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Extracellular Vesicle Mimetics: Preparation from Top-Down Approaches and Biological Functions

ADVANCED HEALTHCARE MATERIALS (2022)

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Vesicle Induced Receptor Sequestration: Mechanisms behind Extracellular Vesicle-Based Protein Signaling

Oskar Staufer et al.

Summary: Extracellular vesicles (EVs) play a fundamental role in the proper physiological functioning of multicellular organisms by shuttling nucleic acids and proteins between cells to regulate a plethora of cellular processes, especially immune signalling. In this study, the authors investigate vesicle-induced receptor sequestration (VIRS) as a universal mechanism that enhances the signalling potency of proteins presented on EV membranes. They propose that vesicle-triggered local clustering of membrane receptors is the principle structural mechanism underlying EV-based protein presentation.

ADVANCED SCIENCE (2022)

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Review Biotechnology & Applied Microbiology

Can Bottom-Up Synthetic Biology Generate Advanced Drug-Delivery Systems?

Felix Lussier et al.

Summary: This article discusses the use of novel modular manufacturing approaches, combined with bottom-up synthetic biology principles and microfluidics, to construct programmable drug carriers in order to overcome some fundamental limitations of nanomedicine.

TRENDS IN BIOTECHNOLOGY (2021)

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Article Pharmacology & Pharmacy

Preservation of small extracellular vesicles for functional analysis and therapeutic applications: a comparative evaluation of storage conditions

Jun-Yong Wu et al.

Summary: Storage temperature and duration significantly impact the stability of sEVs, leading to changes in size distribution, quantity, contents, cellular uptake, and biodistribution. It is suggested to choose the appropriate storage temperature based on the requirements of the study.

DRUG DELIVERY (2021)

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Article Chemistry, Physical

Dual Ion Releasing Nanoparticles for Modulating Osteogenic Cellular Microenvironment of Human Mesenchymal Stem Cells

Yu-Jin Kim et al.

Summary: In this study, a dual therapeutic metal ion-releasing nanoparticle was developed to enhance osteogenic differentiation of stem cells and induce angiogenesis. Zinc and iron were synthesized together into a nanoparticle with a pH-sensitive degradation property to promote osteogenic gene expression and angiogenic factor secretion for human mesenchymal stem cells.

MATERIALS (2021)

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Article Cell & Tissue Engineering

Local delivery of USC-derived exosomes harboring ANGPTL3 enhances spinal cord functional recovery after injury by promoting angiogenesis

Yong Cao et al.

Summary: In this study, it was demonstrated that a locally administered injection of USC-Exo embedded in hydrogel can deliver ANGPTL3 to the injured spinal cord region. Additionally, the administration of human USC-Exo could enhance spinal cord neurological functional recovery by promoting angiogenesis. Mechanistic studies revealed that ANGPTL3 enriched in USC-Exo is required for their ability to promote angiogenesis through the PI3K/AKT signaling pathway.

STEM CELL RESEARCH & THERAPY (2021)

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Article Biotechnology & Applied Microbiology

Neural progenitor cell-derived nanovesicles promote hair follicle growth via miR-100

Lei Cao et al.

Summary: The study found that ReN-NV promotes DPC proliferation and accelerates HF cycling transition in a mouse model. This acceleration is achieved through the activation of the Wnt/beta-catenin signaling pathway.

JOURNAL OF NANOBIOTECHNOLOGY (2021)

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Review Engineering, Biomedical

Extracellular vesicles: A bright star of nanomedicine

Peipei Wu et al.

Summary: Extracellular vesicles play a crucial role in disease treatment and diagnosis, with engineered design enhancing their therapeutic capability and diagnostic imaging potential.

BIOMATERIALS (2021)

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Article Chemistry, Multidisciplinary

Engineering exosomes for pulmonary delivery of peptides and drugs to inflammatory lung cells by inhalation

GyeungYun Kim et al.

