4.7 Article

A polygenic score indexing a DRD2-related co-expression network is associated with striatal dopamine function

相关参考文献

注意:仅列出部分参考文献,下载原文获取全部文献信息。
Article Biochemistry & Molecular Biology

Striatal dopaminergic alterations in individuals with copy number variants at the 22q11.2 genetic locus and their implications for psychosis risk: a [18F]-DOPA PET study

Maria Rogdaki et al.

Summary: Dopaminergic dysfunction is associated with genetic risk for psychosis, particularly in individuals with 22q11.2 deletion. This study found increased striatal dopamine synthesis capacity in individuals with 22q11.2 deletion compared to healthy controls and individuals with 22q11.2 duplication. Furthermore, dopamine synthesis was positively correlated with the severity of psychosis-risk symptoms.

MOLECULAR PSYCHIATRY (2023)

Article Genetics & Heredity

Calculating Polygenic Risk Scores (PRS) in UK Biobank: A Practical Guide for Epidemiologists

Jennifer A. Collister et al.

Summary: Polygenic risk scores estimate the genetic risk of an individual for a disease or trait by aggregating the effects of common genetic variants associated with the condition. The increasing availability of genetic data has made the inclusion of this genetic risk in statistical analyses more widespread, but guidance on the simple calculation and application of existing genetic scores is lacking. By discussing specific tools and techniques, this guide aims to make polygenic risk scores more accessible to researchers.

FRONTIERS IN GENETICS (2022)

Article Neurosciences

Prefrontal and Striatal Dopamine Release Are Inversely Correlated in Schizophrenia

W. Gordon Frankle et al.

Summary: This study found deficits of dopamine release in cortical brain regions of schizophrenia patients, and an inverse relationship between dopamine release in the striatal brain region and cortical brain region, which supports the current dopamine hypothesis of schizophrenia.

BIOLOGICAL PSYCHIATRY (2022)

Article Multidisciplinary Sciences

Mapping genomic loci implicates genes and synaptic biology in schizophrenia

Vassily Trubetskoy et al.

Summary: In this study, a two-stage genome-wide association study was conducted to identify common variants associated with schizophrenia. The results revealed 287 distinct genomic loci and 120 genes likely to be involved in the development of schizophrenia. This research provides valuable insights into the pathophysiology of schizophrenia and offers a resource for further mechanistic studies.

NATURE (2022)

Article Neurosciences

A potential biomarker for treatment stratification in psychosis: evaluation of an [18F] FDOPA PET imaging approach

Mattia Veronese et al.

Summary: The study evaluated the potential of [F-18]FDOPA PET imaging to identify non-responders to antipsychotic treatment using linear and non-linear machine learning analyses and found good test-retest reproducibility and predictive power in distinguishing responders from non-responders. The economic analysis indicated potential healthcare cost savings by using [F-18]FDOPA PET to fast-track treatment-resistant patients to clozapine. Overall, the findings suggest that [F-18]FDOPA PET dopamine imaging has the potential to serve as a biomarker to guide treatment choice for patients with schizophrenia.

NEUROPSYCHOPHARMACOLOGY (2021)

Review Biochemistry & Molecular Biology

11C- and 18F-Radiotracers for In Vivo Imaging of the Dopamine System: Past, Present and Future

Michael R. Kilbourn

Summary: The application of positron emission tomography (PET) imaging to study brain biochemistry, especially dopamine neurotransmission, has significantly grown over the past 40 years. PET imaging of dopaminergic functions in the central nervous system is routinely used for research in neurology, psychiatry, drug abuse and addiction, as well as drug development. The key advancement in PET imaging is the development of unique radiotracers labeled with positron-emitting radionuclides like carbon-11 and fluorine-18, which have greatly contributed to the progress in this field.

BIOMEDICINES (2021)

Article Neurosciences

Coexpression network architecture reveals the brain-wide and multiregional basis of disease susceptibility

Christopher L. Hartl et al.

Summary: By leveraging RNA sequencing data, researchers were able to identify brain-wide, cross-regional, and region-specific coexpression modules. Genetic risk for schizophrenia and autism was enriched in brain-wide and multiregional modules, indicating broad impact.

NATURE NEUROSCIENCE (2021)

Article Multidisciplinary Sciences

Brain network dynamics during working memory are modulated by dopamine and diminished in schizophrenia

Urs Braun et al.

