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Drug Delivery Systems with a Tumor-Triggered Targeting or Intracellular Drug Release Property Based on DePEGylation

MATERIALS (2022)

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Quantifying the heterogeneity of enzymatic dePEGylation of liposomal nanocarrier systems

Rasmus Eliasen et al.

Summary: Lipid nanoparticles have shown clinical success in vaccines, but better tools are needed to analyze heterogeneities at the single particle level. Here, we present a fluorescence microscopy based assay to detect enzyme mediated dePEGylation of individual liposomes, and investigate the factors affecting this process.

EUROPEAN JOURNAL OF PHARMACEUTICS AND BIOPHARMACEUTICS (2022)

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Promoted cellular uptake and intracellular cargo release of ICG/DOX-carrying hybrid polymeric nanoassemblies upon acidity-activated PEG detachment to enhance cancer photothermal/chemo combination therapy

Yu-Ning Hung et al.

Summary: The PEGylation of nanoparticles in drug delivery systems can enhance drug solubility and circulation time, but uptake by cancer cells may be hindered. This study developed hybrid polymeric nanoassemblies for co-delivery of ICG and DOX, showing promise for cancer treatment through improved anti-cancer efficacy. Further research is needed to investigate their performance in different environments.

EUROPEAN POLYMER JOURNAL (2022)

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Article Pharmacology & Pharmacy

Shell-Sheddable Micelles Based on Poly(ethylene glycol)-hydrazone-poly[R,S]-3-hydroxybutyrate Copolymer Loaded with 8-Hydroxyquinoline Glycoconjugates as a Dual Tumor-Targeting Drug Delivery System

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Summary: The study evaluates the effectiveness of pH-sensitive nanocarriers and glycoconjugation of drugs in improving the selectivity of anticancer therapy.

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Article Engineering, Biomedical

A cascade synergetic strategy induced by photothermal effect based on platelet exosome nanoparticles for tumor therapy

Yuying Ma et al.

Summary: This study developed a laser-controlled nanosystem (FG@PEL) by combining platelet exosomes and photothermal sensitive liposomes, with glucose oxidase (GOx) and ferric ammonium (FAC) incorporated. The nanosystem exhibited cascade targeting and therapeutic strategies, utilizing the biological properties of platelet exosomes and the photothermal effect to enhance tumor targeting and chemodynamic therapy (CDT). The synergistic effect of FG@PEL, achieved through the accelerated reaction rate by photothermal effect, showed significant therapeutic efficacy, providing a promising strategy for curative tumor therapy.

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Cellulose-Based Nanomaterials Advance Biomedicine: A Review

Hani Nasser Abdelhamid et al.

Summary: This article reviews the applications of cellulose in the field of biomedicine, including antibacterial agents, antifouling, wound healing, drug delivery, tissue engineering, and bone regeneration. Cellulose-based materials possess customizable chemical, mechanical, and physical properties, making them suitable for biomedical applications.

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Enzyme-responsive smart nanocarriers for targeted chemotherapy: an overview

Hiral Kapalatiya et al.

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Complement activation induced by PEG enhances humoral immune responses against antigens encapsulated in PEG-modified liposomes

Taro Shimizu et al.

Summary: In this study, we developed a delivery system using hydroxy PEG-modified liposomes (HO-PEG-Lip) that efficiently activated the complement system, facilitated the association with MZ-B cells, and significantly enhanced antigen delivery in vivo. The manipulation of HO-PEG density at 2 mol% in total lipids led to a successful induction of OVA-specific IgG response after a single intravenous injection. This new delivery technique may provide a simple and effective way to deliver antigens to MZ-B cells, inducing a significant humoral immune response.

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Enzymatically Transformable Polymersome-Based Nanotherapeutics to Eliminate Minimal Relapsable Cancer

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Yichen Li et al.

Summary: Red blood cells have been utilized as biocompatible carriers for delivering bioactive substances for many years, with some drug-loaded RBC formulations reaching clinical trials for treating tumors and neurological diseases. Advanced delivery strategies have been proposed by combining RBCs with other novel systems to further exploit and expand the application of RBCs.

