4.7 Article

Spatiotemporal Regulation of Astaxanthin Synthesis in S. cerevisiae

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Targeting pathway expression to subcellular organelles improves astaxanthin synthesis in Yarrowia lipolytica

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Summary: This study explores the strategy of expressing the astaxanthin biosynthesis pathway in sub-organelles of the oleaginous yeast Yarrowia lipolytica to achieve efficient synthesis of astaxanthin, leading to increased yield and reduced accumulation of intermediates. Targeting the astaxanthin pathway to subcellular organelles accelerates conversion and significantly improves synthesis, ultimately enhancing compartmentalized isoprenoid biosynthesis in Y. lipolytica.

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