4.7 Article

Design and synthesis of new N-thioacylated ciprofloxacin derivatives as urease inhibitors with potential antibacterial activity

相关参考文献

注意:仅列出部分参考文献,下载原文获取全部文献信息。
Article Multidisciplinary Sciences

Design and synthesis of novel nitrothiazolacetamide conjugated to different thioquinazolinone derivatives as anti-urease agents

Marzieh Sohrabi et al.

Summary: The present study synthesized a series of thioquinazolinone derivatives conjugated with nitrothiazolacetamide and investigated their inhibitory activity against urease. Compound 8h exhibited the strongest inhibitory activity and showed high anti-ureolytic activity against two urease-positive microorganisms. Molecular docking study revealed that 8h interacted with multiple residues and demonstrated good hydrophobicity against urease.

SCIENTIFIC REPORTS (2022)

Article Chemistry, Physical

Novel phenylurea-pyridinium derivatives as potent urease inhibitors: Synthesis, in vitro, and in silico studies

Seyed Esmaeil Sadat-Ebrahimi et al.

Summary: In this study, novel phenylurea-pyridinium hybrids were designed, synthesized, and evaluated as urease inhibitors. The results demonstrated their superior inhibitory activity compared to standard inhibitors and their selectivity against specific pathogens.

JOURNAL OF MOLECULAR STRUCTURE (2022)

Article Chemistry, Multidisciplinary

Novel (thio)barbituric-phenoxy-N-phenylacetamide derivatives as potent urease inhibitors: synthesis,in vitrourease inhibition, andin silicoevaluations

Saeb Sedaghati et al.

Summary: A novel series of (thio)barbituric-phenoxy-N-phenylacetamide derivatives were synthesized and evaluated for their inhibitory activity against Helicobacter pylori urease, showing higher potency than standard inhibitors. Docking and molecular dynamics studies demonstrated good binding of the synthesized compounds to the urease active site, with the most potent compound creating important interactions with specific residues. In silico pharmacokinetic study predicted drug-like properties for all synthesized compounds.

STRUCTURAL CHEMISTRY (2021)

Article Multidisciplinary Sciences

Arylmethylene hydrazine derivatives containing 1,3-dimethylbarbituric moiety as novel urease inhibitors

Keyvan Pedrood et al.

Summary: In this study, a new series of arylmethylene hydrazine derivatives were synthesized and showed high anti-urease activity. Molecular modeling revealed that compounds with higher activity interacted with more residues and exhibited higher free energy, while MD investigation highlighted the importance of interaction with key residues at the urease active site in inhibiting ureolytic activity. Physico-chemical study predicted that all compounds in this series are drug-like and orally available.

SCIENTIFIC REPORTS (2021)

Article Gastroenterology & Hepatology

Demographic, Chemical, and Helicobacter pylori Positivity Assessment in Different Types of Gallstones and the Bile in a Random Sample of Cholecystectomied Iranian Patients with Cholelithiasis

Mohammad Bagher Jahantab et al.

Summary: This study aimed to investigate the characteristics of gallstone types in an Iranian population and found significant associations between stone types and factors such as age, chemical composition of stones, and H. pylori positivity. The chemical composition of stones could predict the presence of bacteria, and there was no correlation between H. pylori and gallstone formation.

CANADIAN JOURNAL OF GASTROENTEROLOGY AND HEPATOLOGY (2021)

Article Chemistry, Multidisciplinary

N-Aryl-3,4-dihydroisoquinoline Carbothioamide Analogues as Potential Urease Inhibitors

Fayaz Ali et al.

Summary: N-Aryl-3,4-dihydroisoquinoline carbothioamide analogues 1-22 were synthesized and shown to have urease inhibitory potential, with some compounds more potent than the standard thiourea. Compounds with electron-donating groups demonstrated superior activity in inhibiting urease.

ACS OMEGA (2021)

Article Chemistry, Multidisciplinary

Pantoprazole Derivatives: Synthesis, Urease Inhibition Assay and In Silico Molecular Modeling Studies

Homa Azizian et al.

