4.7 Article

Effect of a Dietary Supplement Combining Bioactive Peptides and Magnesium on Adjustment Disorder with Anxiety: A Clinical Trial in General Practice

期刊

NUTRIENTS
卷 14, 期 12, 页码 -

出版社

MDPI
DOI: 10.3390/nu14122425

关键词

anxiety; stress; bioactive peptide; magnesium; dietary supplement

资金

  1. Normandy Region [17P03672]

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Anxiety is a common psychological disorder that is often treated with benzodiazepines. However, these drugs have side effects and can lead to dependence. In this study, a dietary supplement was evaluated as an alternative treatment for anxiety, and it was found to be effective in reducing symptoms with minimal side effects.
Anxiety is a high frequency disorder in the general population. It is usually treated with benzodiazepines, which cause side effects and a dependence that could make withdrawal difficult. Alternative treatments are therefore needed to reduce the use of anxiolytics, particularly for adjustment disorder with anxiety. An observational, multicentre, prospective, longitudinal study has been conducted by general practitioners and one gynaecologist to evaluate the efficacy of a dietary supplement on adjustment disorder with anxiety (Stress 2 study). Patients diagnosed as anxious with a score of >= 20 on the Hamilton Anxiety Rating Scale (Ham-A, first visit on Day 0 (V0)) were offered a 28-day treatment with a dietary supplement formulated with bioactive peptides from a fish protein hydrolysate (Gabolysat (R)), magnesium and vitamin B6. At the second visit (V1), the Ham-A Rating Scale, the Patient Global Impression scale (PGI) and the Clinical Global Impressions scale (CGI) were administered. A 50% reduction in the Ham-A score, was achieved for 41.9% of the patients. The mean Ham-A score decreased by 12.1 +/- 5.7 points (p < 0.001) between V0 (25.6 +/- 3.8) and V1 (13.6 +/- 6.0). Furthermore, according to the CGI scale, the anxiety of 75.3% of patients improved significantly and very significantly, with limited side effects and a negligible rebound effect. In conclusion, adjustment disorder with anxiety seems to be effectively managed by an alternative and safer solution than benzodiazepines.

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