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Article
Hematology
Chor-Wing Sing et al.
Summary: Studies found no increased risk of hematological abnormalities after CoronaVac vaccination, but an increased risk of leukopenia was observed shortly after the second dose of BNT162b2. However, the incidence was much lower than following SARS-CoV-2 infections. The benefits of COVID-19 vaccination still outweigh the risk of hematological abnormalities.
AMERICAN JOURNAL OF HEMATOLOGY
(2022)
Article
Biotechnology & Applied Microbiology
Haya Omeish et al.
Summary: The study found that people in Jordan experienced more side effects with the AstraZeneca vaccine followed by the Pfizer vaccine and the least one is the Sinopharm vaccine. These side effects include symptoms such as pain at the injection site, fatigue, headache, and nausea, with most individuals not considering them severe.
HUMAN VACCINES & IMMUNOTHERAPEUTICS
(2022)
Article
Endocrinology & Metabolism
Mikiko Watanabe et al.
Summary: Variables such as increased waist circumference, smoking, hypertension, and longer time elapsed since vaccination were associated with lower antibody titres following COVID-19 mRNA vaccination. This suggests that individuals with central obesity, hypertension, and smoking may benefit from earlier vaccine boosters or different vaccination schedules to ensure adequate immune response.
DIABETES-METABOLISM RESEARCH AND REVIEWS
(2022)
Article
Immunology
Luca Coppeta et al.
Summary: This retrospective study evaluated the determinants of serological protection in vaccinated healthcare workers and found that 99.5% of them developed protective antibodies that were maintained for as long as 250 days after the second dose of the BNT162b2 vaccine. The antibody titer observed at the second evaluation was significantly related to the primary response, evaluation time interval, and previous history of SARS-CoV-2 infection. Importantly, none of the study participants contracted severe COVID-19 during the observation period.
Article
Public, Environmental & Occupational Health
Maria Elena Camacho Moll et al.
Summary: This study compared the extension and severity of self-reported side effects of seven COVID-19 vaccines in the Mexican population and evaluated the association of vaccine type, sex, age, comorbidity, and history of allergies with the extent and severity of side effects. The results showed that ChAdOx1 and Gam-COVID-Vac had the highest rate of side effects in the first dose, while mRNA-1273 had the highest rate of side effects in the second dose. Young age, female sex, comorbidity, and history of allergies were associated with greater extension and severity of side effects.
FRONTIERS IN PUBLIC HEALTH
(2022)
Article
Endocrinology & Metabolism
Hind B. Almufty et al.
Summary: This study aimed to investigate potential side effects of COVID-19 vaccines, associated risk factors, and compare three vaccines available in Iraq. Results showed that symptoms post-vaccination were mostly mild to moderate, with fatigue, injection site reactions, fever, myalgia, headache, and chills being the most reported. Factors like younger age, female gender, history of COVID-19, comorbidities, and receiving the AstraZeneca vaccine were associated with higher risk of adverse reactions.
DIABETES & METABOLIC SYNDROME-CLINICAL RESEARCH & REVIEWS
(2021)
Article
Medicine, General & Internal
Merryn Voysey et al.
Summary: The ChAdOx1 nCoV-19 vaccine has been shown to have an acceptable safety profile and effectiveness against symptomatic COVID-19, with higher efficacy observed in the group that received a low dose followed by a standard dose.
Review
Geriatrics & Gerontology
Sameer Mohammad et al.
Summary: The COVID-19 pandemic has infected millions and caused over a million deaths, with age and underlying health conditions being major factors for severity and mortality. Obesity has emerged as a new risk factor for severe disease and death due to COVID-19.
Editorial Material
Hematology
Eun-Ju Lee et al.
AMERICAN JOURNAL OF HEMATOLOGY
(2021)
Review
Allergy
Vanitha Sampath et al.
Summary: Vaccines are crucial tools in public health, with the COVID-19 vaccines expected to have a positive impact globally. While serious allergic reactions are rare, it is important to consider their mechanisms, clinical implications, and potential causes, as well as to review implications for individual diagnosis, management, and vaccine manufacturing for future research.
Article
Environmental Sciences
Abanoub Riad et al.
Summary: The study revealed that pregnant and lactating women have a high level of COVID-19 vaccine acceptance, but they tend to prefer delaying their vaccination. Factors such as pregnancy trimester, education level, employment status, and previous live births were found to be significant determinants for COVID-19 vaccine acceptance among this population subset.
