期刊
NEUROSCIENCE BULLETIN
卷 38, 期 11, 页码 1292-1302出版社
SPRINGER
DOI: 10.1007/s12264-022-00891-0
关键词
Auditory cortex; Auditory behavior; BPA exposure; Cortical processing; Plasticity
资金
- National Natural Science Foundation of China [32171134, 32161160325]
- Project of Shanghai Science and Technology Commission [21490713200]
- Program of Introducing Talents of Discipline to Universities [B16018]
- NYU-ECNU Institute of Brain and Cognitive Science at NYU Shanghai
- National Science and Technology Innovation 2030 Major Program [2022ZD0204804]
Exposure to BPA during development affects auditory cortical processing and auditory discrimination, particularly in the temporal domain.
Developmental exposure to bisphenol A (BPA), an endocrine-disrupting contaminant, impairs cognitive function in both animals and humans. However, whether BPA affects the development of primary sensory systems, which are the first to mature in the cortex, remains largely unclear. Using the rat as a model, we aimed to record the physiological and structural changes in the primary auditory cortex (A1) following lactational BPA exposure and their possible effects on behavioral outcomes. We found that BPA-exposed rats showed significant behavioral impairments when performing a sound temporal rate discrimination test. A significant alteration in spectral and temporal processing was also recorded in their A1, manifested as degraded frequency selectivity and diminished stimulus rate-following by neurons. These post-exposure effects were accompanied by changes in the density and maturity of dendritic spines in A1. Our findings demonstrated developmental impacts of BPA on auditory cortical processing and auditory-related discrimination, particularly in the temporal domain. Thus, the health implications for humans associated with early exposure to endocrine disruptors such as BPA merit more careful examination.
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