4.5 Article

Coinfection in the host can result in functional complementation between live vaccines and virulent virus

期刊

VIRULENCE
卷 13, 期 1, 页码 980-989

出版社

TAYLOR & FRANCIS INC
DOI: 10.1080/21505594.2022.2082645

关键词

complementation; vaccines; herpesvirus; Marek's disease; transmission

资金

  1. Agriculture and Food Research Initiative Competitive [2020-67015-21399]
  2. USDA National Institute of Food and Agriculture
  3. USDA-NIFA AFRI [2019-67015-29262]
  4. Research in Biomedicine and Agriculture Using Agriculturally Important Domestic Animal Species Program

向作者/读者索取更多资源

Functional complementation between vaccines and virulent viruses has been observed, suggesting it as a potential mechanism for vaccine-mediated viral evolution. This phenomenon should be considered during the development of novel vaccines.
One of the greatest achievements of the last century is the development of vaccines against viral diseases. Vaccines are essential for battling infectious diseases and many different formulations are available, including live attenuated vaccines. However, the use of live attenuated vaccines has the potential for adverse effects, including reversion of pathogenicity, recombination, and functional complementation in the host. Marek's disease is a serious disease in poultry controlled by live attenuated vaccines that has resulted in increased virulence over the decades. Recombination between circulating field viruses or vaccines is a proposed mechanism for the increase in virulence, however, complementation between vaccines and field strains has not been demonstrated in chickens. Here, we describe functional complementation of vaccines with virulent virus to functionally complement transmission and spread in the host. Using the natural virus-host model of Marek's disease in chickens, our results show dual infection of target cells in chickens with vaccine and virulent virus providing the opportunity for recombination or complementation to transpire. Interestingly, our controlled results showed no evidence of recombination between vaccine and virulent virus, but functional complementation occurred in two independent experiments providing proof for complementation during natural infection in vaccinated individuals. These results suggest complementation as a potential mechanism for vaccine-mediated viral evolution and the potential for complementation should be taken into consideration when developing novel vaccines.

作者

我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。

评论

主要评分

4.5
评分不足

次要评分

新颖性
-
重要性
-
科学严谨性
-
评价这篇论文

推荐

暂无数据
暂无数据