Summary: Exosomes engineered for pulmonary delivery of RAGE-binding peptide (RBP) showed enhanced anti-inflammatory effects, especially when curcumin was loaded into the exosomes. These findings suggest that RBP-exo/Cur may serve as a promising therapy for acute lung injury.

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Article Engineering, Biomedical

Clodronate-loaded liposomal and fibroblast-derived exosomal hybrid system for enhanced drug delivery to pulmonary fibrosis

Lingna Sun et al.

Summary: A clodronate-loaded liposome and fibroblast-derived exosome hybrid drug delivery system, named EL-CLD, was designed for the treatment of pulmonary fibrosis. This system effectively targeted fibrotic lung tissue by homing to fibroblasts and showed enhanced therapeutic efficacy compared to traditional drug delivery methods. The EL-CLD system acted as an efficient carrier for anti-fibrotic drugs, improving tissue accumulation and delivery while reducing inflammatory responses.

BIOMATERIALS (2021)

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Article Chemistry, Multidisciplinary

Nanoghosts: Mesenchymal Stem cells derived nanoparticles as a unique approach for cartilage regeneration

D. D'Atri et al.

Summary: Osteoarthritis is a chronic degenerative disease with no current treatment options, but cell-membrane-based nanoparticles and mesenchymal stem cells are being studied as promising new approaches. Research demonstrates the potential of nano-ghosts system in targeting cartilage tissues and modulating inflammatory processes.

JOURNAL OF CONTROLLED RELEASE (2021)

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Review Chemistry, Analytical

Exosomes as Powerful Engines in Cancer: Isolation, Characterization and Detection Techniques

Marwa Gamal Saad et al.

Summary: Exosomes are powerful extracellular nanovesicles released from living cells, serving as communication engines that control and reprogram physiological pathways. They are biomarkers for diseases and have potential in cancer treatment. Research on exosomes aims to relate biomarkers to origins and evaluate technologies for therapeutic purposes.

BIOSENSORS-BASEL (2021)

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Article Cell & Tissue Engineering

Combined topical and systemic administration with human adipose-derived mesenchymal stem cells (hADSC) and hADSC-derived exosomes markedly promoted cutaneous wound healing and regeneration

Yang Zhou et al.

Summary: This study investigated the potential clinical application roles of human adipose-derived mesenchymal stem cells (hADSC) and hADSC-derived exosomes (hADSC-Exo) in cutaneous wound healing. The combined administration of local hADSC-Exo smearing and hADSC/hADSC-Exo intravenous administration showed additional benefits in promoting wound healing, accelerating re-epithelialization, reducing scar widths, and enhancing angiogenesis and collagen synthesis.

STEM CELL RESEARCH & THERAPY (2021)

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Review Engineering, Biomedical

Targeted extracellular vesicle delivery systems employing superparamagnetic iron oxide nanoparticles

Zewei Zhuo et al.

Summary: In recent years, targeted extracellular vesicle (EV) delivery systems engineered by superparamagnetic iron oxide nanoparticles (SPIONs) have gained widespread attention and research interest. These strategies utilize external magnetic fields to manipulate SPION-functionalized EVs remotely in order to enhance their accumulation and penetration in vivo. However, the current controversy surrounding iron oxide nanoparticle laden EVs hinders their clinical application progress, calling for a comprehensive integration of studies for advanced insight and rational design of targeted EV delivery systems.

ACTA BIOMATERIALIA (2021)

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Review Pharmacology & Pharmacy

Technological advances towards extracellular vesicles mass production

Alice Grangier et al.

Summary: Extracellular vesicles (EVs) play essential roles in bio-therapeutics as both therapeutic agents and cargo delivery vehicles. Challenges remain in achieving large-scale production to reduce treatment costs, and current research is focused on developing high-yield manufacturing methods through platforms like large-scale cell cultures and cell stimulation techniques.

ADVANCED DRUG DELIVERY REVIEWS (2021)

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Review Pharmacology & Pharmacy

Illuminating RNA trafficking and functional delivery by extracellular vesicles

Willemijn S. de Voogt et al.

