期刊
NUTRIENTS
卷 14, 期 12, 页码 -出版社
MDPI
DOI: 10.3390/nu14122504
关键词
Phaeodactylum tricornutum; eicosapentaenoic acid; fucoxanthin; beta-glucan; chrysolaminarin
资金
- Ministry for Science, Research and Art within the Bioeconomy research Program of Baden-Wurttemberg [BOBW2-105A, FKZ-7533-10-5-185B]
Microalgae such as Phaeodactylum tricornutum can be used as a sustainable and nutritious source, providing benefits such as increased body weight gain and improved composition of gut microbiota and short-chain fatty acids.
Microalgae such as Phaeodactylum tricornutum (PT) are a sustainable source of nutrients, especially eicosapentaenoic acid (EPA), fucoxanthin (Fx), and chrysolaminarin (Chrl), the concentrations of which can vary depending on the culture conditions. We generated three types of diets containing either an EPA- and Fx-rich (EPA/Fx) or Chrl-rich microalgae (with 5, 15, or 25% added to the diet) or an isocaloric control diet (CD). These diets were evaluated over 14 days in young C57BL/6J mice for safety and bioavailability, short-chain fatty acid (SCFA) production, and microbiome analysis. Both microalgae diets increased body weight gain dose-dependently compared to the CD. Microalgae-derived EPA was well absorbed, resulting in increased liver and fat tissue levels and a decrease in the n-6:n-3 ratio in liver tissue. Both microalgae diets increased the production of selected SCFA and decreased the Firmicutes/Bacteriodota ratio, whereas the Chrl-rich diet led to an increase in Akkermansia. Doses of up to 4621 mg Chrl, 920 mg EPA, and 231 mg Fx per kg body weight daily were tolerated without adverse effects. This pre-clinical study shows that PT is suitable for mouse feed, with positive effects on microbiota composition and SCFA production, suggesting beneficial effects on gut health.
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