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pH-sensitive and tumor-targeting nanogels based on ortho ester-modified PEG for improving the in vivo anti-tumor efficiency of doxorubicin

Xin Wang et al.

Summary: By copolymerizing various components, a pH-sensitive and tumor-targeting nanogel was developed, showing a spherical structure and excellent stability. In vitro and in vivo experiments demonstrated good drug delivery and antitumor effects of the multifunctional nanogels.

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Shirin Mollazadeh et al.

Summary: Redox-responsive drug delivery nanoplatforms address the challenges in conventional drug delivery and enable targeted delivery, widely used in designing nanoparticles. By cleaving diselenide and disulfide bonds, controlled loading, delivery, and release of poorly water-soluble anticancer drugs at tumor site can be achieved.

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Yafei Li et al.

Summary: The study presents a strategy for delivering drug nanoparticles into cells with nucleus-targeting ability under visible light irradiation. These drug nanoparticles have high drug loading capacity and specific nucleus-targeting ability, efficiently killing cancer cells. This self-assembly strategy can be applied to other hydrophobic drugs and targeting ligands for photo-controlled organelle-targeted drug delivery.

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Michael J. Mitchell et al.

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Ying Kuang et al.

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Jiaxi Xu et al.

Summary: A sequentially responsive nanogel was fabricated to enhance the efficacy of platinum(II) chemotherapy, leading to superior inhibition rate in A549/DDP tumor by targeting sialic acid residues and depleting intracellular glutathione. The nanogel demonstrated stealth property in blood circulation and increased stability in vivo through chemical crosslinking, highlighting its potential as an effective strategy for cancer treatment.

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Xiangyu Xu et al.

Summary: This article introduces a novel dual-sensitive anticancer drug delivery system that can enhance cancer cell uptake and endocytosis capability through surface charge reversal in the tumor microenvironment. The system utilizes a series of steps involving nanoparticle encapsulation, redox-sensitive disulfide bond for drug release, and rapid charge reversal for better uptake, demonstrating sensitivity to both reducing and weakly acidic environments.

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Global cancer statistics 2020: GLOBOCAN estimates of incidence and mortality worldwide for 36 cancers in 185 countries

Hyuna Sung et al.

Summary: The global cancer burden in 2020 saw an estimated 19.3 million new cancer cases and almost 10.0 million cancer deaths. Female breast cancer surpassed lung cancer as the most commonly diagnosed cancer, while lung cancer remained the leading cause of cancer death. These trends are expected to rise in 2040, with transitioning countries experiencing a larger increase compared to transitioned countries due to demographic changes and risk factors associated with globalization and a growing economy. Efforts to improve cancer prevention measures and provision of cancer care in transitioning countries will be crucial for global cancer control.

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Leonard Ionut Atanase

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Quoc-Viet Le et al.

Summary: Cell membrane-derived vesicles, with their unique multicomponent feature, have the potential to overcome various obstacles encountered in vivo and have created a new category of drug delivery systems. This technology has significant potential applications in the field of drug delivery.

ACTA PHARMACEUTICA SINICA B (2021)

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Jiayue Shi et al.

Summary: This paper outlines the recent progress of poly(ethylene glycol) (PEG)-based biodegradable thermosensitive hydrogels in the biomedical field, emphasizing their potential applications in drug release and cell growth. Thermosensitive hydrogels with designed and regulated properties exhibit excellent biocompatibility and degradability, providing a demonstration for the design of new thermogelling systems.

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Multi-stimuli responsive hollow MnO2-based drug delivery system for magnetic resonance imaging and combined chemo-chemodynamic cancer therapy

Xiangyu Xu et al.

Summary: The research focuses on the exploration and application of hollow manganese dioxide nanoparticles (HMDN) for biosensing and biomedicine, particularly in tumor-targeted drug delivery. The prepared DOX@HMDN-PEI-PLL(cit) nanoparticles have shown promising results in vitro and in vivo studies, demonstrating their potential as a drug delivery system for targeted cancer therapy. The nanoparticles exhibit a stealthy property under physiological conditions and enhanced therapeutic effects with minimal side effects, showcasing their potential for future applications in cancer treatment.

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Dynamic precise dual-drug-backboned nano-prodrugs for selective chemotherapy

Longshun Yang et al.