Summary: This article discusses the potential of RNA-based therapeutics and the characteristics of extracellular vesicles as delivery agents, emphasizing the importance of improving understanding of EV-RNA trafficking mechanisms.

ADVANCED DRUG DELIVERY REVIEWS (2021)

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Article Engineering, Biomedical

Gene-engineered exosomes-thermosensitive liposomes hybrid nanovesicles by the blockade of CD47 signal for combined photothermal therapy and cancer immunotherapy

Lili Cheng et al.

Summary: The designed hybrid therapeutic nanovesicles, hGLV, based on CD47 immune checkpoint blockade demonstrated long blood circulation, improved macrophage-mediated phagocytosis of tumor cells by blocking CD47 signal, targeted homologous tumors in mice effectively for preferential accumulation at tumor sites. Furthermore, hGLV loaded with photothermal agent achieved excellent photothermal therapy (PTT) in eliminating tumors, inducing immunogenic cell death, generating tumor-associated antigens, and promoting immune responses with the help of co-encapsulated immune adjuvant. Such hybrid nanovesicles show promise in drug delivery for cancer treatment.

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Urinary exosomes-based Engineered Nanovectors for Homologously Targeted Chemo-Chemodynamic Prostate Cancer Therapy via abrogating EGFR/AKT/NF-kB/IkB signaling

Shaojun Pan et al.

Summary: The utilization of urinary exosomes as nanovectors for homologous prostate cancer therapy shows promising results in targeted treatment and signal pathway inhibition, offering a potential solution for mass production of such nanovectors in the future.

BIOMATERIALS (2021)

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Review Chemistry, Multidisciplinary

Lipids and Lipid Derivatives for RNA Delivery

Yuebao Zhang et al.

Summary: RNA-based therapeutics have shown great promise in treating diseases through various mechanisms, with lipid nanoparticles being the most widely used delivery system. The study of lipids, lipid derivatives, and lipid-derived macromolecules for RNA delivery has also made significant progress in recent years.

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Exosomes and biomimetic nanovesicles-mediated anti-glioblastoma therapy: A head-to-head comparison

Jun-Yong Wu et al.

Summary: The study compared Exos and BNVs for brain tumor drug delivery, finding that BNVs derived from brain-derived endothelial cells are a promising alternative with higher yield and similar drug-loading capacity to natural exosomes. Despite different mechanisms, BNV/DOX showed similar therapeutic effects to Exo/DOX in inhibiting the progression of glioblastoma, with minimal systemic toxicity. The findings suggest that autologous BNVs are an effective alternative to Exos for brain tumor nanomedicine.

JOURNAL OF CONTROLLED RELEASE (2021)

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Review Neurosciences

Extracellular vesicles in the treatment of neurological disorders

Samantha L. Reed et al.

Summary: Extracellular vesicles (EVs) are cell-derived membranous particles that contain various molecules and play important roles in intercellular communication. They have shown efficacy in models of neurological disorders by reducing symptoms and providing benefits, making them a promising avenue for future research and clinical applications.

NEUROBIOLOGY OF DISEASE (2021)

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Article Cell Biology

Immunotherapy Using Oxygenated Water and Tumor-Derived Exosomes Potentiates Antitumor Immune Response and Attenuates Malignancy Tendency in Mice Model of Breast Cancer

Nafiseh Pakravan et al.

Summary: Breast cancer is a common and challenging disease, but combining oxygenated water and tumor-derived exosomes shows promise in reducing tumor size and optimizing anti-tumor immune responses.

OXIDATIVE MEDICINE AND CELLULAR LONGEVITY (2021)

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Article Infectious Diseases

Efficacy and safety of the CVnCoV SARS-CoV-2 mRNA vaccine candidate in ten countries in Europe and Latin America (HERALD): a randomised, observer-blinded, placebo-controlled, phase 2b/3 trial

Peter G Kremsner et al.

LANCET INFECTIOUS DISEASES (2021)

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Article Cell Biology

Retinoblastoma cell-derived exosomes promote angiogenesis of human vesicle endothelial cells through microRNA-92a-3p

Shuilian Chen et al.