Summary: Working memory performance involves brain-wide switching between activity states, with stability of states related to dopamine D1 receptor gene expression and state transitions influenced by D2 receptor expression. Individuals with schizophrenia show altered network control properties in working memory, indicating the relevance of dopamine signaling in whole-brain network dynamics and its link to schizophrenia pathophysiology.

NATURE COMMUNICATIONS (2021)

Review Psychiatry

Schizophrenia-An Overview

Robert A. McCutcheon et al.

JAMA PSYCHIATRY (2020)

Article Psychiatry

Dopamine and glutamate in schizophrenia: biology, symptoms and treatment

Robert A. McCutcheon et al.

WORLD PSYCHIATRY (2020)

Article Biochemistry & Molecular Biology

Determinants of treatment response in first-episode psychosis: an 18F-DOPA PET study

Sameer Jauhar et al.

MOLECULAR PSYCHIATRY (2019)

Article Biochemical Research Methods

Genetic association testing using the GENESIS R/Bioconductor package

Stephanie M. Gogarten et al.

BIOINFORMATICS (2019)

Article Biochemistry & Molecular Biology

Association of genetic ancestry with striatal dopamine D2/D3 receptor availability

C. E. Wiers et al.

MOLECULAR PSYCHIATRY (2018)

Article Biochemistry & Molecular Biology

Genomic Dissection of Bipolar Disorder and Schizophrenia, Including 28 Subphenotypes

Douglas M. Ruderfer et al.

Article Biochemistry & Molecular Biology

The effect of the DISC1 Ser704Cys polymorphism on striatal dopamine synthesis capacity: an [F-18]-DOPA PET study

Tarik Dahoun et al.

HUMAN MOLECULAR GENETICS (2018)

Article Multidisciplinary Sciences

Transcriptomic context of DRD1 is associated with prefrontal activity and behavior during working memory

Leonardo Fazio et al.

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2018)

Article Psychiatry

The integrated landscape of causal genes and pathways in schizophrenia

Changguo Ma et al.

TRANSLATIONAL PSYCHIATRY (2018)

Article Multidisciplinary Sciences

Dopaminergic basis for signaling belief updates, but not surprise, and the link to paranoia

Matthew M. Nour et al.

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2018)

Article Multidisciplinary Sciences

Transcriptome-wide isoform-level dysregulation in ASD, schizophrenia, and bipolar disorder

Michael J. Gandal et al.

SCIENCE (2018)

Article Biochemical Research Methods

Gene co-expression analysis for functional classification and gene-disease predictions

Sipko van Dam et al.

BRIEFINGS IN BIOINFORMATICS (2018)

Article Psychiatry

Antipsychotic plasma levels in the assessment of poor treatment response in schizophrenia

R. McCutcheon et al.

ACTA PSYCHIATRICA SCANDINAVICA (2018)

Article Biochemistry & Molecular Biology

Open chromatin profiling of human postmortem brain infers functional roles for non-coding schizophrenia loci

John F. Fullard et al.

HUMAN MOLECULAR GENETICS (2017)

Review Behavioral Sciences

The DRD2 rs1076560 polymorphism and schizophrenia-related intermediate phenotypes: A systematic review and meta-analysis

Jurjen J. Luykx et al.

NEUROSCIENCE AND BIOBEHAVIORAL REVIEWS (2017)

Article Psychiatry

SA83. Brain Glutamate Levels and Antipsychotic Response in Schizophrenia

Alice Egerton et al.

SCHIZOPHRENIA BULLETIN (2017)

Review Biochemistry & Molecular Biology

An Expanded View of Complex Traits: From Polygenic to Omnigenic

Evan A. Boyle et al.

Article Genetics & Heredity

Cognitive Analysis of Schizophrenia Risk Genes That Function as Epigenetic Regulators of Gene Expression

Laura Whitton et al.

AMERICAN JOURNAL OF MEDICAL GENETICS PART B-NEUROPSYCHIATRIC GENETICS (2016)

Article Neurosciences

Gene expression elucidates functional impact of polygenic risk for schizophrenia

Menachem Fromer et al.

NATURE NEUROSCIENCE (2016)

Review Genetics & Heredity

Systems biology and gene networks in neurodevelopmental and neurodegenerative disorders

Neelroop N. Parikshak et al.

