Topical administration of the secretome derived from human amniotic epithelial cells ameliorates psoriasis-like skin lesions in mice

Article Oncology

Effects of different concentrations of human umbilical cord mesenchymal stem cells to ameliorate psoriasis-like skin lesions in BALB/c mice

Youshu Lin et al.

Summary: The study found that human umbilical cord mesenchymal stem cells (hUC-MSCs) had a significant therapeutic effect on psoriasis in a mouse model. Higher concentrations of hUC-MSCs showed the best therapeutic effect.

ANNALS OF TRANSLATIONAL MEDICINE (2022)

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Article Cell Biology

Human umbilical cord-derived mesenchymal stem cells ameliorate psoriasis-like dermatitis by suppressing IL-17-producing γδ T cells

Youdong Chen et al.

Summary: Studies have shown that human umbilical cord-derived MSCs (hUC-MSCs) have the potential to effectively treat psoriasis due to their immunomodulatory capability. Subcutaneous injection of 2 million hUC-MSCs was identified as the optimal therapeutic strategy. Furthermore, hUC-MSCs may suppress skin inflammation by inhibiting interleukin-17-producing gamma delta T cells.

CELL AND TISSUE RESEARCH (2022)

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Review Biochemistry & Molecular Biology

Skin Barrier Dysregulation in Psoriasis

Andreas Orsmond et al.

Summary: The skin barrier consists of a physical barrier in the epidermis and an immune barrier in both dermis and epidermis, which cooperate to maintain skin homeostasis and human health. Dysregulation can lead to various skin diseases, with psoriasis being one of the most prevalent due to disrupted barrier function. Recent research has focused on understanding disease pathogenesis involving keratinocytes, immune cells, genetic and environmental factors, and advancements in current and future treatments.

INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES (2021)

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Article Immunology

Conditioned Medium of Human Amniotic Epithelial Cells Alleviates Experimental Allergic Conjunctivitis Mainly by IL-1ra and IL-10

Binxin Wu et al.

Summary: The study found that human amniotic epithelial cell-conditioned medium (AECM) significantly alleviated symptoms of allergic conjunctivitis, reduced infiltration of immune cells and levels of inflammatory factors in the conjunctiva, and increased levels of anti-inflammatory factors IL-1 receptor antagonist (IL-1ra) and IL-10. The anti-allergic effects of AECM were mainly mediated by IL-1ra and IL-10, showing promise as a novel therapeutic strategy for treating allergic conjunctivitis.

FRONTIERS IN IMMUNOLOGY (2021)

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Article Medicine, General & Internal

Psoriasis

Christopher E M Griffiths et al.

LANCET (2021)

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Review Cell & Tissue Engineering

Mesenchymal stem/stromal cells as a valuable source for the treatment of immune-mediated disorders

Alexander Markov et al.

Summary: MSCs, with their various chararcteristics and ability to differentiate into multiple cell types, possess a secretome that can modulate inflammatory responses and promote tissue repair/regeneration. Their immunomodulatory effects are achieved through the harmonious interaction of released signaling molecules and immune/target cells, making them potential therapeutic candidates for immune-mediated disorders.

STEM CELL RESEARCH & THERAPY (2021)

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Article Neurosciences

Human Amniotic Epithelial Cells Alleviate a Mouse Model of Parkinson's Disease Mainly by Neuroprotective, Anti-Oxidative and Anti-Inflammatory Factors

Jiaofei Zhang et al.

Summary: The study explores the molecular mechanism by which hAECs ameliorate Parkinson's disease symptoms, including promoting the growth of damaged dopaminergic neurons and neurites through secretion of neurotrophic factors, growth factors, and anti-inflammatory factors. In addition, hAECs reduce microglial activation and neuroinflammation while decreasing excessive reactive oxygen species levels through upregulation of anti-oxidative signals.

JOURNAL OF NEUROIMMUNE PHARMACOLOGY (2021)

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Review Allergy

Mesenchymal stem cells in allergic diseases: Current status

He Li et al.

ALLERGOLOGY INTERNATIONAL (2020)

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Article Biochemistry & Molecular Biology

Decreased immunomodulatory and secretory capability of aging human umbilical cord mesenchymal stem cells in vitro

Mengbo Yang et al.

BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS (2020)

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Article Cell Biology

Proinflammatory and anti-inflammatory cytokine profiles in psoriasis: use as laboratory biomarkers and disease predictors

Camila Cataldi et al.