Summary: Exosomes derived from retinoblastoma cells were found to enhance tumor angiogenesis, potentially through the action of miR-92a-3p. This suggests that exosomal miR-92a-3p could be a promising therapeutic candidate for retinoblastoma treatment.

CELL DEATH & DISEASE (2021)

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Review Biotechnology & Applied Microbiology

Artificial exosomes for translational nanomedicine

Yong-Jiang Li et al.

Summary: Artificial exosomes, produced through nanobiotechnology, have emerged as effective drug delivery carriers and include various types such as nanovesicles, exosome-mimetic, and hybrid exosomes. These artificial exosomes offer solutions to overcome limitations of natural exosomes and are considered powerful alternatives for drug delivery.

JOURNAL OF NANOBIOTECHNOLOGY (2021)

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Article Multidisciplinary Sciences

Bottom-up assembly of biomedical relevant fully synthetic extracellular vesicles

Oskar Staufer et al.

Summary: Extracellular vesicles play a crucial role in intercellular communication and cell physiology, but quantitative knowledge on their signaling mechanisms is lacking, hampering their therapeutic applications. By using a synthetic approach, researchers have shown that synthetic EVs have functionalities similar to natural EVs and can be used for therapeutic purposes in wound healing and neovascularization. Transcriptome profiling has enabled a systematic decoding of synergistic effects between individual EV constituents, leading to a better understanding of EV signaling.

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An integrated magneto-electrochemical device for the rapid profiling of tumour extracellular vesicles from blood plasma

Jongmin Park et al.

Summary: The device described in the study efficiently integrates enrichment and electrochemical detection of tumor extracellular vesicles, accurately classifying colorectal cancer patients in less than an hour. The device showed high accuracy in classifying patients, with potential for aiding in cancer detection and monitoring.

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Preclinical efficacy and clinical safety of clinical-grade nebulized allogenic adipose mesenchymal stromal cells-derived extracellular vesicles

Meng-Meng Shi et al.

Summary: MSC-EVs derived from mesenchymal stromal cells have shown promise as a cell-free therapy source. Nebulized haMSC-EVs improved survival rates and lung inflammation in a murine lung injury model, and were well tolerated in healthy volunteers. These findings suggest that nebulized haMSC-EVs could be a promising therapeutic strategy for lung injury diseases.

JOURNAL OF EXTRACELLULAR VESICLES (2021)

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Article Materials Science, Biomaterials

Exosomes from human cord blood plasma accelerate cutaneous wound healing by promoting fibroblast function, angiogenesis, and M2 macrophage differentiation

Sueon Kim et al.

Summary: Exosomes are important in transferring natural cargo molecules to neighboring or distant cells, playing a crucial role in wound healing. The study of wound healing potential of proteins in human cord blood plasma exosomes revealed that they have better wound healing effects compared to adult blood plasma exosomes. The use of artificial CBPexo may potentially overcome limitations related to exosome production from cord blood.

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Review Medicine, Research & Experimental

Engineering exosomes for targeted drug delivery

Yujie Liang et al.

Summary: Exosomes can be engineered through genetic and chemical methods for targeted drug delivery, increasing the local concentration of therapeutics and minimizing side effects.

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Engineered extracellular vesicles with synthetic lipids via membrane fusion to establish efficient gene delivery

Yong-Yu Jhan et al.

INTERNATIONAL JOURNAL OF PHARMACEUTICS (2020)

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Ye Tian et al.

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White blood cell labeling with Technetium-99m (99mTc) using red blood cell extracellular vesicles-mimetics

Seung Hyun Son et al.

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Attenuation of Tumor Necrosis Factor-α Induced Inflammation by Umbilical Cord-Mesenchymal Stem Cell Derived Exosome-Mimetic Nanovesicles in Endothelial Cells

Kyoung-Won Ko et al.

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Gaofeng Liang et al.

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Exosome Derived from Coronary Serum of Patients with Myocardial Infarction Promotes Angiogenesis Through the miRNA-143/IGF-IR Pathway

Tao Geng et al.