NATURE REVIEWS GENETICS (2015)

Article Neurosciences

Dopaminergic Function in Cannabis Users and Its Relationship to Cannabis-Induced Psychotic Symptoms

Michael A. P. Bloomfield et al.

BIOLOGICAL PSYCHIATRY (2014)

Article Multidisciplinary Sciences

Biological insights from 108 schizophrenia-associated genetic loci

Stephan Ripke et al.

NATURE (2014)

Article Multidisciplinary Sciences

DRD2/CHRNA5 Interaction on Prefrontal Biology and Physiology during Working Memory

Annabella Di Giorgio et al.

PLOS ONE (2014)

Article Neurosciences

The link between dopamine function and apathy in cannabis users: an [18F]-DOPA PET imaging study

Michael A. P. Bloomfield et al.

PSYCHOPHARMACOLOGY (2014)

Article Psychiatry

Dopamine Synthesis Capacity in Patients With Treatment-Resistant Schizophrenia

Arsime Demjaha et al.

AMERICAN JOURNAL OF PSYCHIATRY (2012)

Review Psychiatry

The Nature of Dopamine Dysfunction in Schizophrenia and What This Means for Treatment

Oliver D. Howes et al.

ARCHIVES OF GENERAL PSYCHIATRY (2012)

Article Neurosciences

Increased Stress-Induced Dopamine Release in Psychosis

Romina Mizrahi et al.

BIOLOGICAL PSYCHIATRY (2012)

Letter Biochemistry & Molecular Biology

Progressive increase in striatal dopamine synthesis capacity as patients develop psychosis: a PET study

O. Howes et al.

MOLECULAR PSYCHIATRY (2011)

Article Multidisciplinary Sciences

Temporal dynamics and genetic control of transcription in the human prefrontal cortex

Carlo Colantuoni et al.

NATURE (2011)

Review Pharmacology & Pharmacy

The Physiology, Signaling, and Pharmacology of Dopamine Receptors

Jean-Martin Beaulieu et al.

PHARMACOLOGICAL REVIEWS (2011)

Article Biochemical Research Methods

Data quality control in genetic case-control association studies

Carl A. Anderson et al.

NATURE PROTOCOLS (2010)

Article Geriatrics & Gerontology

Age-dependent decline of steady state dopamine storage capacity of human brain: An FDOPA PET study

Yoshitaka Kumakura et al.

NEUROBIOLOGY OF AGING (2010)

Article Psychiatry

Elevated Striatal Dopamine Function Linked to Prodromal Signs of Schizophrenia

Oliver D. Howes et al.

ARCHIVES OF GENERAL PSYCHIATRY (2009)

Article Neurosciences

Striatal Dopamine and Working Memory

Susan M. Landau et al.

CEREBRAL CORTEX (2009)

Review Neurosciences

Relationship of Striatal Dopamine Synthesis Capacity to Age and Cognition

Meredith N. Braskie et al.

JOURNAL OF NEUROSCIENCE (2008)

Article Neurosciences

Working memory capacity predicts dopamine synthesis capacity in the human striatum

Roshan Cools et al.

JOURNAL OF NEUROSCIENCE (2008)

Article Biochemistry & Molecular Biology

COXPRESdb: a database of coexpressed gene networks in mammals

Takeshi Obayashi et al.

NUCLEIC ACIDS RESEARCH (2008)

Article Biochemistry & Molecular Biology

A general framework for weighted gene co-expression network analysis

Bin Zhang et al.

STATISTICAL APPLICATIONS IN GENETICS AND MOLECULAR BIOLOGY (2005)

Review Neurosciences

Mesolimbic dopaminergic pathways in fear conditioning

MA Pezze et al.

PROGRESS IN NEUROBIOLOGY (2004)

Review Neurosciences

Impulse activity of midbrain dopamine neurons modulates drug-seeking behavior

M Marinelli et al.

PSYCHOPHARMACOLOGY (2003)

Article Multidisciplinary Sciences

Dopamine controls the firing pattern of dopamine neurons via a network feedback mechanism

CA Paladini et al.

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2003)

Article Multidisciplinary Sciences

Genomics and behavior - Toward behavioral genomics

P McGuffin et al.

SCIENCE (2001)