期刊
NUTRIENTS
卷 14, 期 13, 页码 -出版社
MDPI
DOI: 10.3390/nu14132568
关键词
major depressive disorder; anxiety; mental disorders; ultra-processed food; NOVA; meta-analysis; nutritional psychiatry; psychiatry
资金
- Fernwood Foundation
- Wilson Foundation
- A2 Milk Company
- Be Fit Foods
- Deakin University Scholarship
- Deakin University
- Bega Dairy and Drinks Pty Ltd.
- NHMRC Emerging Leader 2 Fellowship [2009295]
- NHMRC Synergy Grant [APP1182301]
- National Health & Medical Research Council
- Australian Research Council
- University of Melbourne
- Sanofi
- Meat and Livestock Australia
- Woolworths Limited
- Brain and Behaviour Research Institute
- National Health and Medical Research Council (NHMRC)
- Australian Rotary Health
- Geelong Medical Research Foundation
- Ian Potter Foundation
- Eli Lilly
- NHMRC Investigator Grant [2008971]
- Multiple Sclerosis Research Australia early-career fellowship
- Cobram Estate Pty. Ltd.
- Nutrition Society of Australia
- Nutrition Research Australia
- ParachuteBH
This study aimed to investigate the association between the consumption of ultra-processed food and mental disorders through a synthesis and meta-analysis of previous research. The findings suggest that greater consumption of ultra-processed food is associated with increased odds of depressive and anxiety symptoms, as well as an increased risk of subsequent depression.
Since previous meta-analyses, which were limited only to depression and by a small number of studies available for inclusion at the time of publication, several additional studies have been published assessing the link between ultra-processed food consumption and depression as well as other mental disorders. We aimed to build on previously conducted reviews to synthesise and meta-analyse the contemporary evidence base and clarify the associations between the consumption of ultra-processed food and mental disorders. A total of 17 observational studies were included (n = 385,541); 15 cross-sectional and 2 prospective. Greater ultra-processed food consumption was cross-sectionally associated with increased odds of depressive and anxiety symptoms, both when these outcomes were assessed together (common mental disorder symptoms odds ratio: 1.53, 95%CI 1.43 to 1.63) as well as separately (depressive symptoms odds ratio: 1.44, 95%CI 1.14 to 1.82; and, anxiety symptoms odds ratio: 1.48, 95%CI 1.37 to 1.59). Furthermore, a meta-analysis of prospective studies demonstrated that greater ultra-processed food intake was associated with increased risk of subsequent depression (hazard ratio: 1.22, 95%CI 1.16 to 1.28). While we found evidence for associations between ultra-processed food consumption and adverse mental health, further rigorously designed prospective and experimental studies are needed to better understand causal pathways.
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