4.8 Article

A VQ-motif-containing protein fine-tunes rice immunity and growth by a hierarchical regulatory mechanism

期刊

CELL REPORTS
卷 40, 期 7, 页码 -

出版社

CELL PRESS
DOI: 10.1016/j.celrep.2022.111235

关键词

-

资金

  1. National Natural Science Foundation of China [32161143009, 31822041, 31972225, U20A2021]
  2. Major Research Plan of the National Natural Science Foundation of China [3218810004]

向作者/读者索取更多资源

A ubiquitin E3 ligase-VQ protein-transcription factor module has been discovered to fine-tune plant immunity and growth by regulating gene expression at the transcriptional and posttranslational levels.
Rice blast and bacterial blight, caused by the fungus Magnaporthe oryzae and the bacterium Xanthomonas oryzae pv. oryzae (Xoo), respectively, are devastating diseases affecting rice. Here, we report that a rice valine-glutamine (VQ) motif-containing protein, OsVQ25, balances broad-spectrum disease resistance and plant growth by interacting with a U-Box E3 ligase, OsPUB73, and a transcription factor, OsWRKY53. We show that OsPUB73 positively regulates rice resistance against M. oryzae and Xoo by interacting with and promoting OsVQ25 degradation via the 26S proteasome pathway. Knockout mutants of OsVQ25 exhibit enhanced resistance to both pathogens without a growth penalty. Furthermore, OsVQ25 interacts with and suppresses the transcriptional activity of OsWRKY53, a positive regulator of plant immunity. OsWRKY53 downstream defense-related genes and brassinosteroid signaling genes are upregulated in osvq25 mutants. Our findings reveal a ubiquitin E3 ligase-VQ protein-transcription factor module that fine-tunes plant immunity and growth at the transcriptional and posttranslational levels.

作者

我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。

评论

主要评分

4.8
评分不足

次要评分

新颖性
-
重要性
-
科学严谨性
-
评价这篇论文

推荐

暂无数据
暂无数据