INTERNATIONAL JOURNAL OF NANOMEDICINE (2020)

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Exosomes Derived from Bone Marrow Mesenchymal Stem Cells as Treatment for Severe COVID-19

Vikram Sengupta et al.

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Nanovesicles derived from iron oxide nanoparticles-incorporated mesenchymal stem cells for cardiac repair

Ju-Ro Lee et al.

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Thermosensitive Exosome-Liposome Hybrid Nanoparticle-Mediated Chemoimmunotherapy for Improved Treatment of Metastatic Peritoneal Cancer

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Development of Artificial Plasma Membranes Derived Nanovesicles Suitable for Drugs Encapsulation

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Non-coding RNAs shuttled via exosomes reshape the hypoxic tumor microenvironment

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Osteocyte-derived exosomes induced by mechanical strain promote human periodontal ligament stem cell proliferation and osteogenic differentiation via the miR-181b-5p/PTEN/AKT signaling pathway

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Tumor cell-derived exosomes home to their cells of origin and can be used as Trojan horses to deliver cancer drugs

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Extracellular Vesicles as Drug Delivery Systems - Methods of Production and Potential Therapeutic Applications

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Cytochalasin-B-Inducible Nanovesicle Mimics of Natural Extracellular Vesicles That Are Capable of Nucleic Acid Transfer

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Exosome-like Nanozyme Vesicles for H2O2-Responsive Catalytic Photoacoustic Imaging of Xenograft Nasopharyngeal Carcinoma

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Utility of Neuronal-Derived Exosomes to Examine Molecular Mechanisms That Affect Motor Function in Patients With Parkinson Disease A Secondary Analysis of the Exenatide-PD Trial

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Embryonic stem cell-derived extracellular vesicle-mimetic nanovesicles rescue erectile function by enhancing penile neurovascular regeneration in the streptozotocin-induced diabetic mouse

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Tetraspanin-decorated extracellular vesicle-mimetics as a novel adaptable reference material

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Aptamer-functionalized exosomes from bone marrow stromal cells target bone to promote bone regeneration

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Exosomes from nicotine-stimulated macrophages accelerate atherosclerosis through miR-21-3p/PTEN-mediated VSMC migration and proliferation

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Extracellular vesicle-mimetic nanovesicles transport LncRNA-H19 as competing endogenous RNA for the treatment of diabetic wounds

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Patisiran, an RNAi Therapeutic, for Hereditary Transthyretin Amyloidosis

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Exosome-Mimetic Nanovesicles from Hepatocytes promote hepatocyte proliferation in vitro and liver regeneration in vivo

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Exosome-Liposome Hybrid Nanoparticles Deliver CRISPR/Cas9 System in MSCs

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Human Mesenchymal Stem Cell Derived Exosomes Alleviate Type 2 Diabetes Mellitus by Reversing Peripheral Insulin Resistance and Relieving β-Cell Destruction

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Review Biochemistry & Molecular Biology

The Methods of Choice for Extracellular Vesicles (EVs) Characterization

Rafal Szatanek et al.

INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES (2017)

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Review Cell Biology

Extracellular vesicle mimetics: Novel alternatives to extracellular vesicle-based theranostics, drug delivery, and vaccines

Oh Youn Kim et al.

SEMINARS IN CELL & DEVELOPMENTAL BIOLOGY (2017)

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Article Engineering, Biomedical

Cell-Engineered Nanovesicle as a Surrogate Inducer of Contact-Dependent Stimuli

Junho Kim et al.

ADVANCED HEALTHCARE MATERIALS (2017)

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Review Cell & Tissue Engineering

Concise Review: Developing Best-Practice Models for the Therapeutic Use of Extracellular Vesicles

Agnes T. Reiner et al.

STEM CELLS TRANSLATIONAL MEDICINE (2017)

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Article Multidisciplinary Sciences

Bioinspired Cell-Derived Nanovesicles versus Exosomes as Drug Delivery Systems: a Cost-Effective Alternative

Wei Jiang Goh et al.