INFLAMMATION RESEARCH (2019)

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Article Chemistry, Multidisciplinary

Biological characterization of human amniotic epithelial cells in a serum-free system and their safety evaluation

Peng-jie Yang et al.

ACTA PHARMACOLOGICA SINICA (2018)

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Article Cell Biology

The immunomodulatory effects of adipose-derived mesenchymal stem cells and mesenchymal stem cells-conditioned medium in chronic colitis

Maryam Heidari et al.

JOURNAL OF CELLULAR PHYSIOLOGY (2018)

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Review Urology & Nephrology

Immunoregulatory mechanisms of mesenchymal stem and stromal cells in inflammatory diseases

Yufang Shi et al.

NATURE REVIEWS NEPHROLOGY (2018)

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Article Cell & Tissue Engineering

Subretinal Transplantation of Human Amniotic Epithelial Cells in the Treatment of Autoimmune Uveitis in Rats

Jinying Li et al.

CELL TRANSPLANTATION (2018)

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Article Cell & Tissue Engineering

Therapeutic effect of human amniotic epithelial cells in murine models of Hashimoto's thyroiditis and Systemic lupus erythematosus

Bing Tan et al.

CYTOTHERAPY (2018)

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Article Immunology

Discovery of the IL-23/IL-17 Signaling Pathway and the Treatment of Psoriasis

Jason E. Hawkes et al.

JOURNAL OF IMMUNOLOGY (2018)

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Article Allergy

Psoriasis pathogenesis and the development of novel targeted immune therapies

Jason E. Hawkes et al.

JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY (2017)

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Article Multidisciplinary Sciences

Mesenchymal Stem Cell-Conditioned Medium Reduces Disease Severity and Immune Responses in Inflammatory Arthritis

Alasdair G. Kay et al.

SCIENTIFIC REPORTS (2017)

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Article Biochemistry & Molecular Biology

Effects of Human Mesenchymal Stem Cells Transduced with Superoxide Dismutase on Imiquimod-Induced Psoriasis-Like Skin Inflammation in Mice

Shyam Kishor Sah et al.

ANTIOXIDANTS & REDOX SIGNALING (2016)

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Article Dermatology

The Immunopathogenesis of Psoriasis

Jaehwan Kim et al.

DERMATOLOGIC CLINICS (2015)

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Article Dermatology

Topical application of a linoleic acid-ceramide containing moisturizer exhibit therapeutic and preventive benefits for psoriasis vulgaris: a randomized controlled trial

Min Liu et al.

DERMATOLOGIC THERAPY (2015)

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Article Immunology

A novel IL-17 signaling pathway controlling keratinocyte proliferation and tumorigenesis via the TRAF4-ERK5 axis

Ling Wu et al.

JOURNAL OF EXPERIMENTAL MEDICINE (2015)

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Article Medicine, General & Internal

Psoriasis

Wolf-Henning Boehncke et al.

LANCET (2015)

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Article Rheumatology

Etiology and Pathogenesis of Psoriasis

Wolf-Henning Boehncke

RHEUMATIC DISEASE CLINICS OF NORTH AMERICA (2015)

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Article Cell & Tissue Engineering

Amniotic Membrane Mesenchymal Cells-Derived Factors Skew T Cell Polarization Toward Treg and Downregulate Th1 and Th17 Cells Subsets

Stefano Pianta et al.

STEM CELL REVIEWS AND REPORTS (2015)

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Review Biotechnology & Applied Microbiology

Prospect of Stem Cell Conditioned Medium in Regenerative Medicine

Jeanne Adiwinata Pawitan

BIOMED RESEARCH INTERNATIONAL (2014)

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Article Rheumatology

Adoptive Transfer of Human Gingiva-Derived Mesenchymal Stem Cells Ameliorates Collagen-Induced Arthritis via Suppression of Th1 and Th17 Cells and Enhancement of Regulatory T Cell Differentiation

Maogen Chen et al.

ARTHRITIS AND RHEUMATISM (2013)

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Review Dermatology

Global Epidemiology of Psoriasis: A Systematic Review of Incidence and Prevalence

Rosa Parisi et al.