Summary: The PEGylated dual-drug backboned nano-prodrugs were successfully constructed with defined structure, precise drug ratio, extraordinary high drug loading, and reduction/pH dual sensitivity. These nano-prodrugs exhibited stable storage and blood circulation through PEGylation and low critical micelle concentration, enhanced tumor accumulation and cellular uptake via extracellular DePEGylation and dynamic size translation, and synergetic cytotoxicity via intracellular efficient drug release. This study may pave the way for easy industrial manufacture, quality control, and highly selective chemotherapy for clinical translation.

ACTA BIOMATERIALIA (2021)

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Dynamic methotrexate nano-prodrugs with detachable PEGylation for highly selective synergistic chemotherapy

Xiaodong Lv et al.

Summary: The pH-ultra-sensitive dynamic methotrexate nanoprodrugs with detachable PEGylation were prepared successfully for highly selective synergistic chemotherapy. The nano-prodrugs demonstrated stability, efficient drug release, and enhanced tumor accumulation under different pH conditions.

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Lili Ren et al.

Summary: The simple and functional modification of nanoparticle surfaces is used for efficient delivery of chemotherapeutic drugs for cancer treatment. Constructing a nanocrystalline drug delivery system with doxorubicin wrapped in red blood cell membranes shows superior properties compared to traditional free drug treatments, providing a promising foundation for further development and clinical trials of anti-cancer drug nanocarriers in the future.

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Review Nanoscience & Nanotechnology

Recent Advances in Macrophage-Mediated Drug Delivery Systems

Tiantian Liang et al.

Summary: Macrophages play a crucial role in drug delivery systems, prolonging drug circulation and release, enhancing stability and targeting ability. However, further research and optimization are needed for their potential applications.

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Design of a Platelet-Mediated Delivery System for Drug-Incorporated Nanospheres to Enhance Anti-Tumor Therapeutic Effect

Jun-ichiro Jo et al.

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Review Pharmacology & Pharmacy

Combination of Nanomaterials in Cell-Based Drug Delivery Systems for Cancer Treatment

Lu Tang et al.

Summary: Cell-based drug delivery systems offer significant advantages in cancer treatment by utilizing different cell types for specific tumor targeting and enhancing the circulation time of nanoparticles. Nanomaterials play a crucial role in enhancing the properties of cell-based drug delivery systems for cancer therapy.

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Hydrogen Bond Strength-Mediated Self-Assembly of Supramolecular Nanogels for Selective and Effective Cancer Treatment

Fasih Bintang Ilhami et al.

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A chitosan/mesoporous silica nanoparticle-based anticancer drug delivery system with a tumor-triggered targeting property

Tao Liao et al.

Summary: In this study, a dual-pH-sensitive chitosan/mesoporous silica nanoparticle-based anticancer drug delivery system was developed using the tumor-triggered targeting strategy. Both in vitro and in vivo studies demonstrated that the system could induce cancer cell apoptosis, inhibit tumor growth, and reduce the cytotoxicity of the drug against normal cells, showing potential for cancer therapy.

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NIR light-responsive nanocarriers for controlled release

Yiyuan Tang et al.

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Dual-stimuli responsive near-infrared emissive carbon dots/hollow mesoporous silica-based integrated theranostics platform for real-time visualized drug delivery

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Inge Katrin Herrmann et al.

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NATURE NANOTECHNOLOGY (2021)

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PEG-Polymer Encapsulated Aggregation-Induced Emission Nanoparticles for Tumor Theranostics

Jun Dai et al.

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Tumor Microenvironment-Responsive Shell/Core Composite Nanoparticles for Enhanced Stability and Antitumor Efficiency Based on a pH-Triggered Charge-Reversal Mechanism

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Star-Shape Redox-Responsive PEG-Sheddable Copolymer of Disulfide-Linked Polyethylene Glycol-Lysine-di-Tocopherol Succinate for Tumor-Triggering Intracellular Doxorubicin Rapid Release: Head-to-Head Comparison

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The structure of PEG-modified poly(ethylene imines) influences biodistribution and pharmacokinetics of their complexes with NF-κB decoy in mice

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