SCIENTIFIC REPORTS (2017)

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Review Chemistry, Multidisciplinary

Cellular uptake of nanoparticles: journey inside the cell

Shahed Behzadi et al.

CHEMICAL SOCIETY REVIEWS (2017)

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Article Cell Biology

Comprehensive toxicity and immunogenicity studies reveal minimal effects in mice following sustained dosing of extracellular vesicles derived from HEK293T cells

Xiaohua Zhu et al.

JOURNAL OF EXTRACELLULAR VESICLES (2017)

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Article Biochemistry & Molecular Biology

Adipose stem cell-derived nanovesicles inhibit emphysema primarily via an FGF2-dependent pathway

You-Sun Kim et al.

EXPERIMENTAL AND MOLECULAR MEDICINE (2017)

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Review Pharmacology & Pharmacy

Extracellular vesicles for drug delivery

Pieter Vader et al.

ADVANCED DRUG DELIVERY REVIEWS (2016)

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Article Engineering, Biomedical

RNAi delivery by exosome-mimetic nanovesicles - Implications for targeting c-Myc in cancer

Taral R. Lunavat et al.

BIOMATERIALS (2016)

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Article Chemistry, Multidisciplinary

Nanoghosts as a Novel Natural Nonviral Gene Delivery Platform Safely Targeting Multiple Cancers

Limor Kaneti et al.

NANO LETTERS (2016)

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Article Chemistry, Multidisciplinary

Monocyte cell membrane-derived nanoghosts for targeted cancer therapy

S. Krishnamurthy et al.

NANOSCALE (2016)

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Article Multidisciplinary Sciences

Engineering hybrid exosomes by membrane fusion with liposomes

Yuko T. Sato et al.

SCIENTIFIC REPORTS (2016)

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Article Multidisciplinary Sciences

Liposome production by microfluidics: potential and limiting factors

Dario Carugo et al.

SCIENTIFIC REPORTS (2016)

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Article Cell Biology

Techniques used for the isolation and characterization of extracellular vesicles: results of a worldwide survey

Chris Gardiner et al.

JOURNAL OF EXTRACELLULAR VESICLES (2016)

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Article Chemistry, Multidisciplinary

In Vivo Differentiation of Therapeutic Insulin-Producing Cells from Bone Marrow Cells via Extracellular Vesicle-Mimetic Nanovesicles

Keunhee Oh et al.

ACS NANO (2015)

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Article Engineering, Biomedical

Generation of nanovesicles with sliced cellular membrane fragments for exogenous material delivery

Jaewoong Yoon et al.

BIOMATERIALS (2015)

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Article Multidisciplinary Sciences

Noninvasive imaging of radiolabeled exosome-mimetic nanovesicle using 99mTc-HMPAO

Do Won Hwang et al.

SCIENTIFIC REPORTS (2015)

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Article Chemistry, Multidisciplinary

Bacterial Protoplast-Derived Nanovesicles as Vaccine Delivery System against Bacterial Infection

Oh Youn Kim et al.

NANO LETTERS (2015)

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Article Cell Biology

Applying extracellular vesicles based therapeutics in clinical trials - an ISEV position paper

Thomas Lener et al.

JOURNAL OF EXTRACELLULAR VESICLES (2015)

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Article Engineering, Biomedical

Nanovesicles engineered from ES cells for enhanced cell proliferation

Dayeong Jeong et al.

BIOMATERIALS (2014)

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Article Hematology

Particle size distribution of exosomes and microvesicles determined by transmission electron microscopy, flow cytometry, nanoparticle tracking analysis, and resistive pulse sensing

E. van der Pol et al.

JOURNAL OF THROMBOSIS AND HAEMOSTASIS (2014)

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Article Biochemical Research Methods

Microfluidic fabrication of cell-derived nanovesicles as endogenous RNA carriers

Wonju Jo et al.