CHEMISTRYSELECT (2020)

Article Biochemistry & Molecular Biology

Novel thiobarbiturates as potent urease inhibitors with potential antibacterial activity: Design, synthesis, radiolabeling and biodistribution study

Hanan Gaber Abdulwahab et al.

BIOORGANIC & MEDICINAL CHEMISTRY (2020)

Article Chemistry, Multidisciplinary

New ciprofloxacin-dithiocarbamate-benzyl hybrids: design, synthesis, antibacterial evaluation, and molecular modeling studies

Ensieh Nasli Esfahani et al.

RESEARCH ON CHEMICAL INTERMEDIATES (2019)

Article Chemistry, Multidisciplinary

The Structure of the Elusive Urease-Urea Complex Unveils the Mechanism of a Paradigmatic Nickel-Dependent Enzyme

Luca Mazzei et al.

ANGEWANDTE CHEMIE-INTERNATIONAL EDITION (2019)

Review Chemistry, Medicinal

Antibacterial activity study of 1,2,4-triazole derivatives

Feng Gao et al.

EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY (2019)

Article Multidisciplinary Sciences

Intrinsic enzymatic properties modulate the self-propulsion of micromotors

Xavier Arque et al.

NATURE COMMUNICATIONS (2019)

Article Biochemistry & Molecular Biology

Design, synthesis and antibacterial activity evaluation of moxifloxacin-amide-1,2,3-triazole-isatin hybrids

Feng Gao et al.

BIOORGANIC CHEMISTRY (2019)

Review Chemistry, Medicinal

Ciprofloxacin derivatives and their antibacterial activities

Gui-Fu Zhang et al.

EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY (2018)

Review Chemistry, Medicinal

4-Quinolone derivatives and their activities against Gram positive pathogens

Gui-Fu Zhang et al.

EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY (2018)

Review Chemistry, Medicinal

Recent advances of imidazole-containing derivatives as anti tubercular agents

Yi-Lei Fan et al.

EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY (2018)

Article Chemistry, Medicinal

Design, synthesis and antimicrobial evaluation of propylene-tethered ciprofloxacin-isatin hybrids

Ruo Wang et al.

EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY (2018)

Review Chemistry, Medicinal

Quinolone derivatives and their activities against methicillin-resistant Staphylococcus aureus (MRSA)

Chuan Gao et al.

EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY (2018)

Review Chemistry, Medicinal

Recent developments of quinolone-based derivatives and their activities against Escherichia coli

Feng Gao et al.

EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY (2018)

Review Public, Environmental & Occupational Health

Antimicrobial resistance: a global multifaceted phenomenon

Francesca Prestinaci et al.

PATHOGENS AND GLOBAL HEALTH (2015)

Review Multidisciplinary Sciences

An overview on the potential of natural products as ureases inhibitors: A review

Luzia V. Modolo et al.

JOURNAL OF ADVANCED RESEARCH (2015)

Review Biochemistry & Molecular Biology

Development of Quorum-Based Anti-Virulence Therapeutics Targeting Gram-Negative Bacterial Pathogens

Song Buck Tay et al.

INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES (2013)

Review Chemistry, Medicinal

Urease inhibitors as potential drugs for gastric and urinary tract infections: a patent review

Paulina Kosikowska et al.

EXPERT OPINION ON THERAPEUTIC PATENTS (2011)

Editorial Material Biochemistry & Molecular Biology

Thioamides in Nature: In Search of Secondary Metabolites in Anaerobic Microorganisms

Srinivas Banala et al.

CHEMBIOCHEM (2010)

Article Chemistry, Multidisciplinary

Synthesis, antibacterial and antifungal activities of 3-aryl-5-(pyridin-3-y1)-4,5-dihydropyrazole-1-carbothioamide derivatives

M. Shekarchi et al.

JOURNAL OF THE IRANIAN CHEMICAL SOCIETY (2008)

Review Chemistry, Multidisciplinary

Thiopeptide antibiotics

MC Bagley et al.

CHEMICAL REVIEWS (2005)