The effect of desflurane, isoflurane and sevoflurane on the hemoglobin oxygen dissociation curve in human blood samples

Article Physiology

The impact of nebulized epoprostenol and iloprost on hemoglobin oxygen affinity: an ex vivo experiment

Simon Woyke et al.

Summary: Inhalational prostacyclins improve oxygenation by acting as strong vasodilators. The study found that these prostacyclins have a direct effect on hemoglobin oxygen affinity, with different effects observed in males and females, as well as females taking oral contraceptives.

AMERICAN JOURNAL OF PHYSIOLOGY-LUNG CELLULAR AND MOLECULAR PHYSIOLOGY (2022)

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Article Nutrition & Dietetics

Modulation of Hb-O-2 affinity to improve hypoxemia in COVID-19 patients

Simon Woyke et al.

Summary: This opinion paper discusses the potential impact of modulating Hb-O-2 affinity with the nutritional supplement 5-HMF on COVID-19 patients, emphasizing the critical role of oxygen affinity in hypoxemic COVID-19 patients.

CLINICAL NUTRITION (2021)

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Article Physiology

High-throughput determination of oxygen dissociation curves in a microplate reader-A novel, quantitative approach

Simon Woyke et al.

Summary: In this study, a modified 96-well plate was introduced for high throughput measurement of oxygen saturation and partial pressure in blood samples within a short time frame. The method showed precision and accuracy comparable to a standard method, and demonstrated usefulness for clinical diagnostics and basic research.

PHYSIOLOGICAL REPORTS (2021)

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Editorial Material Neurosciences