LAB ON A CHIP (2014)

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Article Chemistry, Multidisciplinary

Large-scale generation of cell-derived nanovesicles

W. Jo et al.

NANOSCALE (2014)

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Review Oncology

Harnessing the exosome-induced immune response for cancer immunotherapy

Ulf Gehrmann et al.

SEMINARS IN CANCER BIOLOGY (2014)

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Review Cell Biology

Routes and mechanisms of extracellular vesicle uptake

Laura Ann Mulcahy et al.

JOURNAL OF EXTRACELLULAR VESICLES (2014)

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Article Cell Biology

Reproducible extracellular vesicle size and concentration determination with tunable resistive pulse sensing

Frank A. W. Coumans et al.

JOURNAL OF EXTRACELLULAR VESICLES (2014)

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Article Chemistry, Multidisciplinary

Bioinspired Exosome-Mimetic Nanovesicles for Targeted Delivery of Chemotherapeutics to Malignant Tumors

Su Chul Jang et al.

ACS NANO (2013)

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Article Biochemistry & Molecular Biology

Tetraspanin CD63 Promotes Vascular Endothelial Growth Factor Receptor 2-β1 Integrin Complex Formation, Thereby Regulating Activation and Downstream Signaling in Endothelial Cells in Vitro and in Vivo

Sonia Tugues et al.

JOURNAL OF BIOLOGICAL CHEMISTRY (2013)

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Article Chemistry, Multidisciplinary

Reconstructed Stem Cell Nanoghosts: A Natural Tumor Targeting Platform

Naama E. Toledano Furman et al.

NANO LETTERS (2013)

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Article Cell Biology

Standardization of sample collection, isolation and analysis methods in extracellular vesicle research

Kenneth W. Witwer et al.

JOURNAL OF EXTRACELLULAR VESICLES (2013)

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Article Medicine, Research & Experimental

Immunogenicity of different stressed IgG monoclonal antibody formulations in immune tolerant transgenic mice

Vasco Filipe et al.

MABS (2012)

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Article Cell Biology

Signaling Mechanisms Controlling Cell Fate and Embryonic Patterning

Norbert Perrimon et al.

COLD SPRING HARBOR PERSPECTIVES IN BIOLOGY (2012)

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Article Nanoscience & Nanotechnology

Sizing and phenotyping of cellular vesicles using Nanoparticle Tracking Analysis

Rebecca A. Dragovic et al.

NANOMEDICINE-NANOTECHNOLOGY BIOLOGY AND MEDICINE (2011)

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Article Multidisciplinary Sciences

The ground state of embryonic stem cell self-renewal

Qi-Long Ying et al.

NATURE (2008)

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Review Cell Biology

Blebs lead the way: how to migrate without lamellipodia

Guillaume Charras et al.

NATURE REVIEWS MOLECULAR CELL BIOLOGY (2008)

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Article Multidisciplinary Sciences

Non-equilibration of hydrostatic pressure in blebbing cells

GT Charras et al.

NATURE (2005)

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Article Chemistry, Multidisciplinary

Investigating cellular signaling reactions in single attoliter vesicles

H Pick et al.

JOURNAL OF THE AMERICAN CHEMICAL SOCIETY (2005)

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Review Biotechnology & Applied Microbiology

Recent advances with liposomes as pharmaceutical carriers

VP Torchilin

NATURE REVIEWS DRUG DISCOVERY (2005)

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Article Multidisciplinary Sciences

Identification and proteomic profiling of exosomes in human urine

T Pisitkun et al.

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2004)

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Article Immunology

Antigen-presenting cell exosomes are protected from complement-mediated lysis by expression of CD55 and CD59

A Clayton et al.

EUROPEAN JOURNAL OF IMMUNOLOGY (2003)

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Article Oncology

Reduced cardiotoxicity and preserved antitumor efficacy of liposome-encapsulated doxorubicin and cyclophosphamide compared with conventional doxorubicin and cyclophosphamide in a randomized, multicenter trial of metastatic breast cancer

G Batist et al.

JOURNAL OF CLINICAL ONCOLOGY (2001)

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