4.8 Article

Hyperosmotic-stress-induced liquid-liquid phase separation of ALS-related proteins in the nucleus

相关参考文献

注意:仅列出部分参考文献,下载原文获取全部文献信息。
Editorial Material Cell Biology

Spatiotemporal dynamic regulation of membraneless organelles by chaperone networks

Dan Li et al.

Summary: Membraneless organelles (MLOs) are condensed metastable phases formed by liquid-liquid phase separation of different proteins and RNAs. Recent studies indicate that molecular chaperones play a crucial role in the dynamic assembly of MLOs, coordinating to maintain protein homeostasis and prevent abnormal protein aggregation.

TRENDS IN CELL BIOLOGY (2022)

Review Cell Biology

Biomolecular condensates at the nexus of cellular stress, protein aggregation disease and ageing

Simon Alberti et al.

Summary: Biomolecular condensates, formed through liquid-liquid phase separation in a tightly regulated manner, have fundamental roles in cellular organization and physiology. Recent studies provide insights into how cellular stress, ageing-related loss of homeostasis, and a decline in protein quality control may contribute to the formation of aberrant, disease-causing condensates.

NATURE REVIEWS MOLECULAR CELL BIOLOGY (2021)

Article Multidisciplinary Sciences

Nuclear pores dilate and constrict in cellulo

Christian E. Zimmerli et al.

Summary: Nuclear pore complexes (NPCs) in eukaryotic cells play a crucial role in mediating nucleocytoplasmic exchange. Recent research using cryo-electron tomography and integrative structural modeling reveals that the conformation of NPCs is highly dynamic and can change in response to cellular energy levels and osmotic stress. The data suggests a model where nuclear envelope membrane tension is linked to NPC conformation.

SCIENCE (2021)

Article Biochemistry & Molecular Biology

Hyperosmotic phase separation: Condensates beyond inclusions, granules and organelles

Ameya P. Jalihal et al.

Summary: Biological liquid-liquid phase separation is a driving force for the assembly of membraneless organelles. Proteins undergo rapid, reversible condensation in response to environmental fluctuations, with molecular crowding playing an important role. Current methods are emerging to visualize, quantify, and modulate intracellular condensates in live cells.

JOURNAL OF BIOLOGICAL CHEMISTRY (2021)

Article Multidisciplinary Sciences

HSP70 chaperones RNA-free TDP-43 into anisotropic intranuclear liquid spherical shells

Haiyang Yu et al.

Summary: This study found that the RNA binding protein TDP-43 forms intranuclear or cytoplasmic aggregates in age-related neurodegenerative diseases. Through mathematical modeling, the primary components of TDP-43 liquid core were identified to be HSP70 family chaperones, and these structures converted to aggregates when ATP levels were reduced.

SCIENCE (2021)

Article Cell Biology

Hyperosmotic stress: in situ chromatin phase separation

Ada L. Olins et al.

NUCLEUS (2020)

Article Biochemistry & Molecular Biology

Hsp27 chaperones FUS phase separation under the modulation of stress-induced phosphorylation

Zhenying Liu et al.

NATURE STRUCTURAL & MOLECULAR BIOLOGY (2020)

Editorial Material Genetics & Heredity

Rapid progressive ALS in a patient with a DNAJC7 loss-of-function mutation

Kang-Yang Jih et al.

NEUROLOGY-GENETICS (2020)

Article Biochemistry & Molecular Biology

Multivalent Proteins Rapidly and Reversibly Phase-Separate upon Osmotic Cell Volume Change

Ameya P. Jalihal et al.

MOLECULAR CELL (2020)

Article Multidisciplinary Sciences

Hsp40 proteins phase separate to chaperone the assembly and maintenance of membraneless organelles

Jinge Gu et al.

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2020)

Review Biochemistry & Molecular Biology

Cellular sensing by phase separation: Using the process, not just the products

Haneul Yoo et al.

JOURNAL OF BIOLOGICAL CHEMISTRY (2019)

Article Multidisciplinary Sciences

Structural basis for reversible amyloids of hnRNPA1 elucidates their role in stress granule assembly

Xinrui Gui et al.

NATURE COMMUNICATIONS (2019)

Article Biochemistry & Molecular Biology

Phase Separation of Zonula Occludens Proteins Drives Formation of Tight Junctions

Oliver Beutel et al.

Article Biochemistry & Molecular Biology

Context-Dependent and Disease-Specific Diversity in Protein Interactions within Stress Granules

Sebastian Markmiller et al.

Article Multidisciplinary Sciences

RNA buffers the phase separation behavior of prion-like RNA binding proteins

Shovamayee Maharana et al.

SCIENCE (2018)

Article Multidisciplinary Sciences

Nuclear egress of TDP-43 and FUS occurs independently of Exportin-1/CRM1

Helena Ederle et al.

