期刊
DEVELOPMENTAL COGNITIVE NEUROSCIENCE
卷 56, 期 -, 页码 -出版社
ELSEVIER SCI LTD
DOI: 10.1016/j.dcn.2022.101124
关键词
Lead exposure; Maternal stress; Prenatal exposure; Different stage of pregnancy; Cognitive development; Birth cohort
资金
- National Natural Science Foundation of China [81673189, 81974486]
- Shanghai Municipal Health Commission [GWIII-26, GWIV-26, 2020CXJQ01]
- Shanghai Jiao Tong University School of Medicine, Xinhua Hospital and the National Human Genetic Resources Sharing Service Platform [2005DKA21300]
This study found that both single and combined prenatal exposures to lead/stress impaired infant neurodevelopment, and the effects of combined exposure may be more profound than single exposures. Combined exposure in early pregnancy may be associated with worse neurodevelopmental outcomes than combined exposure around birth, especially in social-emotional development.
Objective: To assess associations of single and combined exposures to lead and stress during different stages of pregnancy with offspring neurodevelopment.Methods: We measured prenatal lead (maternal blood-lead in early-pregnancy and umbilical-cord-blood-lead) and maternal stress levels in Shanghai-Birth-Cohort from 2013 to 2016. Maternal stress was assessed using Center-for-Epidemiological-Studies-Depression-Scale and Self-Rating-Anxiety-Scale during mid-pregnancy. The Ages-Stages-Questionnaires-3 (at 6/12-months-of-age) and Bayley-III (at 24-months-of-age) were both used to assess neurodevelopment. Results: A total of 2132 mother-child pairs with both prenatal lead and stress measurements were included. The geometric-means of blood-lead in early-pregnancy and cord-blood-lead were 1.46 mu g/dL and 1.33 mu g/dL, respectively. Among the study women, 1.89 % and 0.14 % were screened positive for depression and anxiety. Adjusting for related confounders, the combined exposures had stronger adverse associations with offspring social-emotional skills than single exposures; and the combined exposure in early-pregnancy was associated with greater neurodevelopmental differences than combined exposure around-birth, especially in social-emotion at 24 months-of-age [beta (95 %CI): 10.48(-17.42,-3.54) vs. 5.95(-11.53,-0.36)]. Conclusions: Both single and combined prenatal exposures to lead/stress impaired infant neuro-development, and the effects of combined exposure may be more profound than single exposures. Combined exposure in early pregnancy may be associated with worse neurodevelopmental outcomes than combined exposure around birth, especially in social-emotional development.
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