Prevalence and outcome of anemia among children hospitalized for pneumonia and their risk of mortality in a developing country

Data are limited on the prevalence and outcome of anemia and its risk on mortality among children under five years of age hospitalized for pneumonia/severe pneumonia. Thus, we conducted a secondary analysis of data extracted from Dhaka Hospital of International Centre for Diarrhoeal Disease Research, Bangladesh to address the evidence gap. Among 3468 children fulfilling the study criteria,1712 (49.4%) had anemia. If children aged <= 1.0, > 1.0 to 2.0, > 2.0 to < 6.0, and >= 6.0 to 59 months had blood hemoglobin (Hb) value of <= 10.7 g/dL, <= 9.4 g/dL, <= 9.5 g/dL, and <= 11 g/dl respectively; we considered them anemic. The trend of prevalence of anemia was found to be inversely related to increasing age (Chi-square for linear trend analysis was done to understand the relation of anemia with increasing age, which was = 6.96; p = 0.008). During hospitalization anemic children more often developed respiratory failure (7.2% vs. 4.4%, p < 0.001) and fatal outcome (7.1.0% vs. 4.2%, p < 0.001) than the children who did not have anemia. After adjusting for potential confounders, such as female sex, lack of immunization, abnormal mental status, severe acute malnutrition, dehydration, hypoxemia, severe sepsis, and bacteremia using multivariable logistic regression analysis, anemia was found to be independently associated with fatal outcome (OR = 1.88, 95% CI 1.23-2.89, p = 0.004). Thus, future interventional studies on the early management of anemia may be warranted to understand whether the intervention reduces the morbidity and deaths in such children.

Automated summary

This study analyzed data extracted from the Dhaka Hospital of International Centre for Diarrhoeal Disease Research in Bangladesh to investigate the prevalence and outcome of anemia among children under five years of age hospitalized for pneumonia/severe pneumonia. The study found that anemia was inversely related to increasing age and was independently associated with respiratory failure and fatal outcome during hospitalization. Interventional studies on the early management of anemia may be necessary to reduce morbidity and mortality in these children.