anna Heintz-Buschart et al.

MOVEMENT DISORDERS (2018)

添加到收藏夹

Article Immunology

Neuroprotective effects of fecal microbiota transplantation on MPTP-induced Parkinson's disease mice: Gut microbiota, glial reaction and TLRLI/TNF-α signaling pathway

Meng-Fei Sun et al.

BRAIN BEHAVIOR AND IMMUNITY (2018)

添加到收藏夹

Article Neurosciences

Inoculation of α-synuclein preformed fibrils into the mouse gastrointestinal tract induces Lewy body-like aggregates in the brainstem via the vagus nerve

Norihito Uemura et al.

MOLECULAR NEURODEGENERATION (2018)

添加到收藏夹

Review Clinical Neurology

H-pylori and Parkinson's disease: Meta-analyses including clinical severity

Efthimios Dardiotis et al.

CLINICAL NEUROLOGY AND NEUROSURGERY (2018)

添加到收藏夹

Article Clinical Neurology

Spread of aggregates after olfactory bulb injection of alpha-synuclein fibrils is associated with early neuronal loss and is reduced long term

Nolwen L. Rey et al.

ACTA NEUROPATHOLOGICA (2018)

添加到收藏夹

Article Clinical Neurology

Oral and nasal microbiota in Parkinson's disease

Pedro A. B. Pereira et al.

PARKINSONISM & RELATED DISORDERS (2017)

添加到收藏夹

Article Medicine, General & Internal

Toxoplasma gondii exposure and Parkinson's disease: a case-control study

Cosme Alvarado-Esquivel et al.

BMJ OPEN (2017)

添加到收藏夹

Review Neurosciences

Imaging Parkinson's disease below the neck

Per Borghammer et al.

NPJ PARKINSONS DISEASE (2017)

添加到收藏夹

Review Neurosciences

The gut-brain axis: is intestinal inflammation a silent driver of Parkinson's disease pathogenesis?

Madelyn C. Houser et al.

NPJ PARKINSONS DISEASE (2017)

添加到收藏夹

Article Clinical Neurology

Hepatitis C virus infection as a risk factor for Parkinson disease

Hsin-Hsi Tsai et al.

NEUROLOGY (2016)

添加到收藏夹

Article Biochemistry & Molecular Biology

Gut Microbiota Regulate Motor Deficits and Neuroinflammation in a Model of Parkinson's Disease

Timothy R. Sampson et al.

CELL (2016)

添加到收藏夹

Article Clinical Neurology

Aberrations in Peripheral Inflammatory Cytokine Levels in Parkinson Disease A Systematic Review and Meta-analysis

Xiao-Yan Qin et al.

JAMA NEUROLOGY (2016)

添加到收藏夹

Article Multidisciplinary Sciences

Exposure to bacterial endotoxin generates a distinct strain of α-synuclein fibril

Changyoun Kim et al.

SCIENTIFIC REPORTS (2016)

添加到收藏夹

Article Gastroenterology & Hepatology

Hepatitis C virus infection: a risk factor for Parkinson's disease

W. Y. -Y. Wu et al.

JOURNAL OF VIRAL HEPATITIS (2015)

添加到收藏夹

Article Clinical Neurology

Colonic Bacterial Composition in Parkinson's Disease

Ali Keshavarzian et al.

MOVEMENT DISORDERS (2015)

添加到收藏夹

Article Clinical Neurology

Treatment for Helicobacter pylori infection and risk of parkinson's disease in Denmark

H. H. Nielsen et al.

EUROPEAN JOURNAL OF NEUROLOGY (2012)

添加到收藏夹

Article Infectious Diseases

Parkinson's disease or Parkinson symptoms following seasonal influenza

Stephen Toovey et al.

INFLUENZA AND OTHER RESPIRATORY VIRUSES (2011)

添加到收藏夹

Article Immunology

The acute inflammatory response to intranigral α-synuclein differs significantly from intranigral lipopolysaccharide and is exacerbated by peripheral inflammation

Yvonne Couch et al.

JOURNAL OF NEUROINFLAMMATION (2011)

添加到收藏夹

Article Multidisciplinary Sciences

Immunolocalization of Influenza A Virus and Markers of Inflammation in the Human Parkinson's Disease Brain

Troy T. Rohn et al.

PLOS ONE (2011)

添加到收藏夹

Article Neurosciences

The probable relation between Toxoplasma gondii and Parkinson's disease

Ozlem Miman et al.

NEUROSCIENCE LETTERS (2010)

添加到收藏夹

Article Neurosciences

Gastric α-synuclein immunoreactive inclusions in Meissner's and Auerbach's plexuses in cases staged for Parkinson's disease-related brain pathology

H Braak et al.

NEUROSCIENCE LETTERS (2006)

添加到收藏夹

© Peeref 2019-2024. All rights reserved.