期刊
FRONTIERS IN AGING NEUROSCIENCE
卷 14, 期 -, 页码 -出版社
FRONTIERS MEDIA SA
DOI: 10.3389/fnagi.2022.914017
关键词
target novelty; artificial intelligence; time machine; multi-omics
资金
- Robert Packard Center for ALS Research
- Target ALS consortia
- Frick Foundation for ALS Research
In this study, an AI-driven target discovery platform called PandaOmics was used to analyze the expression profiles of CNS samples and direct iPSC-derived motor neurons from public datasets and Answer ALS. The study identified 17 high-confidence and 11 novel therapeutic targets, and verified their therapeutic effects in a fruit fly model. The research provides new insights into ALS pathophysiology and demonstrates the ability of AI to speed up the target discovery process.
Amyotrophic lateral sclerosis (ALS) is a severe neurodegenerative disease with ill-defined pathogenesis, calling for urgent developments of new therapeutic regimens. Herein, we applied PandaOmics, an AI-driven target discovery platform, to analyze the expression profiles of central nervous system (CNS) samples (237 cases; 91 controls) from public datasets, and direct iPSC-derived motor neurons (diMNs) (135 cases; 31 controls) from Answer ALS. Seventeen high-confidence and eleven novel therapeutic targets were identified and will be released onto ALS.AI (). Among the proposed targets screened in the c9ALS Drosophila model, we verified 8 unreported genes (KCNB2, KCNS3, ADRA2B, NR3C1, P2RY14, PPP3CB, PTPRC, and RARA) whose suppression strongly rescues eye neurodegeneration. Dysregulated pathways identified from CNS and diMN data characterize different stages of disease development. Altogether, our study provides new insights into ALS pathophysiology and demonstrates how AI speeds up the target discovery process, and opens up new opportunities for therapeutic interventions.
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