JOURNAL OF INVESTIGATIVE DERMATOLOGY (2013)

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Article Dermatology

Lack of association between filaggrin gene mutations and onset of psoriasis in childhood

M. C. G. Winge et al.

JOURNAL OF THE EUROPEAN ACADEMY OF DERMATOLOGY AND VENEREOLOGY (2013)

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Article Cardiac & Cardiovascular Systems

Systemic transplantation of allogenic fetal membrane-derived mesenchymal stem cells suppresses Th1 and Th17 T cell responses in experimental autoimmune myocarditis

Makiko Ohshima et al.

JOURNAL OF MOLECULAR AND CELLULAR CARDIOLOGY (2012)

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Review Immunology

How mesenchymal stem cells interact with tissue immune responses

Yufang Shi et al.

TRENDS IN IMMUNOLOGY (2012)

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Article Biochemistry & Molecular Biology

Hornerin is a component of the epidermal cornified cell envelopes

Julie Henry et al.

FASEB JOURNAL (2011)

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Article Immunology

Pivotal Role of Dermal IL-17-Producing γδ T Cells in Skin Inflammation

Yihua Cai et al.

IMMUNITY (2011)

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Article Microbiology

Microbial Colonization Drives Expansion of IL-1 Receptor 1-Expressing and IL-17-Producing γ/δ T Cells

Jinyou Duan et al.

CELL HOST & MICROBE (2010)

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Article Immunology

TNF, but Not IL-6 and IL-17, Is Crucial for the Development of T Cell-Independent Psoriasis-Like Dermatitis in Il1rn-/- Mice

Akiko Nakajima et al.

JOURNAL OF IMMUNOLOGY (2010)

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Article Pediatrics

Transglutaminases, involucrin, and loricrin as markers of epidermal differentiation in skin substitutes derived from human sweat gland cells

Sasha Tharakan et al.

PEDIATRIC SURGERY INTERNATIONAL (2010)

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Article Cell Biology

Effects of AIN457, a Fully Human Antibody to Interleukin-17A, on Psoriasis, Rheumatoid Arthritis, and Uveitis

Wolfgang Hueber et al.

SCIENCE TRANSLATIONAL MEDICINE (2010)

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Review Immunology

IL-17 and Th17 Cells

Thomas Korn et al.

ANNUAL REVIEW OF IMMUNOLOGY (2009)

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Article Immunology

Interleukin-1 and IL-23 Induce Innate IL-17 Production from γδ T Cells, Amplifying Th17 Responses and Autoimmunity

Caroline E. Sutton et al.

IMMUNITY (2009)

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Article Biochemistry & Molecular Biology

Interplay between keratinocytes and immune cells-Recent insights into psoriasis pathogenesis

Giulia Tonel et al.

INTERNATIONAL JOURNAL OF BIOCHEMISTRY & CELL BIOLOGY (2009)

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Article Immunology

Imiquimod-Induced Psoriasis-Like Skin Inflammation in Mice Is Mediated via the IL-23/IL-17 Axis

Leslie van der Fits et al.

JOURNAL OF IMMUNOLOGY (2009)

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Article Dermatology

Highly Complex Peptide Aggregates of the S100 Fused-Type Protein Hornerin Are Present in Human Skin

Zhihong Wu et al.

JOURNAL OF INVESTIGATIVE DERMATOLOGY (2009)

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Article Multidisciplinary Sciences

Plasmacytoid dendritic cells sense self-DNA coupled with antimicrobial peptide

Roberto Lande et al.

NATURE (2007)

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Article Cell & Tissue Engineering

Stem cell characteristics of amniotic epithelial cells

T Miki et al.

STEM CELLS (2005)

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Review Medicine, General & Internal

Medical progress - Psoriasis

MP Schon et al.

NEW ENGLAND JOURNAL OF MEDICINE (2005)

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Review Biochemistry & Molecular Biology

Inhibitors of TACE and Caspase-1 as anti-inflammatory drugs

GT Le et al.

CURRENT MEDICINAL CHEMISTRY (2005)

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Article Dermatology

Psoriasis-like cutaneous inflammation in mice lacking interleukin-1 receptor antagonist

J Shepherd et al.

JOURNAL OF INVESTIGATIVE DERMATOLOGY (2004)

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Review Medicine, General & Internal

Psoriasis

M Lebwohl

LANCET (2003)

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Topical administration of the secretome derived from human amniotic epithelial cells ameliorates psoriasis-like skin lesions in mice

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