4.7 Article

Development and validation of a trans-ancestry polygenic risk score for type 2 diabetes in diverse populations

相关参考文献

注意:仅列出部分参考文献,下载原文获取全部文献信息。
Article Genetics & Heredity

Large uncertainty in individual polygenic risk score estimation impacts PRS-based risk stratification

Yi Ding et al.

Summary: The study shows that Bayesian PRS methods can estimate the individual PRS variance and generate well-calibrated credible intervals through posterior sampling. Analysis of real traits in the UK Biobank demonstrates that large uncertainty in polygenic risk score (PRS) estimates at the individual level impacts the interpretation of subsequent analyses such as PRS-based stratification.

NATURE GENETICS (2022)

Article Genetics & Heredity

Multi-ancestry genetic study of type 2 diabetes highlights the power of diverse populations for discovery and translation

Anubha Mahajan et al.

Summary: By conducting genome-wide association studies (GWAS) on ancestrally diverse populations, we identified 237 loci associated with type 2 diabetes (T2D) and further fine-mapped these loci. The majority of T2D associations were found to be driven by a single variant. In addition, our study showed that genetic risk scores derived from ancestrally diverse populations can enhance the transferability of T2D prediction across different populations.

NATURE GENETICS (2022)

Article Genetics & Heredity

Leveraging fine-mapping and multipopulation training data to improve cross-population polygenic risk scores

Omer Weissbrod et al.

Summary: PolyPred and PolyPred(+) methods greatly improve cross-population polygenic prediction accuracy, particularly when applied to diseases and complex traits in UK Biobank populations. This is crucial for reducing health disparities in non-European populations.

NATURE GENETICS (2022)

Article Genetics & Heredity

A cross-population atlas of genetic associations for 220 human phenotypes

Saori Sakaue et al.

Summary: The study conducted deep-phenotype genome-wide association studies in BioBank Japan, identifying approximately 5,000 new loci and improving the resolution of the genomic map of human traits. By decomposing matrices of phenome-wide summary statistics, responsible variants and biological mechanisms underlying current disease classifications across populations were pinpointed.

NATURE GENETICS (2021)

Review Medicine, General & Internal

Screening for Prediabetes and Type 2 Diabetes: US Preventive Services Task Force Recommendation Statement

Karina W. Davidson et al.

Summary: Diabetes and prediabetes have significant impacts on health, with screening and preventive interventions for overweight or obese adults aged 35 to 70 being recommended to improve health outcomes.

JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION (2021)

Article Medicine, General & Internal

Trends in Prevalence of Diabetes and Control of Risk Factors in Diabetes Among US Adults, 1999-2018

Li Wang et al.

Summary: The study based on NHANES data from US adults reveals a significant increase in the prevalence of diabetes between 1999-2000 and 2017-2018. Only around 21% of adults with diagnosed diabetes achieved all three risk factor control goals in 2015-2018.

JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION (2021)

Review Biochemistry & Molecular Biology

Systematic Review of Polygenic Risk Scores for Type 1 and Type 2 Diabetes

Felipe Padilla-Martinez et al.

INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES (2020)

Article Cardiac & Cardiovascular Systems

Validation of a Genome-Wide Polygenic Score for Coronary Artery Disease in South Asians

Minxian Wang et al.

JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY (2020)

Article Biochemical Research Methods

LDpred2: better, faster, stronger

Florian Prive et al.

BIOINFORMATICS (2020)

Article Genetics & Heredity

Clinical use of current polygenic risk scores may exacerbate health disparities

Alicia R. Martin et al.

NATURE GENETICS (2019)

Article Multidisciplinary Sciences

Polygenic prediction via Bayesian regression and continuous shrinkage priors

Tian Ge et al.

NATURE COMMUNICATIONS (2019)

Review Biochemistry & Molecular Biology

Towards clinical utility of polygenic risk scores

Samuel A. Lambert et al.

HUMAN MOLECULAR GENETICS (2019)

Article Genetics & Heredity

Personalized risk prediction for type 2 diabetes: the potential of genetic risk scores

Kristi Laell et al.

GENETICS IN MEDICINE (2017)

Article Genetics & Heredity

Multiethnic polygenic risk scores improve risk prediction in diverse populations

Carla Marquez-Luna et al.

GENETIC EPIDEMIOLOGY (2017)

Article Biotechnology & Applied Microbiology

Quality of anticoagulation control and hemorrhage risk among African American and European American warfarin users

Nita A. Limdi et al.

PHARMACOGENETICS AND GENOMICS (2017)

Article Medicine, General & Internal

The Impact of Whole-Genome Sequencing on the Primary Care and Outcomes of Healthy Adult Patients A Pilot Randomized Trial

Jason L. Vassy et al.

ANNALS OF INTERNAL MEDICINE (2017)

Article Genetics & Heredity

Fast and accurate long-range phasing in a UK Biobank cohort

Po-Ru Loh et al.

NATURE GENETICS (2016)

Article Genetics & Heredity

Next-generation genotype imputation service and methods

Sayantan Das et al.

NATURE GENETICS (2016)

Article Medicine, General & Internal

Prevalence of and Trends in Diabetes Among Adults in the United States, 1988-2012

Andy Menke et al.

JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION (2015)

Article Multidisciplinary Sciences

A global reference for human genetic variation

David M. Altshuler et al.

NATURE (2015)

Article Endocrinology & Metabolism

Polygenic Type 2 Diabetes Prediction at the Limit of Common Variant Detection

Jason L. Vassy et al.

DIABETES (2014)

Article Endocrinology & Metabolism

Personalized Genetic Risk Counseling to Motivate Diabetes Prevention A randomized trial

Richard W. Grant et al.

DIABETES CARE (2013)

Review Genetics & Heredity

The Electronic Medical Records and Genomics (eMERGE) Network: past, present, and future

Omri Gottesman et al.

GENETICS IN MEDICINE (2013)

Article Public, Environmental & Occupational Health

Modeling the impact of prevention policies on future diabetes prevalence in the United States: 2010-2030

Edward W. Gregg et al.

POPULATION HEALTH METRICS (2013)

Article Endocrinology & Metabolism

A genotype risk score predicts type 2 diabetes from young adulthood: the CARDIA study

J. L. Vassy et al.

DIABETOLOGIA (2012)

Article Computer Science, Information Systems

Use of diverse electronic medical record systems to identify genetic risk for type 2 diabetes within a genome-wide association study

Abel N. Kho et al.

JOURNAL OF THE AMERICAN MEDICAL INFORMATICS ASSOCIATION (2012)

Article Genetics & Heredity

Estimating Missing Heritability for Disease from Genome-wide Association Studies

Sang Hong Lee et al.

AMERICAN JOURNAL OF HUMAN GENETICS (2011)

Article Medicine, General & Internal

Genotype Score in Addition to Common Risk Factors for Prediction of Type 2 Diabetes

James B. Meigs et al.

NEW ENGLAND JOURNAL OF MEDICINE (2008)

Article Public, Environmental & Occupational Health

The reasons for geographic and racial differences in stroke study: Objectives and design

VJ Howard et al.

NEUROEPIDEMIOLOGY (2005)

Article Endocrinology & Metabolism

Parental transmission of type 2 diabetes - The Framingham Offspring Study

JB Meigs et al.

DIABETES (2000)

Article Public, Environmental & Occupational Health

NHLBI Family Blood Pressure Program: Methodology and recruitment in the HyperGEN network

RR Williams et al.

ANNALS OF EPIDEMIOLOGY (2000)