4.8 Article

ATGL-dependent white adipose tissue lipolysis controls hepatocyte PPARα activity

相关参考文献

注意:仅列出部分参考文献,下载原文获取全部文献信息。
Article Multidisciplinary Sciences

Fasting improves therapeutic response in hepatocellular carcinoma through p53-dependent metabolic synergism

Jelena Krstic et al.

Summary: Fasting improves the efficacy of sorafenib and sensitizes sorafenib-resistant HCC by preventing the Warburg shift through reduction in glucose and AKT/mTOR signaling. p53 is necessary for the sorafenib-sensitizing effect of fasting.

SCIENCE ADVANCES (2022)

Article Cell Biology

A feed-forward regulatory loop in adipose tissue promotes signaling by the hepatokine FGF21

Myoung Sook Han et al.

Summary: This study demonstrates that JNK signaling in adipocytes results in an increased circulating concentration of FGF21, regulating systemic metabolism. This mechanism of organ crosstalk involves a feed-forward regulatory loop mediated by JNK-regulated FGF21 autocrine signaling in adipocytes, promoting the expression of adiponectin and hepatic expression of FGF21. The novel signaling paradigm connects autocrine and endocrine signaling modes of the same hormone in different tissues.

GENES & DEVELOPMENT (2021)

Article Medicine, Research & Experimental

Discordant hepatic fatty acid oxidation and triglyceride hydrolysis leads to liver disease

Ebru S. Selen et al.

Summary: The study demonstrates the interdependent roles of fatty acid oxidation and triglyceride hydrolysis in liver metabolism, with disruption of their coordination leading to liver disease. Loss of individual components of fatty acid catabolism has largely independent effects on hepatocyte morphology, intermediary metabolism, and gene expression.

JCI INSIGHT (2021)

Article Cell Biology

Lipid Droplets in Brown Adipose Tissue Are Dispensable for Cold-Induced Thermogenesis

Chandramohan Chitraju et al.

CELL REPORTS (2020)

Review Cell Biology

A Dozen Years of Discovery: Insights into the Physiology and Pharmacology of FGF21

Steven A. Kliewer et al.

CELL METABOLISM (2019)

Article Multidisciplinary Sciences

Liver Derived FGF21 Maintains Core Body Temperature During Acute Cold Exposure

Magdalene Ameka et al.

SCIENTIFIC REPORTS (2019)

Article Multidisciplinary Sciences

Metascape provides a biologist-oriented resource for the analysis of systems-level datasets

Yingyao Zhou et al.

NATURE COMMUNICATIONS (2019)

Article Gastroenterology & Hepatology

Hepatic PPARα is critical in the metabolic adaptation to sepsis

Rejane Paumelle et al.

JOURNAL OF HEPATOLOGY (2019)

Article Cell Biology

Insights into the role of hepatocyte PPARα activity in response to fasting

Marion Regnier et al.

MOLECULAR AND CELLULAR ENDOCRINOLOGY (2018)

Review Biochemistry & Molecular Biology

Brown adipocyte glucose metabolism: a heated subject

Mohammed K. Hankir et al.

EMBO REPORTS (2018)

Article Mathematical & Computational Biology

Smooth quantile normalization

Stephanie C. Hicks et al.

BIOSTATISTICS (2018)

Article Biochemistry & Molecular Biology

Liver p53 is stabilized upon starvation and required for amino acid catabolism and gluconeogenesis

Andreas Prokesch et al.

FASEB JOURNAL (2017)

Article Medicine, Research & Experimental

Hepatocyte nuclear factor 1α suppresses steatosis-associated liver cancer by inhibiting PPARγ transcription

Cecilia Patitucci et al.

JOURNAL OF CLINICAL INVESTIGATION (2017)

Article Gastroenterology & Hepatology

Histological subtypes of hepatocellular carcinoma are related to gene mutations and molecular tumour classification

Julien Calderaro et al.

JOURNAL OF HEPATOLOGY (2017)

Article Cell Biology

SerpinB1 Promotes Pancreatic β Cell Proliferation

Abdelfattah El Ouaamari et al.

CELL METABOLISM (2016)

Article Gastroenterology & Hepatology

Liver PPARα is crucial for whole-body fatty acid homeostasis and is protective against NAFLD

Alexandra Montagner et al.

Article Biochemistry & Molecular Biology

Hepatic Fasting-Induced PPARα Activity Does Not Depend on Essential Fatty Acids

Arnaud Polizzi et al.

INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES (2016)

Article Cell Biology

Activation of Human Brown Adipose Tissue by a β3-Adrenergic Receptor Agonist

Aaron M. Cypess et al.

CELL METABOLISM (2015)

Article Biochemical Research Methods

Orchestrating high-throughput genomic analysis with Bioconductor

Wolfgang Huber et al.

NATURE METHODS (2015)

Article Biochemistry & Molecular Biology

limma powers differential expression analyses for RNA-sequencing and microarray studies

Matthew E. Ritchie et al.

NUCLEIC ACIDS RESEARCH (2015)

Review Endocrinology & Metabolism

Transcriptional and Chromatin Regulation during Fasting - The Genomic Era

Ida Goldstein et al.

TRENDS IN ENDOCRINOLOGY AND METABOLISM (2015)

Article Endocrinology & Metabolism

Evidence for fatty acids mediating CL 316,243-induced reductions in blood glucose in mice

Rebecca E. K. MacPherson et al.

AMERICAN JOURNAL OF PHYSIOLOGY-ENDOCRINOLOGY AND METABOLISM (2014)

Article Endocrinology & Metabolism

Circulating FGF21 Is Liver Derived and Enhances Glucose Uptake During Refeeding and Overfeeding

Kathleen R. Markan et al.

DIABETES (2014)

Review Veterinary Sciences

Fasting of mice: a review

T. L. Jensen et al.

LABORATORY ANIMALS (2013)

Article Cell Biology

FGF21 regulates PGC-1α and browning of white adipose tissues in adaptive thermogenesis

Ffolliott M. Fisher et al.

GENES & DEVELOPMENT (2012)

Article Multidisciplinary Sciences

mTORC1 controls fasting-induced ketogenesis and its modulation by ageing

Shomit Sengupta et al.

NATURE (2010)

Article Biochemistry & Molecular Biology

Identification of a Physiologically Relevant Endogenous Ligand for PPARα in Liver

Manu V. Chakravarthy et al.

Article Biochemistry & Molecular Biology

Peroxisome Proliferator-Activated Receptor β/δ (PPARβ/δ) but Not PPARα Serves as a Plasma Free Fatty Acid Sensor in Liver

Linda M. Sanderson et al.

MOLECULAR AND CELLULAR BIOLOGY (2009)

Article Biochemistry & Molecular Biology

Amplification efficiency: linking baseline and bias in the analysis of quantitative PCR data

J. M. Ruijter et al.

NUCLEIC ACIDS RESEARCH (2009)