INTERNATIONAL JOURNAL OF ENVIRONMENTAL RESEARCH AND PUBLIC HEALTH
(2021)
Article
Immunology
Waleed H. Mahallawi et al.
Summary: The study assessed the reactogenicity and immunogenicity of Pfizer and AstraZeneca COVID-19 vaccines among adults in Saudi Arabia. It found that Pfizer vaccine recipients reported fewer vaccine-related complications compared to AstraZeneca vaccine recipients, and the presence of antibodies against the SARS-CoV-2 spike protein may be influenced by factors such as health status and age.
FRONTIERS IN IMMUNOLOGY
(2021)
Editorial Material
Medicine, General & Internal
Johanna Chapin-Bardales et al.
JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION
(2021)
Article
Immunology
Isabel Iguacel et al.
Summary: The study found that non-overweight individuals were more likely to experience fever, vomiting, diarrhea, and chills after receiving the COVID-19 vaccine. However, when adjusting for age, sex, education, medication, and vaccine administered, most of these associations were not significant.
Article
Immunology
Stilla Bauernfeind et al.
Summary: This study found that severe adverse reactions after vaccination with the BNT162b2 vaccine can significantly impact humoral immune response in men, but not in women or T-cell-mediated immune response.
Article
Infectious Diseases
Cristina Menni et al.
Summary: This study investigated the safety and effectiveness of the BNT162b2 and ChAdOx1 nCoV-19 vaccines in a UK community setting. The results showed that the frequencies of side effects from these vaccines were lower than reported in clinical trials, and a significant reduction in the risk of SARS-CoV-2 infection was observed starting at 12 days after vaccination.
LANCET INFECTIOUS DISEASES
(2021)
Article
Medicine, General & Internal
Alexis L. Beatty et al.
Summary: This study found that factors associated with greater odds of adverse effects after COVID-19 vaccination included receiving full vaccination dose, vaccine brand, younger age, female sex, and having a prior COVID-19 infection. Serious vaccine adverse effects were rare in this real-world cohort.
Article
Biochemistry & Molecular Biology
Joseph E. Ebinger et al.
Summary: Virus-specific antibody levels after a single dose of the BNT162b2 vaccine in individuals previously infected with SARS-CoV-2 are similar to levels after two doses of the vaccine in infection-naive individuals. Post-vaccine symptoms were more prominent for those with prior infection after the first dose, but symptomology was similar between groups after the second dose.
Article
Medicine, General & Internal
Andreas Greinacher et al.
Summary: After vaccination with ChAdOx1 nCov-19, rare immune thrombotic thrombocytopenia can occur due to platelet-activating antibodies against PF4, resulting in various thrombotic events. Most patients in this case series were women, with fatal outcomes such as cerebral venous thrombosis and intracranial hemorrhage. Additional studies are needed to further investigate and understand this phenomenon.
NEW ENGLAND JOURNAL OF MEDICINE
(2021)
Editorial Material
Medicine, General & Internal
Paul R. Hunter
BMJ-BRITISH MEDICAL JOURNAL
(2021)
Article
Public, Environmental & Occupational Health
David K. Shay et al.
MMWR-MORBIDITY AND MORTALITY WEEKLY REPORT
(2021)
Article
Medicine, General & Internal
Marc E. Wolf et al.
Summary: The study focused on clinical manifestations and management of patients with cranial venous sinus thrombosis following exposure to the COVID-19 vaccine AstraZeneca, showing that these patients shared similarities in diagnosis and treatment processes.
JOURNAL OF CLINICAL MEDICINE
(2021)
Article
Immunology
Mansour Tobaiqy et al.
Summary: The development of safe and effective vaccines against COVID-19 is crucial in the fight against the pandemic. Although some thrombotic adverse reactions were associated with the Oxford-AstraZeneca vaccine, the European Medicines Agency affirmed the vaccine's safety and effectiveness, with the benefits outweighing the risks. Conducting further analyses based on more detailed thrombotic adverse event reports may help evaluate causality with higher specificity.
Review
Medicine, General & Internal
Bogdan Doroftei et al.
Summary: After analyzing 19 relevant articles, it was concluded that among the eleven vaccines, Pfizer-BioNTech (about 95%), Moderna (about 94%), and Sputnik V (about 92%) showed an efficacy greater than 90%, while Oxford-AstraZeneca was only about 81% effective. Additionally, Moderna, Sputnik V, and Oxford-AstraZeneca also reduced the occurrence of severe adverse reactions.
Article
Biology
Alexander G. Mathioudakis et al.
