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Article
Multidisciplinary Sciences
Dinesh Aggarwal et al.
Summary: Understanding the transmission of SARS-CoV-2 in higher education settings is crucial in limiting spread among students and at-risk populations. A study conducted at the University of Cambridge analyzed viral isolates and found limited introductions of the virus into the university. Student cases were primarily linked to a single genetic cluster, likely originating from social gatherings outside of the university. Transmission was observed within student accommodations and courses but was effectively contained through local infection control measures and a national lockdown. The study highlights important factors in SARS-CoV-2 transmission and effective interventions in higher education settings.
NATURE COMMUNICATIONS
(2022)
Review
Infectious Diseases
Dinesh Aggarwal et al.
Summary: This study reviewed all genomic epidemiology studies on COVID-19 in long-term care facilities (LTCFs) and found that staff and residents usually had identical or very similar SARS-CoV-2 genomes. Outbreaks typically involved one main cluster, and the same lineages persisted despite infection control measures. It was also observed that the sequencing technique was reliable over time, and when combined with local epidemiology, genomics could help identify probable transmission sources. Multiple studies detected transmission between LTCFs, and the mortality rate among residents was high regardless of the lineage.
Article
Infectious Diseases
Michela Antonelli et al.
Summary: Despite the high efficacy of COVID-19 vaccines, some individuals still become infected with SARS-CoV-2 post-vaccination. Risk factors for post-vaccination infection include frailty in older adults, living in deprived areas, and obesity. Vaccination is associated with reduced odds of severe symptoms and long-duration illness. The findings suggest the importance of targeting at-risk populations and maintaining infection control measures even in vaccinated individuals.
LANCET INFECTIOUS DISEASES
(2022)
Article
Biochemistry & Molecular Biology
Emma C. Thomson et al.
Summary: SARS-CoV-2 virus can mutate and evade immunity, with mutations like N439K conferring resistance against neutralizing monoclonal antibodies and enhancing binding affinity to hACE2 receptor. Despite similar in vitro replication fitness and clinical outcomes compared to wild type, N439K mutation highlights the importance of ongoing molecular surveillance for guiding vaccine and therapeutic development and usage.
Article
Biochemistry & Molecular Biology
Ivica Letunic et al.
Summary: The Interactive Tree Of Life is an online tool for displaying, manipulating, and annotating phylogenetic and other trees. The latest version 5 introduces a new tree display engine and several new features, such as a new dataset type and expanded annotation options. Users can now also manually annotate trees by hand, providing more flexibility and control.
NUCLEIC ACIDS RESEARCH
(2021)
Article
Infectious Diseases
Kimberly Marsh et al.
Summary: Based on Scottish national contact tracing data, Public Health Scotland estimated that the EURO 2020 significantly contributed to a third wave of COVID-19 infections, with the majority of cases being males aged 20-39 who attended unofficial gatherings rather than official matches. Targeted guidance on celebrating safely in closed spaces is crucial in preventing further spread.
Review
Microbiology
William T. Harvey et al.
Summary: The evolution of SARS-CoV-2 has been characterized by the emergence of mutations and variants that impact virus characteristics. Manufacturers are preparing for possible updates to vaccines in response to changes in the virus population, and it is crucial to monitor genetic and antigenic changes alongside experiments to understand the impacts of mutations.
NATURE REVIEWS MICROBIOLOGY
(2021)
Article
Infectious Diseases
Edward M. Hill et al.
Summary: The study found that with full adherence to isolation and test and trace measures, the infection rate among students during the autumn term was 22%, compared to 69% without adherence. Students living on-campus had a higher infection rate on average than those living off-campus. Regular mass testing, along with strict adherence to isolation and test and trace measures, could greatly reduce the proportion of infected students during the term.
Article
Multidisciplinary Sciences
Jessica Enright et al.
Summary: The study found that university outbreaks in late 2020 were consistent with infections brought by arriving students. In terms of control measures, student adherence to testing and self-isolation was deemed more important than staggering the return of students to reduce transmission. In the context of a more transmissible variant, frequent testing would be necessary to prevent a major outbreak.
ROYAL SOCIETY OPEN SCIENCE
(2021)
Article
Biochemistry & Molecular Biology
Bui Quang Minh et al.
MOLECULAR BIOLOGY AND EVOLUTION
(2020)
Article
Medicine, General & Internal
Qun Li et al.
NEW ENGLAND JOURNAL OF MEDICINE
(2020)
Article
Biochemistry & Molecular Biology
Xi He et al.
Article
Microbiology
Andrew Rambaut et al.
NATURE MICROBIOLOGY
(2020)
Article
Infectious Diseases
Luke W. Meredith et al.
LANCET INFECTIOUS DISEASES
(2020)
Article
Biochemistry & Molecular Biology
Dillon C. Adam et al.
Editorial Material
Medicine, General & Internal
Gavin Yamey et al.
BMJ-BRITISH MEDICAL JOURNAL
(2020)
Article
Public, Environmental & Occupational Health
A. L. Donaldson et al.
EPIDEMIOLOGY AND INFECTION
(2020)
Article
Biochemical Research Methods
Subha Kalyaanamoorthy et al.
Article
Biochemistry & Molecular Biology
Jaime Huerta-Cepas et al.
MOLECULAR BIOLOGY AND EVOLUTION
(2016)