SCIENTIFIC REPORTS (2018)

Article Medicine, Research & Experimental

Biology and Pathobiology of TDP-43 and Emergent Therapeutic Strategies

Lin Guo et al.

COLD SPRING HARBOR PERSPECTIVES IN MEDICINE (2017)

Review Cell Biology

Biomolecular condensates: organizers of cellular biochemistry

Salman F. Banani et al.

NATURE REVIEWS MOLECULAR CELL BIOLOGY (2017)

Article Multidisciplinary Sciences

Cell volume change through water efflux impacts cell stiffness and stem cell fate

Ming Guo et al.

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2017)

Review Multidisciplinary Sciences

Liquid phase condensation in cell physiology and disease

Yongdae Shin et al.

SCIENCE (2017)

Article Biochemistry & Molecular Biology

ATPase-Modulated Stress Granules Contain a Diverse Proteome and Substructure

Saumya Jain et al.

Article Cell Biology

Structural, super-resolution microscopy analysis of paraspeckle nuclear body organization

Jason A. West et al.

JOURNAL OF CELL BIOLOGY (2016)

Article Cell Biology

Simple rules for passive diffusion through the nuclear pore complex

Benjamin L. Timney et al.

JOURNAL OF CELL BIOLOGY (2016)

Review Biochemistry & Molecular Biology

Physiological functions and pathobiology of TDP-43 and FUS/TLS proteins

Antonia Ratti et al.

JOURNAL OF NEUROCHEMISTRY (2016)

Article Multidisciplinary Sciences

PML plays both inimical and beneficial roles in HSV-1 replication

Pei Xu et al.

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2016)

Article Biochemistry & Molecular Biology

A Liquid-to-Solid Phase Transition of the ALS Protein FUS Accelerated by Disease Mutation

Avinash Patel et al.

Article Multidisciplinary Sciences

Alternative lengthening of telomeres renders cancer cells hypersensitive to ATR inhibitors

Rachel Litman Flynn et al.

SCIENCE (2015)

Review Cell Biology

Liquid-Liquid Phase Separation in Biology

Anthony A. Hyman et al.

ANNUAL REVIEW OF CELL AND DEVELOPMENTAL BIOLOGY, VOL 30 (2014)

Article Cell Biology

FUS/TLS Assembles Into Stress Granules and Is a Prosurvival Factor During Hyperosmolar Stress

Reddy Ranjith K. Sama et al.

JOURNAL OF CELLULAR PHYSIOLOGY (2013)

Article Biochemistry & Molecular Biology

Macromolecular Crowding Regulates Assembly of mRNA Stress Granules after Osmotic Stress NEW ROLE FOR COMPATIBLE OSMOLYTES

Ouissame Bounedjah et al.

JOURNAL OF BIOLOGICAL CHEMISTRY (2012)

Article Biochemistry & Molecular Biology

Requirements for Stress Granule Recruitment of Fused in Sarcoma (FUS) and TAR DNA-binding Protein of 43 kDa (TDP-43)

Eva Bentmann et al.

JOURNAL OF BIOLOGICAL CHEMISTRY (2012)

Article Multidisciplinary Sciences

Phase transitions in the assembly of multivalent signalling proteins

Pilong Li et al.

NATURE (2012)

Editorial Material Cell Biology

Beyond Stereospecificity: Liquids and Mesoscale Organization of Cytoplasm

Anthony A. Hyman et al.

DEVELOPMENTAL CELL (2011)

Review Multidisciplinary Sciences

Molecular chaperones in protein folding and proteostasis

F. Ulrich Hartl et al.

NATURE (2011)

Article Cell Biology

Nuclear Speckles

David L. Spector et al.

COLD SPRING HARBOR PERSPECTIVES IN BIOLOGY (2011)

Article Biochemistry & Molecular Biology

A long nuclear-retained non-coding RNA regulates synaptogenesis by modulating gene expression

Delphine Bernard et al.

EMBO JOURNAL (2010)

Article Biochemistry & Molecular Biology

Coilin-dependent snRNP assembly is essential for zebrafish embryogenesis

Magdalena Strzelecka et al.

NATURE STRUCTURAL & MOLECULAR BIOLOGY (2010)

Review Cell Biology

RNA granules: post-transcriptional and epigenetic modulators of gene expression

Paul Anderson et al.

NATURE REVIEWS MOLECULAR CELL BIOLOGY (2009)

Article Multidisciplinary Sciences

Germline P Granules Are Liquid Droplets That Localize by Controlled Dissolution/Condensation

Clifford P. Brangwynne et al.

SCIENCE (2009)

Review Physiology

Cellular response to hyperosmotic stresses

Maurice B. Burg et al.

PHYSIOLOGICAL REVIEWS (2007)