Summary: The study compares the safety, tolerability, and reactogenicity of different COVID-19 vaccines among various recipient groups. Those who had a prior COVID-19 infection were found to have an increased risk of vaccination side effects, with mRNA vaccines causing milder systemic reactions but more local reactions compared to viral vector-based vaccines.
Article
Infectious Diseases
Annabel A. Powell et al.
Summary: Adults receiving heterologous COVID-19 immunisation with mRNA or adenoviral-vector vaccines had higher reactogenicity rates, especially among those aged over 50, women, and individuals with prior symptomatic/confirmed COVID-19. Those who received heterologous schedules after severe first-dose reactions may have lower reactogenicity after the second dose, depending on the specific combination of vaccines used.
Article
Medicine, General & Internal
Mohamed Adam et al.
Summary: The study found that the most common side effects reported by participants in the Aseer region of Saudi Arabia after receiving the COVID-19 vaccines were fever, myalgia, malaise, muscle and joint pain, and headache. Symptoms were more common in males than in females. Despite a certain infection rate, the side effects of COVID-19 vaccines were consistent with the manufacturers' data.
PATIENT PREFERENCE AND ADHERENCE
(2021)
Article
Immunology
Osama Abu-Hammad et al.
Summary: The survey conducted among healthcare professionals who received COVID-19 vaccines in Jordan showed that around 18% and 31% reported no side effects after the first and second doses respectively. Most of the side effects were local, while systemic side effects like fatigue, myalgia, headache, and fever were more common after the first dose, particularly associated with the AstraZeneca vaccine and age <= 45 years. No serious side effects were reported, indicating that the side effects of COVID-19 vaccines in Jordan are similar to what have been known before. Further studies with larger sample sizes and longer follow-up periods are needed to monitor potential serious and long-term side effects.
Article
Immunology
Abdulaziz Alhazmi et al.
Summary: A study conducted in Saudi Arabia found that side effects reported after receiving Oxford-AstraZeneca and Pfizer-BioNTech vaccines are similar to those reported in clinical trials, indicating the safety of these vaccines. Most participants reported fatigue and pain at the injection site as common side effects. Further research is needed to assess the effectiveness of these vaccines in protecting against SARS-CoV-2 reinfections.
Article
Immunology
Ma'mon M. Hatmal et al.
Summary: The study confirms the safety of authorized COVID-19 vaccines, with most side effects being mild to moderate, indicating the body's immune system is building protection. Many individuals feel more reassured after vaccination and recommend others to get vaccinated.
Article
Medicine, General & Internal
Liane S. Canas et al.
Summary: This study aimed to compare early post-vaccination symptoms in individuals who subsequently tested positive or negative for SARS-CoV-2. The findings suggest that it is challenging to differentiate post-vaccination side-effects alone from early COVID-19, and individuals presenting with systemic symptoms post-vaccination should be tested for SARS-CoV-2 or quarantining to prevent community spread.
Review
Biochemistry & Molecular Biology
Rimple Jeet Kaur et al.
Summary: This study systematically reviewed the safety data from published COVID-19 vaccine trials, indicating that most reactions were mild to moderate, while a few were severe, and all reactions resolved within 3-4 days. COVID-19 vaccines may be safe, but long-term post-marketing surveillance in high-risk vulnerable populations is needed.
INDIAN JOURNAL OF CLINICAL BIOCHEMISTRY
(2021)
Review
Endocrinology & Metabolism
Robert Ross et al.
NATURE REVIEWS ENDOCRINOLOGY
(2020)
Article
Medicine, General & Internal
Feng-Cai Zhu et al.
Article
Medicine, General & Internal
Shengli Xia et al.
JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION
(2020)
Article
Medicine, General & Internal
Pedro M. Folegatti et al.
Article
Multidisciplinary Sciences
Mark J. Mulligan et al.
Article
Medicine, General & Internal
Edward E. Walsh et al.
NEW ENGLAND JOURNAL OF MEDICINE
(2020)
Article
Medicine, General & Internal
Maheshi N. Ramasamy et al.
Review
Biochemistry & Molecular Biology
Yetian Dong et al.
SIGNAL TRANSDUCTION AND TARGETED THERAPY
(2020)
Article
Immunology
Emily A. Voigt et al.
FRONTIERS IN IMMUNOLOGY
(2019)
Review
Nutrition & Dietetics
Catherine J. Andersen et al.
ADVANCES IN NUTRITION
(2016)
Review
Immunology
Scott D. Painter et al.
Article
Endocrinology & Metabolism
Andy McLarnon
Nature Reviews Endocrinology
(2011)
