期刊
ADVANCED HEALTHCARE MATERIALS
卷 11, 期 18, 页码 -出版社
WILEY
DOI: 10.1002/adhm.202200939
关键词
bioadhesives; hemostatic; human blood; liver and heart; plant-derived okra gel; rabbit and dog model
资金
- Chongqing Science and Health Joint Medical Research Project [2020MSXM127]
- Natural Science and Engineering Research Council of Canada (NSERC) Discovery grant
This article reports a sustainable and robust hemostatic bioadhesive from okra. The bioadhesive shows excellent adhesive strength and underwater adhesion, providing quick hemostasis and promoting wound healing.
Bioadhesive performance can be compromised due to bleeding. Bleeding increases mortality. Adhesives with hemostatic function are of great significance. A sustainable and robust hemostatic bioadhesive from okra is reported. The adhesive strength reaches around three and six-fold higher than commercial fibrin on pigskin and glass, respectively. The okra gel presents high-pressure resistance and great underwater adhesive strength. In human blood experiments, the okra gel can activate platelets, enhance the adhesion of activated platelets, and release coagulation factors XI and XII. By forming a fast gel layer and closely adhering to the wound, it can quickly stop bleeding in the liver and heart of rabbits and dogs. Meanwhile, okra gel can cause platelet activation at the wound site and further strengthen its hemostatic performance. It is biocompatible, biodegradable, and can promote wound healing and shows potential as a sustainable bioadhesive, especially in the scenario of significant hemorrhage.
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