期刊
MATERIALS
卷 15, 期 15, 页码 -出版社
MDPI
DOI: 10.3390/ma15155240
关键词
metal oxide coatings; magnetron sputtering; osteogenesis; mesenchymal stem cells
类别
资金
- Comision de Operacion y Fomento de Actividades Academicas (COFAA-IPN)
- Estimulo al Desempeno Docente-IPN grants
- SIP-IPN grants [20211631, 20221624]
- program Posgrado de Doctorado en Ciencias en Biomedicina y Biotecnologia Molecular, Escuela Nacional de Ciencias Biologicas at the Instituto Politecnico Nacional
- CONACyT [CVU 739515]
- [CONACyT-CB-288101]
- [CONACYT-Frontera-1740]
- [DGAPA-PAPIIT-IN101419]
Biomaterials with adequate properties are crucial for orthopedic and dental implants. Metal oxide coatings, such as TiO2, ZrO2, Nb2O5, and Ta2O5, have shown promise but lack comparative studies. In this study, thin films of these coatings were deposited and characterized. Cell adhesion, viability, proliferation, and differentiation experiments revealed that all coatings were biocompatible, with Nb2O5 and Ta2O5 showing better cell proliferation and longer differentiation time.
Biomaterials with adequate properties to direct a biological response are essential for orthopedic and dental implants. The surface properties are responsible for the biological response; thus, coatings with biologically relevant properties such as osteoinduction are exciting options to tailor the surface of different bulk materials. Metal oxide coatings such as TiO2, ZrO2, Nb2O5 and Ta2O5 have been suggested as promising for orthopedic and dental implants. However, a comparative study among them is still missing to select the most promising for bone-growth-related applications. In this work, using magnetron sputtering, TiO2, ZrO2, Ta2O5, and Nb2O5 thin films were deposited on Si (100) substrates. The coatings were characterized by Optical Profilometry, Scanning Electron Microscopy, Energy-Dispersive X-ray Spectroscopy, X-ray Photoelectron Spectroscopy, X-ray Diffraction, Water Contact Angle measurements, and Surface Free Energy calculations. The cell adhesion, viability, proliferation, and differentiation toward the osteoblastic phenotype of mesenchymal stem cells plated on the coatings were measured to define the biological response. Results confirmed that all coatings were biocompatible. However, a more significant number of cells and proliferative cells were observed on Nb2O5 and Ta2O5 compared to TiO2 and ZrO2. Nevertheless, Nb2O5 and Ta2O5 seemed to induce cell differentiation toward the osteoblastic phenotype in a longer cell culture time than TiO2 and ZrO2.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据