4.7 Article

Brain fractalkine-CX3CR1 signalling is anti-obesity system as anorexigenic and anti-inflammatory actions in diet-induced obese mice

相关参考文献

注意:仅列出部分参考文献,下载原文获取全部文献信息。
Article Endocrinology & Metabolism

Impaired brain fractalkine-CX3CR1 signaling is implicated in cognitive dysfunction in diet-induced obese mice

Namiko Kawamura et al.

Summary: The study showed that DIO mice exhibited significant cognitive deficits in the Y-maze test and decrease in fractalkine and CX3CR1 in the hippocampus and amygdala compared with mice fed a control diet. Administration of the CX3CR1 antagonist 18a in normal mice induced significant cognitive deficits in the Y-maze test.

BMJ OPEN DIABETES RESEARCH & CARE (2021)

Article Endocrinology & Metabolism

CX3CL1-CX3CR1 Signaling Deficiency Exacerbates Obesity-induced Inflammation and Insulin Resistance in Male Mice

Mayumi Nagashimada et al.

Summary: The CX3CL1-CX3CR1 system is crucial in regulating inflammation, particularly in obese mice with adipose tissue inflammation and insulin resistance. Deficiency in CX3CR1 signaling leads to an increase in M1 polarized macrophages, worsening glucose tolerance and insulin resistance in obese mice. Targeting the CX3CL1-CX3CR1 system may be beneficial in treating type 2 diabetes by modulating M1/M2 macrophages.

ENDOCRINOLOGY (2021)

Article Endocrinology & Metabolism

CX3CL1-CX3CR1 Signaling Deficiency Exacerbates Obesity-induced Inflammation and Insulin Resistance in Male Mice

Mayumi Nagashimada et al.

Summary: The CX3CL1-CX3CR1 system regulates inflammation in obese mice by affecting adipose tissue macrophage recruitment and polarization, leading to insulin resistance. Deficiency in CX3CR1 signaling results in a dominant shift towards M1-polarized macrophages, exacerbating insulin resistance in obese mice. Therapies targeting CX3CL1-CX3CR1 system may be beneficial for treating type 2 diabetes by modulating M1/M2 macrophages.

ENDOCRINOLOGY (2021)

Article Neurosciences

Fractalkine Modulates Microglia Metabolism in Brain Ischemia

Clotilde Lauro et al.

FRONTIERS IN CELLULAR NEUROSCIENCE (2019)

Article Clinical Neurology

Surgical Trauma Exacerbates Cognitive Deficits and Neuroinflammation in Aged Rats: The Role of CX3CL1-CX3CR1 Signaling

Zhe Li et al.

JOURNAL OF NEUROPATHOLOGY AND EXPERIMENTAL NEUROLOGY (2018)

Article Multidisciplinary Sciences

Regulation of energy rheostasis by the melanocortin-3 receptor

Masoud Ghamari-Langroudi et al.

SCIENCE ADVANCES (2018)

Article Multidisciplinary Sciences

Sex differences in microglial CX3CR1 signalling determine obesity susceptibility in mice

Mauricio D. Dorfman et al.

NATURE COMMUNICATIONS (2017)

Review Neurosciences

Melanocortin-4 receptor-regulated energy homeostasis

Michael J. Krashes et al.

NATURE NEUROSCIENCE (2016)

Article Multidisciplinary Sciences

Metabolic Effects of CX3CR1 Deficiency in Diet-Induced Obese Mice

Rachana Shah et al.

PLOS ONE (2015)

Article Neurosciences

CX3CL1 is up-regulated in the rat hippocampus during memory-associated synaptic plasticity

Graham K. Sheridan et al.

FRONTIERS IN CELLULAR NEUROSCIENCE (2014)

Article Biochemistry & Molecular Biology

The Fractalkine/CX3CR1 System Regulates β Cell Function and Insulin Secretion

Yun Sok Lee et al.

Article Endocrinology & Metabolism

Hypothalamic Inflammation: Marker or Mechanism of Obesity Pathogenesis?

Joshua P. Thaler et al.

DIABETES (2013)

Review Neurosciences

Current status of chemokines in the adult CNS

Annabelle Reaux-Le Goazigo et al.

PROGRESS IN NEUROBIOLOGY (2013)

Review Multidisciplinary Sciences

Central nervous system control of metabolism

Martin G. Myers et al.

NATURE (2012)

Article Endocrinology & Metabolism

Impaired CNS Leptin Action Is Implicated in Depression Associated with Obesity

Nobuko Yamada et al.

ENDOCRINOLOGY (2011)

Article Biochemistry & Molecular Biology

Activation of Adenosine A2A Receptor Up-Regulates BDNF Expression in Rat Primary Cortical Neurons

Se Jin Jeon et al.

NEUROCHEMICAL RESEARCH (2011)

Article Neurosciences

Microglial Cx3cr1 knockout prevents neuron loss in a mouse model of Alzheimer's disease

Martin Fuhrmann et al.

NATURE NEUROSCIENCE (2010)

Article Neurosciences

Regulation of Tau Pathology by the Microglial Fractalkine Receptor

Kiran Bhaskar et al.

NEURON (2010)

Article Endocrinology & Metabolism

Hypothalamic proinflammatory lipid accumulation, inflammation, and insulin resistance in rats fed a high-fat diet

Kelly A. Posey et al.

AMERICAN JOURNAL OF PHYSIOLOGY-ENDOCRINOLOGY AND METABOLISM (2009)

Article Biochemistry & Molecular Biology

Hypothalamic IKKβ/NF-κB and ER stress link overnutrition to energy imbalance and obesity

Xiaoqing Zhang et al.

Review Cardiac & Cardiovascular Systems

Neuroendocrine control of food intake

Elena Valassi et al.

NUTRITION METABOLISM AND CARDIOVASCULAR DISEASES (2008)

Article Physiology

Brain-derived neurotrophic factor in the hypothalamic paraventricular nucleus reduces energy intake

ChuanFeng Wang et al.

AMERICAN JOURNAL OF PHYSIOLOGY-REGULATORY INTEGRATIVE AND COMPARATIVE PHYSIOLOGY (2007)

Article Neurosciences

Control of microglial neurotoxicity by the fractalkine receptor

Astrid E. Cardona et al.

NATURE NEUROSCIENCE (2006)

Article Biochemistry & Molecular Biology

Inhibitory effects of U73122 and U73343 on Ca2+ influx and pore formation induced by the activation of P2X7 nucleotide receptors in mouse microglial cell

T Takenouchi et al.

BIOCHIMICA ET BIOPHYSICA ACTA-GENERAL SUBJECTS (2005)

Article Endocrinology & Metabolism

Selective impairment of insulin signalling in the hypothalamus of obese Zucker rats

JBC Carvalheira et al.

DIABETOLOGIA (2003)

Article Neurosciences

Fractalkine protein localization and gene expression in mouse brain

G Tarozzo et al.

JOURNAL OF NEUROSCIENCE RESEARCH (2003)

Review Biotechnology & Applied Microbiology

Obesity therapy: Altering the energy intake-and- expenditure balance sheet

VEE Crowley et al.

NATURE REVIEWS DRUG DISCOVERY (2002)

Article Biochemistry & Molecular Biology

BDNF regulates eating behavior and locomotor activity in mice

SG Kernie et al.

EMBO JOURNAL (2000)

Article Endocrinology & Metabolism

Intermittent administration of brain-derived neurotrophic factor ameliorates glucose metabolism in obese diabetic mice

M Ono et al.

METABOLISM-CLINICAL AND EXPERIMENTAL (2000)