期刊
NUTRIENTS
卷 14, 期 15, 页码 -出版社
MDPI
DOI: 10.3390/nu14153025
关键词
adaptation; behavior; phase shift; sepsis; time-restricted feeding
资金
- National Natural Science Foundation of China [32171165, 31871190]
- National Key R&D Program of China [2019YFA0802400]
Time-restricted feeding (TRF) has been shown to alleviate circadian disruption, especially in the case of jet lag in mice, with beneficial effects in certain situations.
Nowadays, more and more people are suffering from circadian disruption. However, there is no well-accepted treatment. Recently, time-restricted feeding (TRF) was proposed as a potential non-drug intervention to alleviate jet lag in mice, especially in mice treated with a 6-h advanced phase shift. Here, we challenged C57BL/6 mice with a 6-h delay phase shift or a 12-h shift (day-night reversal) combined with 6- or 12-h TRF within the dark phase and found the beneficial effects of given TRF strategies in certain phase-shifting situations. Although behavioral fitness did not correlate well with health status, none of the TRF strategies we used deteriorated lipopolysaccharide-induced sepsis. These findings improve our understanding of the benefits of TRF for adaptation to circadian disruption.
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