Long-term functioning status of COVID-19 survivors: a prospective observational evaluation of a cohort of patients surviving hospitalisation

Article Immunology

Trends in Clinical Severity of Hospitalized Patients With Coronavirus Disease 2019 Premier Hospital Dataset, April 2020-April 2021

Geoffrey P. Whitfield et al.

Summary: The clinical severity of hospitalized COVID-19 patients has varied over time but has not consistently or significantly worsened. The proportion of admissions classified as grade 4 decreased in all subgroups.

OPEN FORUM INFECTIOUS DISEASES (2022)

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Article Infectious Diseases

Clinical sequelae of COVID-19 survivors in Wuhan, China: a single-centre longitudinal study

Qiutang Xiong et al.

Summary: The study described the common clinical sequelae in COVID-19 survivors discharged from the hospital for more than 3 months, including general symptoms, respiratory symptoms, cardiovascular-related symptoms, psychosocial symptoms, and alopecia. Female patients were more likely to experience physical decline/fatigue, postactivity polypnoea, and alopecia.

CLINICAL MICROBIOLOGY AND INFECTION (2021)

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Article Immunology

Long COVID in the Faroe Islands: A Longitudinal Study Among Nonhospitalized Patients

Maria Skaalum Petersen et al.

Summary: The study showed that over half of COVID-19 patients still had at least one symptom persisting after an average of 125 days post-symptom onset, with fatigue, loss of smell and taste, and arthralgias being the most prevalent persistent symptoms. At the last follow-up, 46.9% of patients were asymptomatic compared to only 4.4% during the acute phase. Continued monitoring for long COVID is necessary.

CLINICAL INFECTIOUS DISEASES (2021)

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Article Medicine, General & Internal

6-month consequences of COVID-19 in patients discharged from hospital: a cohort study (Publication with Expression of Concern. See vol. 401, pg. 90, 2023)

Chaolin Huang et al.

Summary: This study aimed to investigate the long-term health consequences of discharged COVID-19 patients and associated risk factors, particularly disease severity. Patients with more severe illness during hospitalization showed more severe impaired pulmonary diffusion capacities and abnormal chest imaging manifestations, highlighting the need for targeted interventions for long-term recovery.

LANCET (2021)

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Article Geriatrics & Gerontology

Muscles adaptation to aging and training: architectural changes - a randomised trial

Adrien J. Letocart et al.

Summary: The study found that muscle loss with aging is region-specific for some muscles and uniform for others. Equivalent strength training volume at moderate or high intensities increased muscle volume with no differences in muscle volume gains for old men. These data suggest that physical exercise at moderate intensity (55 to 60% of one repetition maximum) can reverse the aging related loss of muscle mass.

BMC GERIATRICS (2021)

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Article Medicine, General & Internal

Respiratory and Psychophysical Sequelae Among Patients With COVID-19 Four Months After Hospital Discharge

Mattia Bellan et al.

Summary: The study examined the prevalence of lung function, exercise function, and psychological sequelae among survivors of severe COVID-19 four months after discharge. Over half of patients experienced reduced lung capacity, one-fifth had functional impairment, and about one-fifth showed symptoms of posttraumatic stress. These findings suggest that a significant proportion of COVID-19 survivors may continue to experience respiratory, functional, or psychological issues months after hospital discharge.

JAMA NETWORK OPEN (2021)

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Article Critical Care Medicine

Pulmonary Function and Radiologic Features in Survivors of Critical COVID-19 A 3-Month Prospective Cohort

Jessica Gonzalez et al.

Summary: The study investigated the long-term pulmonary sequelae in critical patients who survived COVID-19, finding that structural abnormalities and functional impairment were highly prevalent in these patients three months after discharge, indicating the need for pulmonary evaluation in all critical COVID-19 survivors.

CHEST (2021)

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Article Respiratory System

Medium-term impact of COVID-19 on pulmonary function, functional capacity and quality of life

Fabio Anastasio et al.

Summary: This study evaluated the mid-term clinical impact of COVID-19 on respiratory function in 379 patients, finding that lung damage during acute infection correlates with the reduction in pulmonary function.

EUROPEAN RESPIRATORY JOURNAL (2021)

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Article Rehabilitation

Midterm functional sequelae and implications in rehabilitation after COVID-19: a cross-sectional study

Alessio BARICICH et al.

European Journal of Physical and Rehabilitation Medicine (2021)

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Article Orthopedics

Cardiopulmonary Exercise Testing to Assess Persistent Symptoms at 6 Months in People With COVID-19 Who Survived Hospitalization: A Pilot Study

David Debeaumont et al.

Summary: The aim of this pilot study is to evaluate physical fitness and its correlation with functional dyspnea in COVID-19 survivors 6 months post-discharge. Results show that persistent dyspnea is associated with reduced physical fitness, with differences between ICU and general ward patients. Tailored rehabilitation interventions may be beneficial for those with persistent dyspnea.

PHYSICAL THERAPY (2021)

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Article Medicine, General & Internal

Association Between Caseload Surge and COVID-19 Survival in 558 US Hospitals, March to August 2020

Sameer S. Kadri et al.

Summary: A retrospective cohort study conducted on COVID-19 patients from 558 U.S. hospitals between March and August 2020 found a significant increase in COVID-19 mortality rate with higher surge index percentiles, with the highest mortality rate observed in the 99th percentile and above. The study also revealed that despite increased use of corticosteroids and more judicious intubation in later months, the surge-mortality relationship was stronger in June to August compared to March to May.

ANNALS OF INTERNAL MEDICINE (2021)

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Article Rehabilitation

Assessment of musculoskeletal pain, fatigue and grip strength in hospitalized patients with COVID-19

Sansin Tuzun et al.

Summary: Musculoskeletal symptoms are common in COVID-19 patients, with severe ischemic myalgia regardless of disease activity. Muscle weakness is more prominent in women with lower grip strength, and should be considered in rehabilitation strategies for COVID-19 patients.

EUROPEAN JOURNAL OF PHYSICAL AND REHABILITATION MEDICINE (2021)

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Article Medicine, General & Internal

Post-acute sequelae of SARS-CoV-2 infection (PASC): a protocol for a multidisciplinary prospective observational evaluation of a cohort of patients surviving hospitalisation in Sao Paulo, Brazil

Geraldo Filho Busatto et al.

Summary: This study aims to prospectively observe over 3000 surviving COVID-19 inpatients through multidisciplinary assessments at 6-9 months and 12-15 months post-discharge. It seeks to provide insights into the frequency and severity of chronic/post-COVID multiorgan symptoms, as well as their interrelationships with acute disease features, sociodemographic variables, and environmental exposures. The findings will be disseminated in peer-reviewed journals and scientific meetings, with a data repository for future pathophysiological investigations using biomarker data.

BMJ OPEN (2021)

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Article Medicine, General & Internal

Rehabilitation of patients after COVID-19 recovery: An experience at the Physical and Rehabilitation Medicine Institute and Lucy Montoro Rehabilitation Institute

Marta Imamura et al.

Summary: Rehabilitation treatment for patients recovering from COVID-19 significantly improves their functional status, especially in terms of Functional Independence Measure (FIM) improvement and increase in lean mass. The length of inpatient rehabilitation treatment is closely related to improvements in FIM scores and gains in lean mass.

CLINICS (2021)

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Review Geriatrics & Gerontology