4.7 Article

Human placenta-derived mesenchymal stem cells transplantation in patients with acute respiratory distress syndrome (ARDS) caused by COVID-19 (phase I clinical trial): safety profile assessment

相关参考文献

注意:仅列出部分参考文献,下载原文获取全部文献信息。
Review Cell & Tissue Engineering

Overview of current adipose-derived stem cell (ADSCs) processing involved in therapeutic advancements: flow chart and regulation updates before and after COVID-19

Loubna Mazini et al.

Summary: Adipose-derived stem cells have low immunogenicity and various self-renewal abilities, can differentiate into different tissue-specific progenitors, migrate into damaged sites, and act through autocrine and paracrine pathways. However, the lack of standardization protocols and discrepancies in cell outcomes and engraftment pose limitations on their widespread use.

STEM CELL RESEARCH & THERAPY (2021)

Article Cell & Tissue Engineering

Umbilical cord mesenchymal stem cells for COVID-19 acute respiratory distress syndrome: A double-blind, phase 1/2a, randomized controlled trial

Giacomo Lanzoni et al.

Summary: The study confirmed safety of UC-MSC infusions in patients with COVID-19 ARDS. By reducing inflammatory cytokines, significant improvement was observed in UC-MSC-treated patients on day 6. The treatment markedly increased patient survival rate, SAE-free survival, and time to recovery.

STEM CELLS TRANSLATIONAL MEDICINE (2021)

Article Cell & Tissue Engineering

Mesenchymal stem cells derived from perinatal tissues for treatment of critically ill COVID-19-induced ARDS patients: a case series

Seyed-Mohammad Reza Hashemian et al.

Summary: This study investigated the safety and effectiveness of multiple high-dose infusions of MSCs derived from placenta and umbilical cord in critically ill COVID-19-induced ARDS patients. Some patients showed significant improvement in respiratory distress and reduction in inflammatory markers after cell infusions.

STEM CELL RESEARCH & THERAPY (2021)

Review Genetics & Heredity

The use of mesenchymal stem cells in the process of treatment and tissue regeneration after recovery in patients with Covid-19

Ehsan Saburi et al.

Summary: The emergence of the new coronavirus has raised concerns about health issues and long-term effects after patient recovery. Researchers are exploring cell-based therapy, particularly the use of MSCs, due to their immunomodulatory properties and proven therapeutic effects. Practical guidelines are needed for the use of MSCs in clinical trials.
Article Medicine, General & Internal

Compassionate mesenchymal stem cell treatment in a severe COVID-19 patient: a case report

Dragan Primorac et al.

Summary: A severe COVID-19 patient with ARDS and bacterial infection showed improvement after receiving compassionate MSC treatment, which was safe and well tolerated. Larger trials should be conducted to further study the efficacy of MSC therapy and consider its compassionate use.

CROATIAN MEDICAL JOURNAL (2021)

Review Immunology

Mesenchymal stromal/stem cells (MSCs) and MSC-derived extracellular vesicles in COVID-19-induced ARDS: Mechanisms of action, research progress, challenges, and opportunities

Susan Moradinasab et al.

Summary: The emergence of novel coronavirus in Wuhan in 2019 has caused a worldwide pandemic, leading to an unprecedented public health crisis. Mesenchymal stromal/stem cells (MSCs) have shown therapeutic potential against COVID-19 due to their immunomodulatory and anti-inflammatory effects, but challenges like malignant transformation and coagulopathy need to be addressed for successful application. Research has shown promising results in the use of MSCs for acute respiratory distress syndrome (ARDS) and viral infections, suggesting MSC therapy could be a valuable approach in treating COVID-19.

INTERNATIONAL IMMUNOPHARMACOLOGY (2021)

Review Cell & Tissue Engineering

Updates on clinical trials evaluating the regenerative potential of allogenic mesenchymal stem cells in COVID-19

Dhavan Sharma et al.

Summary: Allogenic MSC infusion is safe and effective in COVID-19 patients with ARDS, reducing inflammatory cytokines and improving patient survival and recovery time, supporting further investigation into larger clinical trials for this group of patients.

