期刊
ADVANCED HEALTHCARE MATERIALS
卷 11, 期 19, 页码 -出版社
WILEY
DOI: 10.1002/adhm.202200142
关键词
biomaterials; drug delivery; extracellular vesicle mimetics; extracellular vesicles; productivity
资金
- National Natural Science Foundation of China [82072414]
- Key Research and Development Plan in Zhejiang Province [2020C03043, 2020C03041]
- Zhejiang Province Medical and Health Science and Technology Project-Provincial and Ministry Co-construction Major Project [WKJ-ZJ-1906]
- Public Projects of Zhejiang Province [LGF21H060005]
- Innovative Talent Support Program Project of Zhejiang Provincial Health Commission [2021433298]
- Wenzhou major science and technology project [2018ZY015]
- Hangzhou Qianjiang Distinguished Expert and Zhejiang Provincial Program
This article reviews the preparation of EV mimetics (EVMs) as alternatives to EVs using a top-down approach. EVMs possess similar structure and composition to EVs, and exhibit good targeting ability and cellular uptake mechanism. However, EVMs also have certain limitations and immunogenicity issues. Despite these drawbacks, EVMs show great potential for clinical applications.
Extracellular vesicles (EVs) have attracted attention as delivery vehicles due to their structure, composition, and unique properties in regeneration and immunomodulation. However, difficulties during production and isolation processes of EVs limit their large-scale clinical applications. EV mimetics (EVMs), prepared via top-down strategies that improve the yield of nanoparticles while retaining biological properties similar to those of EVs have been used to address these limitations. Herein, the preparation of EVMs is reviewed and their characteristics in terms of structure, composition, targeting ability, cellular uptake mechanism, and immunogenicity, as well as their strengths, limitations, and future clinical application prospects as EV alternatives are summarized.
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