4.6 Article

Resting state electroencephalographic rhythms are affected by immediately preceding memory demands in cognitively unimpaired elderly and patients with mild cognitive impairment

期刊

FRONTIERS IN AGING NEUROSCIENCE
卷 14, 期 -, 页码 -

出版社

FRONTIERS MEDIA SA
DOI: 10.3389/fnagi.2022.907130

关键词

resting state EEG power; alpha oscillations; cortical arousal; mild cognitive impairment; cognitive engagement; memory; aging

资金

  1. Spanish Government, Ministerio de Ciencia e Innovacion [PSI2017-89389-C2-R, PID2020-114521RB-C21/C22]
  2. Galician Government (Xunta de Galicia)
  3. Axudas para a Consolidacion e Estruturacion de Unidades de Investigacion Competitivas do Sistema Universitario de Galicia: GRC [GI-1807-USC]
  4. ERDF/FEDER funds [PSI2017-89389-C2-R, PID2020-114521RB-C21/C22]
  5. Fundacao para a Ciencia e a Tecnologia (FCT)
  6. Ministerio de Ciencia e Innovacion [GI-1807-USC]
  7. [ED431-2017/27]
  8. [ED431C-2021/04]
  9. [SFRH/BPD/120111/2016]
  10. [PRE2018-085514]

向作者/读者索取更多资源

This exploratory study investigated the effect of cognitive tasks on cortical arousal during the resting state in aged individuals. The results showed that engagement in memory tasks perturbed cortical arousal for more than 5 minutes after task completion, and this effect was dependent on participants' global cognitive status.
Experiments on event-related electroencephalographic oscillations in aged people typically include blocks of cognitive tasks with a few minutes of interval between them. The present exploratory study tested the effect of being engaged on cognitive tasks over the resting state cortical arousal after task completion, and whether it differs according to the level of the participant's cognitive decline. To investigate this issue, we used a local database including data in 30 healthy cognitively unimpaired (CU) persons and 40 matched patients with amnestic mild cognitive impairment (aMCI). They had been involved in 2 memory tasks for about 40 min and underwent resting-state electroencephalographic (rsEEG) recording after 5 min from the task end. eLORETA freeware estimated rsEEG alpha source activity as an index of general cortical arousal. In the CU but not aMCI group, there was a negative correlation between memory tasks performance and posterior rsEEG alpha source activity. The better the memory tasks performance, the lower the posterior alpha activity (i.e., higher cortical arousal). There was also a negative correlation between neuropsychological test scores of global cognitive status and alpha source activity. These results suggest that engagement in memory tasks may perturb background brain arousal for more than 5 min after the tasks end, and that this effect are dependent on participants global cognitive status. Future studies in CU and aMCI groups may cross-validate and extend these results with experiments including (1) rsEEG recordings before memory tasks and (2) post-tasks rsEEG recordings after 5, 15, and 30 min.

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