NPJ REGENERATIVE MEDICINE (2021)

Article Cell & Tissue Engineering

The Systematic Effect of Mesenchymal Stem Cell Therapy in Critical COVID-19 Patients: A Prospective Double Controlled Trial

G. Adas et al.

Summary: The aim of the clinical trial was to control cytokine storm by administering MSCs to critically ill COVID-19 patients, evaluating healing effects, and systematically investigating treatment mechanisms. The results showed positive systematic and cellular effects of MSCs application in critically ill patients, playing an important role in curing and reducing mortality.

CELL TRANSPLANTATION (2021)

Article Biochemistry & Molecular Biology

Effect of human umbilical cord-derived mesenchymal stem cells on lung damage in severe COVID-19 patients: a randomized, double-blind, placebo-controlled phase 2 trial

Lei Shi et al.

Summary: This study demonstrates that treatment with human umbilical cord-mesenchymal stem cells (UC-MSCs) can significantly improve lung lesions in COVID-19 patients and potentially have therapeutic effects in the 6-minute walk test. The incidence of adverse events was similar in both groups, indicating the good safety profile of UC-MSCs treatment.

SIGNAL TRANSDUCTION AND TARGETED THERAPY (2021)

Article Medicine, General & Internal

Clinical features of patients infected with 2019 novel coronavirus in Wuhan, China

Chaolin Huang et al.

LANCET (2020)

Article Multidisciplinary Sciences

A new coronavirus associated with human respiratory disease in China

Fan Wu et al.

NATURE (2020)

Article Critical Care Medicine

Human Umbilical Cord-Derived Mesenchymal Stem Cells for Acute Respiratory Distress Syndrome

Hon-Kan Yip et al.

CRITICAL CARE MEDICINE (2020)

Letter Medicine, General & Internal

COVID-19: Timing is Important

Giovanni de Simone et al.

EUROPEAN JOURNAL OF INTERNAL MEDICINE (2020)

Letter Medicine, General & Internal

COVID-19: consider cytokine storm syndromes and immunosuppression

Puja Mehta et al.

LANCET (2020)

Review Public, Environmental & Occupational Health

Immune response in COVID-19: A review

Mohammad Asaduzzaman Chowdhury et al.

JOURNAL OF INFECTION AND PUBLIC HEALTH (2020)

Article Multidisciplinary Sciences

COVID-19 infection: Origin, transmission, and characteristics of human coronaviruses

Muhammad Adnan Shereen et al.

JOURNAL OF ADVANCED RESEARCH (2020)

Article Cell & Tissue Engineering

Treatment of severe COVID-19 with human umbilical cord mesenchymal stem cells

Lei Shu et al.

STEM CELL RESEARCH & THERAPY (2020)

Editorial Material Cell & Tissue Engineering

Ethics of research on stem cells and regenerative medicine: ethical guidelines in the Islamic Republic of Iran

Leila Afshar et al.

STEM CELL RESEARCH & THERAPY (2020)

Article Medicine, Research & Experimental

Mesenchymal stem cell therapies for COVID-19: Current status and mechanism of action

Somaye Sadeghi et al.

LIFE SCIENCES (2020)

Article Medicine, General & Internal

Comparative evaluation of memory T cells in COVID-19 patients and predictive role of CD4+CD8+ double positive T lymphocytes as a new marker

Yasin Kalpakci et al.

REVISTA DA ASSOCIACAO MEDICA BRASILEIRA (2020)

Review Cell & Tissue Engineering

Mesenchymal Stem Cell-Based Therapy of Inflammatory Lung Diseases: Current Understanding and Future Perspectives

C. Randall Harrell et al.

STEM CELLS INTERNATIONAL (2019)

Review Oncology

Mesenchymal stem cells in idiopathic pulmonary fibrosis

Xiaohong Li et al.

ONCOTARGET (2017)

Review Cell & Tissue Engineering

Novel sources of fetal stem cells: where do they fit on the developmental continuum?

Kalliopi I. Pappa et al.

REGENERATIVE MEDICINE (2009)