4.5 Review

Neural Oscillations in Aversively Motivated Behavior

期刊

出版社

FRONTIERS MEDIA SA
DOI: 10.3389/fnbeh.2022.936036

关键词

oscillations; theta; gamma; fear; anxiety; hippocampus; medial prefrontal cortex; amygdala

资金

  1. National Institutes of Health [R01MH065961, R01MH117852]

向作者/读者索取更多资源

This article reviews the oscillatory correlates of fear and anxiety, with a focus on theta and gamma rhythms. The study finds that hippocampal network oscillations play a role in integrating spatial and motivational information during anxiety states, and these oscillations also synchronize different brain structures to guide adaptive behavior. Additionally, theta and gamma oscillations are important in the encoding and retrieval of fear memories.
Fear and anxiety-based disorders are highly debilitating and among the most prevalent psychiatric disorders. These disorders are associated with abnormal network oscillations in the brain, yet a comprehensive understanding of the role of network oscillations in the regulation of aversively motivated behavior is lacking. In this review, we examine the oscillatory correlates of fear and anxiety with a particular focus on rhythms in the theta and gamma-range. First, we describe neural oscillations and their link to neural function by detailing the role of well-studied theta and gamma rhythms to spatial and memory functions of the hippocampus. We then describe how theta and gamma oscillations act to synchronize brain structures to guide adaptive fear and anxiety-like behavior. In short, that hippocampal network oscillations act to integrate spatial information with motivationally salient information from the amygdala during states of anxiety before routing this information via theta oscillations to appropriate target regions, such as the prefrontal cortex. Moreover, theta and gamma oscillations develop in the amygdala and neocortical areas during the encoding of fear memories, and interregional synchronization reflects the retrieval of both recent and remotely encoded fear memories. Finally, we argue that the thalamic nucleus reuniens represents a key node synchronizing prefrontal-hippocampal theta dynamics for the retrieval of episodic extinction memories in the hippocampus.

作者

我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。

评论

主要评分

4.5
评分不足

次要评分

新颖性
-
重要性
-
科学严谨性
-
评价这篇论文

推荐

暂无数据
暂无数据